{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:33:24Z","timestamp":1781926404665,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3320,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008459","name":"Undergraduate Investigative Medicine Fund of the Faculty of Veterinary Medicine, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood lactate concentration is a marker of tissue perfusion and helps guide therapeutic interventions in critically ill horses. In both humans and dogs, administration of corticosteroids can increase blood lactate concentration, leading to type B hyperlactatemia. This effect could be a consequence of the impact of corticosteroids on glucose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of daily IM dexamethasone administration on blood lactate and glucose concentrations in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nine healthy adult horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, blinded, controlled, cross-over study design was used. Horses were randomly assigned to 1 of 2 groups, either receiving 0.05 mg\/kg of dexamethasone IM or an equivalent volume of saline, daily for 7 days. Blood was collected to determine lactate and glucose concentrations at baseline, 2 hours after the daily injections and 24 hours after the last injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dexamethasone treatment had a statistically significant effect on lactate (P = .006) and glucose (P = .033) concentrations. The least squares mean lactate concentration was 0.93 mmol\/L (95% CI: 0.87\u20130.99) in the dexamethasone group compared to 0.71 mmol\/L (95% CI: 0.70\u20130.73) for the saline group. A positive relationship between blood lactate and glucose concentrations was identified, with a 0.07 mmol\/L (95% CI: 0.05\u20130.09) increase in lactate concentration per unit increase in glucose (P &amp;lt; .0001) concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Dexamethasone induces statistically significant increases in blood lactate and glucose concentrations in healthy horses. Awareness of the potential for corticosteroids to induce type B hyperlactatemia might be important in the management of critically ill horses receiving dexamethasone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14630","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T23:02:59Z","timestamp":1482706979000},"page":"164-169","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses"],"prefix":"10.1093","volume":"31","author":[{"given":"K.","family":"Mizen","sequence":"first","affiliation":[{"name":"Northside Veterinary Clinic , Lethbridge, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Alpine Pet Hospital , Calgary, 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