{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:19:36Z","timestamp":1789690776235,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":3416,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Remodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Airway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fourteen healthy horses and 24 horses with heaves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 14-point scoring system assessing central bronchial wall inflammation and remodeling was developed. The score was validated by 2 pathologists using specimens obtained from 18 horses (6 controls, 6 with heaves exacerbation, and 6 with heaves remission) in which lung function had been assessed with impulse oscillometry. Clinical and research application of the score was evaluated using biopsy specimens obtained from 20 additional horses (8 controls, 6 with heaves exacerbation, and 6 with heaves remission).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The score was repeatable (interclass correlation coefficient = 69%). It differentiated horses with heaves in exacerbation (mean \u00b1 SD: 6.2 \u00b1 2.2) from those in remission (4.0 \u00b1 1.0) and controls (3.6 \u00b1 1.7, P &amp;lt; 0.0001). The histological scores of horses with heaves correlated with the ratio of respiratory resistance (R) at 5 and 10 Hz (R5 : R10 ratio, r = 0.65, P = 0.03), a parameter assessing airway obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Significance<\/jats:title>\n                    <jats:p>The proposed histological scoring system correlates with the degree of airway obstruction measured by impulse oscillometry. However, it does not discriminate horses with heaves in remission from controls. Evaluation of EBB specimens might be considered in future research and clinical studies of respiratory diseases in horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14556","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T03:35:21Z","timestamp":1471318521000},"page":"1739-1746","source":"Crossref","is-referenced-by-count":22,"title":["Development of a Semiquantitative Histological Score for the Diagnosis of Heaves Using Endobronchial Biopsy Specimens in Horses"],"prefix":"10.1093","volume":"30","author":[{"given":"M.","family":"Bullone","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al Department of Clinical Sciences, , St-Hyacinthe, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"H\u00e9lie","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Universit\u00e9 de Montr\u00e9al Department of Pathology and Microbiology, , St-Hyacinthe, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Joubert","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval , Quebec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-P.","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al Department of Clinical Sciences, , St-Hyacinthe, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2026020303121992900_jvim14556-bib-0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2746\/042516401776767412","article-title":"International Workshop on Equine Chronic Airway Disease. 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