{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:35:41Z","timestamp":1789770941542,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":3416,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Aratana Therapeutics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thin body condition and weight loss are common in cats with chronic kidney disease (CKD). However, the time course and progression of weight loss before and after diagnosis have not been thoroughly evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To describe weight loss in cats with CKD before and after diagnosis and its relationship to survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 569 cats (55.5% females and 44.5% males) with CKD from 6 US veterinary practices for which International Renal Interest Society (IRIS) stage, age, date of CKD diagnosis, and at least two body weight measurements were available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Body weight measurements were analyzed by time windows and polynomial growth curve analysis. Survival analysis was performed by Kaplan\u2013Meier curves and log-rank tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age at diagnosis was 14.9 years (range, 5.0\u201322.8 years). Cats were categorized at diagnosis as IRIS stage 1 (n = 34 [6%]), stage 2 (n = 345 [61%]), stage 3 (n = 141 [25%]), and stage 4 (n = 49 [9%]). Median body weight at diagnosis was 4.2 kg (range, 1.6\u20139.9 kg). Cats lost a median of 8.9% of body weight in the 12 months before diagnosis, but weight loss was already present 3 years before diagnosis and accelerated after diagnosis of CKD. Cats &amp;lt;4.2 kg at the time of diagnosis had significantly shorter survival time compared to cats \u2265 4.2 kg at diagnosis (P &amp;lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Weight loss can be detected in cats before diagnosis of CKD, accelerates after diagnosis, and is associated with shorter survival. Tracking body weight may help clinicians in earlier diagnosis of CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14561","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T03:36:27Z","timestamp":1471318587000},"page":"1661-1666","source":"Crossref","is-referenced-by-count":76,"title":["Evaluation of Weight Loss Over Time in Cats with Chronic Kidney Disease"],"prefix":"10.1093","volume":"30","author":[{"given":"L.M.","family":"Freeman","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University , North Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-P.","family":"Lachaud","sequence":"additional","affiliation":[{"name":"Aratana Therapeutics, Inc. , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Aratana Therapeutics, Inc. , Kansas City, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zollers","sequence":"additional","affiliation":[{"name":"Aratana Therapeutics, Inc. , Kansas City, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2026020303120548100_jvim14561-bib-0001","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2460\/javma.1987.190.09.1196","article-title":"Clinicopathologic findings associated with chronic renal disease in cats: 74 cases (1973\u20131984)","volume":"190","author":"DiBartola","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303120548100_jvim14561-bib-0002","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1748-5827.1998.tb03598.x","article-title":"Feline chronic renal failure: Clinical findings in 80 cases diagnosed between 1992 and 1995","volume":"39","author":"Elliott","year":"1998","journal-title":"J Small Anim Pract"},{"key":"2026020303120548100_jvim14561-bib-0003","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2460\/ajvr.1999.60.01.109","article-title":"Plasma amino acid profiles in cats with naturally acquired chronic renal failure","volume":"60","author":"Goldstein","year":"1999","journal-title":"Am J Vet Res"},{"key":"2026020303120548100_jvim14561-bib-0004","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1939-1676.2008.0163.x","article-title":"Survival in cats with naturally occurring chronic kidney disease (2000\u20132002)","volume":"22","author":"Boyd","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2460\/javma.244.3.320","article-title":"Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals","volume":"244","author":"Greene","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303120548100_jvim14561-bib-0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1939-1676.2011.00838.x","article-title":"Cachexia and sarcopenia: Emerging syndromes of importance in dogs and cats","volume":"26","author":"Freeman","year":"2012","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0007","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1939-1676.2007.tb03042.x","article-title":"Prognostic factors in cats with chronic kidney disease","volume":"21","author":"King","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0008","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/1098612X14563097","article-title":"Survey of dietary and medication practices of owners of cats with chronic kidney disease","volume":"17","author":"Markovich","year":"2015","journal-title":"J Feline Med Surg"},{"key":"2026020303120548100_jvim14561-bib-0009","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1053\/j.ajkd.2007.02.277","article-title":"Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis","volume":"49","author":"Kovesdy","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"2026020303120548100_jvim14561-bib-0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pharmthera.2008.09.009","article-title":"Cardiac cachexia: A systematic overview","volume":"121","author":"von Haehling","year":"2009","journal-title":"Pharmacol Ther"},{"key":"2026020303120548100_jvim14561-bib-0011","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2460\/javma.1999.214.08.1201","article-title":"Factors contributing to the decision for euthanasia of dogs with congestive heart failure","volume":"214","author":"Mallery","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303120548100_jvim14561-bib-0012","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1939-1676.2010.0584.x","article-title":"The relationship between body weight, body condition, and survival in cats with heart failure","volume":"24","author":"Finn","year":"2010","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0013","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1939-1676.2008.0071.x","article-title":"Association of body weight and body condition with survival in dogs with heart failure","volume":"22","author":"Slupe","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0014","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jfms.2007.02.005","article-title":"A prospective investigation of the prevalence and prognostic significance of weight loss and changes in body condition in feline cancer patients","volume":"9","author":"Baez","year":"2007","journal-title":"J Feline Med Surg"},{"key":"2026020303120548100_jvim14561-bib-0015","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/j.1939-1676.2011.00805.x","article-title":"Association between body condition and survival in dogs with acquired chronic kidney disease","volume":"25","author":"Parker","year":"2011","journal-title":"J Vet Intern Med"},{"key":"2026020303120548100_jvim14561-bib-0016","article-title":"Design and Analysis of Quality of Life Studies in Clinical Trials","author":"Fairclough","year":"2010","edition":"2"},{"key":"2026020303120548100_jvim14561-bib-0017","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat Med"},{"key":"2026020303120548100_jvim14561-bib-0018","doi-asserted-by":"crossref","first-page":"991","DOI":"10.4065\/mcp.2010.0336","article-title":"The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis","volume":"85","author":"Kalantar-Zadeh","year":"2010","journal-title":"Mayo Clinic Proc"},{"key":"2026020303120548100_jvim14561-bib-0019","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ahj.2009.10.026","article-title":"Obesity and survival in patients with heart failure and preserved systolic function: A U-shaped relationship","volume":"159","author":"Kapoor","year":"2010","journal-title":"Am Heart J"},{"key":"2026020303120548100_jvim14561-bib-0020","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.athoracsur.2008.05.044","article-title":"Body mass index and outcome after ventricular assist device placement","volume":"86","author":"Musci","year":"2008","journal-title":"Ann Thoracic Surg"},{"key":"2026020303120548100_jvim14561-bib-0021","first-page":"251","article-title":"Applied Veterinary Clinical Nutrition","author":"Elliott","year":"2012"},{"key":"2026020303120548100_jvim14561-bib-0022","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5326\/0460285","article-title":"AAHA nutritional assessment guidelines for dogs and cats","volume":"46","author":"Baldwin","year":"2010","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303120548100_jvim14561-bib-0023","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1748-5827.2011.01079.x","article-title":"WSAVA nutritional assessment guidelines","volume":"52","author":"Freeman","year":"2011","journal-title":"J Small Anim Pract"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.14561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.14561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.14561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/30\/5\/1661\/66307126\/jvim14561.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/30\/5\/1661\/66307126\/jvim14561.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:12:19Z","timestamp":1770106339000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/30\/5\/1661\/8417249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.14561","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,9,1]]}}}