{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:31:49Z","timestamp":1770222709158,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3626,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006928","name":"Ohio State University Veterinary Scholar Summer Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension and albuminuria often coexist in Greyhounds, suggesting generalized vascular dysfunction that could contribute to the development of a variety of diseases in this breed. Eicosanoid metabolites of arachidonic acid (AA) mediate endothelial function, vascular reactivity, and proteinuria in humans and in rodent models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>The eicosanoid profile of Greyhounds is shifted toward metabolites that promote vascular dysfunction, hypertension, and proteinuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Healthy Greyhounds (n = 20) and non-Greyhound (n = 20) dogs that were consecutively enrolled in a blood donor program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Plasma eicosanoid metabolites were assayed by liquid chromatography\/electrospray ionization mass spectrometry (LC\/ESI\/MS) and compared to systolic blood pressure (SP) measurements and urine albumin concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Isomers of hydroxyeicosatetraenoic acid (HETE) were higher in Greyhounds than non-Greyhounds (median, range in pmol\/mL: 5(S)HETE 19.82, 8.55\u201332.95 versus 13.54, 4.33\u201326.27, P = .033; 8(S)HETE 9.39, 3.28\u201319.84 versus 5.80, 2.25\u201317.66, P = .002; 9(S)HETE 9.46, 2.43\u201313.79 versus 5.82, 1.50\u201317.16, P = .026; 12(S)HETE 10.17, 3.81\u201340.06 versus 7.24, 2.9\u201316.16, P = .022). Dihydroxyeicosatrienoic acid (DHET) isomers also were higher in Greyhounds compared to non-Greyhounds (mean \u00b1 SD in pmol\/mL: 8,9DHET 5.78 \u00b1 2.13 versus 4.03 \u00b1 1.36, P = .004; 11,12DHET 11.98 \u00b1 2.86 versus 8.90 \u00b1 3.48, P = .004; 14,15DHET 7.23 \u00b1 2.19 versus 5.76 \u00b1 1.87, P = .028). Albuminuria correlated with total DHET (rs = 0.46, P = .003). SP was positively correlated with 11,12EET (rs = 0.42, P = .006) and 20(S)HETE (rs = 0.38, P = .017). SP and 8,9EET were inversely correlated (rs = \u22120.49, P = .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Plasma eicosanoid profile in Greyhounds was consistent with activation of metabolic pathways known to promote vascular dysfunction and might contribute to higher blood pressures and albuminuria. Inhibition of these eicosanoid pathways should be evaluated as therapeutic targets in Greyhounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.13833","type":"journal-article","created":{"date-parts":[[2016,1,24]],"date-time":"2016-01-24T23:46:46Z","timestamp":1453679206000},"page":"583-590","source":"Crossref","is-referenced-by-count":10,"title":["Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non-Greyhound Dogs"],"prefix":"10.1093","volume":"30","author":[{"given":"J.T.","family":"Martinez","sequence":"first","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Biosciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.K.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kellogg","sequence":"additional","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Iazbik","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Couto","sequence":"additional","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Pressler","sequence":"additional","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Hoepf","sequence":"additional","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Biosciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Radin","sequence":"additional","affiliation":[{"name":"Ohio State University College of Veterinary Medicine Department of Veterinary Biosciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"2026020304511635400_jvim13833-bib-0001","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1939-1676.2008.0088.x","article-title":"Postoperative bleeding in retired racing Greyhounds","volume":"22","author":"Lara-Garcia","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020304511635400_jvim13833-bib-0002","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2460\/javma.245.1.113","article-title":"Ischemic stroke in Greyhounds: 21 cases (2007\u20132013)","volume":"245","author":"Kent","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"2026020304511635400_jvim13833-bib-0003","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/030098589503200501","article-title":"Glomerular ultrastructural lesion of idiopathic cutaneous and renal glomerular vasculopathy of Greyhounds","volume":"32","author":"Hertzke","year":"1995","journal-title":"Vet Pathol"},{"key":"2026020304511635400_jvim13833-bib-0004","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1939-1676.2007.tb01945.x","article-title":"Results of a web-based health survey of retired racing Greyhounds","volume":"21","author":"Lord","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026020304511635400_jvim13833-bib-0005","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/j.1939-1676.2012.01008.x","article-title":"Arterial blood pressure, proteinuria, and renal histopathology in clinically healthy retired racing Greyhounds","volume":"26","author":"Surman","year":"2012","journal-title":"J Vet Intern Med"},{"key":"2026020304511635400_jvim13833-bib-0006","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/CS20060247","article-title":"Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions","volume":"112","author":"Savoia","year":"2007","journal-title":"Clin Sci"},{"key":"2026020304511635400_jvim13833-bib-0007","first-page":"13","article-title":"Proteinuria and its relation to cardiovascular disease","volume":"7","author":"Currie","year":"2013","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"2026020304511635400_jvim13833-bib-0008","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1524-6175.2007.06445.x","article-title":"Microalbuminuria: what is it? 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