{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:21Z","timestamp":1787015721384,"version":"build-2736575974"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3261,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coagulation status of dogs with liver disease is difficult to predict using conventional coagulation testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To evaluate thromboelastography (TEG) results and associations with conventional coagulation results and indicators of disease severity and prognosis in dogs with chronic hepatopathies (CH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-one client-owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs with CH were prospectively (10 dogs) and retrospectively (11 dogs) enrolled from 2008 to 2014. Kaolin-activated TEG was performed and compared with reference intervals by t-tests or Mann-Whitney tests. Correlation coefficients for TEG results and conventional coagulation and clinicopathologic results were determined. Significance was set at P &amp;lt; .05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs with CH had significant increases in R (5.30 min vs 4.33 min), K (3.77 min vs 2.11 min), and LY30 (4.77% vs 0.68%) and decreased angles (55.3\u00b0 vs 62.4\u00b0). G value defined 9 of 21, 7 of 21, and 5 of 21 dogs as normocoagulable, hypercoagulable, and hypocoagulable, respectively. G and MA were correlated with fibrinogen (r = 0.68, 0.83), prothrombin time (PT; r = \u22120.51, \u22120.53), and activated partial thromboplastin time (aPTT; r = \u22120.50, \u22120.50). K was correlated with PT (r = 0.75) and protein C activity (r = \u22120.92). Angle was correlated with aPTT (r = \u22120.63). Clinical score was correlated with PT (r = 0.60), MA (r = \u22120.53), and R (r = \u22120.47). Dogs with hyperfibrinolysis (LY30 &amp;gt; 3.04%; 5 of 21) had significantly higher serum transaminase activities. Dogs with portal hypertension had significantly lower G, MA, and angle and prolonged, K, R, and PT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Dogs with CH have variable TEG results. Negative prognostic indicators in CH correlate with hypocoagulable parameters on TEG. Hyperfibrinolysis in dogs with CH is associated with high disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14639","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:08:42Z","timestamp":1484698122000},"page":"419-426","source":"Crossref","is-referenced-by-count":48,"title":["Thromboelastography in Dogs with Chronic Hepatopathies"],"prefix":"10.1093","volume":"31","author":[{"given":"W.","family":"Fry","sequence":"first","affiliation":[{"name":"Massachusetts Veterinary Referral Hospital , Woburn, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lester","sequence":"additional","affiliation":[{"name":"Ocean State Veterinary Specialists, East Greenwich Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Etedali","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies, , Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University Department of Clinical Science, , Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"DeLaforcade","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University Department of Clinical Science, , Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.L.","family":"Webster","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University Department of Clinical Science, , Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2026020922021791600_jvim14639-bib-0001","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.21303","article-title":"Coagulation in Liver Disease Group. 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