{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:50:46Z","timestamp":1791697846032,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3565,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Doberman Pinschers with dilated cardiomyopathy (DCM) are at high risk of sudden cardiac death (SCD). Risk factors for SCD are poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess cardiac biomarkers, Holter-ECG, echocardiographic variables and canine characteristics in a group of Doberman Pinschers with DCM dying of SCD and in a DCM control group to identify factors predicting SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Animals<\/jats:title>\n                    <jats:p>A longitudinal prospective study was performed in 95 Doberman Pinschers with DCM. Forty-one dogs died within 3\u00a0months after the last cardiac examination (SCD-group) and were compared to 54 Doberman Pinschers with DCM surviving 1\u00a0year after inclusion. Holter-ECG, echocardiography, measurement of N-terminal prohormone of brain-natriuretic peptide (NT-proBNP), and cardiac Troponin I (cTnI) concentrations were recorded for all dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Volume overload of the left ventricle (left ventricular end-diastolic volume (LVEDV\/BSA)\u00a0&amp;gt;\u00a091.3\u00a0mL\/m\u00b2) was the single best variable to predict SCD. The probability of SCD increases 8.5-fold (CI0.95\u00a0=\u00a00.8\u201335.3) for every 50\u00a0mL\/m\u00b2-unit increment in LVEDV\/BSA. Ejection fraction (EF), left ventricular end-systolic volume (LVESV\/BSA) and NT-proBNP were highly correlated with LVEDV\/BSA (r\u00a0=\u00a0\u22120.63, 0.96, 0.86, respectively). Generated conditional inference trees (CTREEs) revealed that the presence of ventricular tachycardia (VT), increased concentration of cTnI, and the fastest rate (FR) of ventricular premature complexes (VPC) \u2265260\u00a0beats per minute (bpm) are additional important variables to predict SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Conditional inference trees provided in this study might be useful for risk assessment of SCD in Doberman Pinschers with DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.13941","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T02:58:43Z","timestamp":1463194723000},"page":"722-732","source":"Crossref","is-referenced-by-count":35,"title":["Predictors of Sudden Cardiac Death in Doberman Pinschers with Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"30","author":[{"given":"L.","family":"Kl\u00fcser","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Holler","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Simak","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tater","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Smets","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"R\u00fcgamer","sequence":"additional","affiliation":[{"name":"Statistical Consulting Unit, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"K\u00fcchenhoff","sequence":"additional","affiliation":[{"name":"Statistical Consulting Unit, LMU University , Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wess","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, LMU University , 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