{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:10Z","timestamp":1791639130067,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3381,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007709","name":"Michigan State University College of Veterinary Medicine Trinket Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies that included limited numbers of affected dogs have suggested basal cortisol concentrations \u226455 nmol\/L (2 \u03bcg\/dL) are sensitive, but nonspecific, for a diagnosis of hypoadrenocorticism. A detailed assessment of the diagnostic utility of basal cortisol concentrations is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To evaluate the utility of basal cortisol concentrations for the diagnosis of hypoadrenocorticism in a large number of dogs, including those with and without serum electrolyte abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Five hundred and twenty-two dogs, including 163 dogs with hypoadrenocorticism, 351 dogs with nonadrenal gland illness, and 8 dogs with equivocal results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Basal and post-ACTH cortisol concentrations and sodium and potassium concentrations were collected from medical records. A receiver operating characteristic (ROC) curve was constructed for basal cortisol concentrations by standard methodologies. Sensitivity, specificity, and predictive values were determined for various cut-points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The area under the ROC curve was 0.988 and was similarly excellent regardless of serum electrolyte concentrations. At the most discriminatory cut-point of 22 nmol\/L (0.8 \u03bcg\/dL), sensitivity and specificity were 96.9 and 95.7%, respectively. A basal cortisol concentration of \u226455 nmol\/L (2 \u03bcg\/dL) resulted in a sensitivity of 99.4%. Conversely, a basal cortisol concentration of \u22645.5 nmol\/L (0.19 \u03bcg\/dL) resulted in a specificity of 99.1%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Similar to findings in previous studies, basal cortisol concentrations &amp;gt;55 nmol\/L (2 \u03bcg\/dL) are useful in excluding a diagnosis of hypoadrenocorticism. Interestingly, excellent specificities and positive predictive values were observed at lower cut-point cortisol concentrations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14589","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T22:49:18Z","timestamp":1476312558000},"page":"1798-1805","source":"Crossref","is-referenced-by-count":60,"title":["Evaluation of Basal Serum or Plasma Cortisol Concentrations for the Diagnosis of Hypoadrenocorticism in Dogs"],"prefix":"10.1093","volume":"30","author":[{"given":"A.J.","family":"Gold","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.K.","family":"Langlois","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , 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