{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:12:38Z","timestamp":1783951958271,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3320,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leptospirosis in dogs is occasionally associated with a hemorrhagic syndrome, the pathophysiology of which is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To characterize hematologic, hemostatic, and thromboelastometric abnormalities in dogs with leptospirosis and to study their association with hemorrhagic diatheses and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-five client-owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational single cohort study was conducted. Results from the CBC, coagulation tests (prothrombin, activated partial thromboplastin and thrombin times, fibrinogen, fibrin(ogen) degradation products, and D-dimer concentrations), rotational thromboelastometry (TEM), signalment, hemorrhagic diatheses, occurrence of disseminated intravascular coagulation (DIC) at admission, and survival to discharge were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common hematologic and hemostatic abnormalities were anemia (30\/35), thrombocytopenia (21\/35), and hyperfibrinogenemia (15\/35). Eight dogs were diagnosed with DIC. A normal TEM profile was found in 14 dogs, a hypercoagulable profile in 14 dogs, and a hypocoagulable profile in 7 dogs. The 8 dogs with hemorrhagic diatheses at admission had significantly decreased platelet counts (P = .037) and increased D-dimer concentrations (P = .015) compared with other dogs. Dogs with a hypocoagulable profile exhibited more hemorrhagic diatheses compared with the dogs that had normal and hypercoagulable profiles (P = .049). The mortality rate was lower in dogs with a hypercoagulable profile than in those with a hypocoagulable profile (21% vs 57%; P = .043). Disseminated intravascular coagulation was not a significant prognostic factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Thromboelastometric parameters were altered in dogs with both hypercoagulable and hypocoagulable profiles. A hypocoagulable profile was significantly correlated with hemorrhagic diathesis and higher mortality rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14626","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T12:07:01Z","timestamp":1480680421000},"page":"69-80","source":"Crossref","is-referenced-by-count":25,"title":["Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study"],"prefix":"10.1093","volume":"31","author":[{"given":"A.","family":"Barth\u00e9lemy","sequence":"first","affiliation":[{"name":"Intensive Care Unit (SIAMU), VetAgro Sup campus v\u00e9t\u00e9rinaire de Lyon, Universit\u00e9 de Lyon , Marcy l'Etoile,","place":["France"]},{"name":"Univ Lyon, VetAgro Sup, APCSe , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magnin","sequence":"additional","affiliation":[{"name":"Intensive Care Unit (SIAMU), VetAgro Sup campus v\u00e9t\u00e9rinaire de Lyon, Universit\u00e9 de Lyon , Marcy l'Etoile,","place":["France"]},{"name":"Univ Lyon, VetAgro Sup, APCSe , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pouzot-Nevoret","sequence":"additional","affiliation":[{"name":"Intensive Care Unit (SIAMU), VetAgro Sup campus v\u00e9t\u00e9rinaire de Lyon, Universit\u00e9 de Lyon , Marcy l'Etoile,","place":["France"]},{"name":"Univ Lyon, VetAgro Sup, APCSe , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Bonnet-Garin","sequence":"additional","affiliation":[{"name":"Univ Lyon, VetAgro Sup, APCSe , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hugonnard","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, USC 1233 Emerging Pathogens and Wild Rodents, VetAgro Sup Campus V\u00e9t\u00e9rinaire de Lyon, Universit\u00e9 de Lyon , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Goy-Thollot","sequence":"additional","affiliation":[{"name":"Intensive Care Unit (SIAMU), VetAgro Sup campus v\u00e9t\u00e9rinaire de Lyon, Universit\u00e9 de Lyon , Marcy l'Etoile,","place":["France"]},{"name":"Univ Lyon, VetAgro Sup, APCSe , Marcy l'Etoile,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2026020303063222200_jvim14626-bib-0001","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: A zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"2026020303063222200_jvim14626-bib-0002","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.3390\/ijerph110707242","article-title":"Increasing incidence of canine leptospirosis in Switzerland","volume":"11","author":"Major","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"2026020303063222200_jvim14626-bib-0003","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1939-1676.1992.tb00345.x","article-title":"Canine leptospirosis. 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