{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:43:33Z","timestamp":1788911013622,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3320,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cavalier King Charles spaniels (CKCSs) are predisposed to degenerative mitral valve disease (DMVD) and studies have indicated a genetic cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 8,860 CKCSs were examined at shows or private clinics from 1991 to 2010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the effects of a breed scheme for CKCS on the age at which a murmur consistent with DMVD was first detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The presence or absence of a murmur consistent with mitral regurgitation was noted and age a murmur was first detected recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 16,887 examinations were performed on 8,860 dogs. The median age dogs developed a murmur were slightly younger in male than female dogs (7.8 versus 8.3 years, 95% confidence interval [CI] 7.4\u20138.1 versus 8.0\u20138.4, P &amp;lt; .001) and cardiologists detected murmurs in younger dogs than did general practitioner (GP) veterinary surgeons (7.2 versus 8.6 years, 95% CI 7.0\u20137.4 versus 8.3\u20138.7 P &amp;lt; .001). In bitches examined by GP vets during the study, there was a significantly increased age of detection of murmurs over time (8.6\u20139.2 years, 95% CI 8.3\u20139.1 and 8.5\u201310.9, P = .001) but not for male dogs examined by GP vets or dogs of either sex examined by cardiologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>This study suggests that the age incidence of murmurs associated with DMVD might be increased by application of breeding guidelines based on auscultation alone. This benefit was only seen in a subgroup and compliance of breeders with this voluntary scheme was poor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14619","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T04:46:50Z","timestamp":1483591610000},"page":"9-14","source":"Crossref","is-referenced-by-count":20,"title":["Degenerative Valvular Disease in the Cavalier King Charles Spaniel: Results of the UK Breed Scheme 1991\u20132010"],"prefix":"10.1093","volume":"31","author":[{"given":"S.","family":"Swift","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Florida , Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Baldin","sequence":"additional","affiliation":[{"name":"Eastcott Veterinary Clinic , 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