{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:23:59Z","timestamp":1770218639944,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3626,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#MOF102751"],"award-info":[{"award-number":["#MOF102751"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Foundation for Innovation","award":["#29172"],"award-info":[{"award-number":["#29172"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heaves is a severe debilitating condition of horses, characterized by lower airway inflammation and permanent structural changes of the bronchial wall. Chronic inflammation promotes the formation of new vessels, a phenomenon known as angiogenesis. Narrow band imaging (NBI) endoscopy is a noninvasive technique that enhances the visualization of submucosal vessels, and commonly is employed for the study of angiogenesis in human patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Using NBI, we aimed to determine whether or not the central airways of horses with heaves undergo angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Horses with heaves during exacerbation of the disease (n = 5) and healthy controls (n = 6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A library of NBI images was established from previously recorded videoendoscopies. Images were acquired by an operator blinded to horse ID. Images were obtained from 3 sites: 130 from the trachea (14 \u00b1 9.3 [mean \u00b1 SD] images per horse with heaves and 10 \u00b1 5.4 from controls; P = .45), 58 from the carina (5.4 \u00b1 3.2 from horses with heaves and 5.2 \u00b1 2.8 fromn controls; P &amp;gt; .99) and 167 from the intermediate bronchi (17.8 \u00b1 6.7 from horses with heaves and 13 \u00b1 5.6 from controls; P = .17). Using dedicated stereology software (NewCAST, Visiopharm; Denmark), the volume density of superficial and deep vessels was calculated blindly by point counting at each site for all horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the trachea, the volume density of superficial vessels was increased in horses with heaves compared to controls (P = .02). No difference was found between groups for the volume density of both superficial and deep vessels at the carina or intermediate bronchi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Relevance<\/jats:title>\n                    <jats:p>NBI imaging of the airways was easily performed in standing sedated horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.13890","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T09:41:30Z","timestamp":1456825290000},"page":"671-674","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic Evaluation of Angiogenesis in the Large Airways of Horses with Heaves Using Narrow Band Imaging"],"prefix":"10.1093","volume":"30","author":[{"given":"N.","family":"Herteman","sequence":"first","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bullone","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"Lavoie","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"2026020304510382900_jvim13890-bib-0001","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1440-1843.2011.02033.x","article-title":"Heaves, an asthma-like 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