{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:35:05Z","timestamp":1770744905453,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3261,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hydroxyethyl starch (HES) solutions may cause acute kidney injury (AKI) in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare AKI grades in 94 dogs exposed and 90 dogs that were unexposed to 6% HES-130\/0.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Dogs receiving 6% HES-130\/0.4 (HES cohort) or crystalloids (unexposed cohort) between 2013 and 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Historical cohort study. Diagnosis, total cumulative dose and total mL\/kg of HES administered, time frame of HES administration and serum creatinine concentrations up to 90 days after initiation of HES treatment were retrospectively reviewed. The AKI grades were retrospectively determined by IRIS guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exposed dogs received a median cumulative dose of 69.4 mL\/kg (range, 2\u2013429 mL\/kg) HES over a median of 4 (range, 1\u201316) days, resulting in a median dose of 20.7 (range, 2\u201387) mL\/kg\/d. Although the cohorts differed in terms of age and diagnosis, AKI grades were not significantly different at the evaluated short- and long-term time points. Results of ordinal logistic regression identified the number of days of HES administration as significantly associated with an increase in AKI grade within 10 days (P = .038), whereas there was no significant association among HES exposure, HES mL\/kg\/d, and an increase in AKI grade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>HES-130\/0.4-treated dogs were not more prone to develop AKI than HES-untreated, but the number of HES days was significantly associated with an increase in AKI grade within 10 days post-HES administration. The time frame of HES treatment should be kept short. Prospective, randomized clinical trials are required to assess the effect of HES on renal function in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14645","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T07:09:03Z","timestamp":1484982543000},"page":"434-441","source":"Crossref","is-referenced-by-count":42,"title":["Changes in Serum Creatinine Concentration and Acute Kidney Injury (AKI) Grade in Dogs Treated with Hydroxyethyl Starch 130\/0.4 From 2013 to 2015"],"prefix":"10.1093","volume":"31","author":[{"given":"N.E.","family":"Sigrist","sequence":"first","affiliation":[{"name":"Vetsuisse Faculty, University of Z\u00fcrich Department of Small Animals, , Z\u00fcrich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"K\u00e4lin","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Z\u00fcrich Department of Small Animals, , Z\u00fcrich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dreyfus","sequence":"additional","affiliation":[{"name":"Section of Epidemiology, Vetsuisse Faculty, University of Z\u00fcrich , Z\u00fcrich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2026020922025459900_jvim14645-bib-0001","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1939-1676.1996.tb02066.x","article-title":"The effect of hetastarch on serum colloid oncotic pressure in hypoalbuminemic dogs","volume":"10","author":"Moore","year":"1996","journal-title":"J Vet Intern Med"},{"key":"2026020922025459900_jvim14645-bib-0002","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/vec.12188","article-title":"Effect of synthetic colloid administration on hemodynamic and laboratory variables in healthy dogs and dogs with systemic inflammation","volume":"24","author":"Gauthier","year":"2014","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922025459900_jvim14645-bib-0003","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1213\/ANE.0b013e3181f2e9b2","article-title":"The effects of 6% hydroxyethyl starch-hypertonic saline in resuscitation of dogs with hemorrhagic shock","volume":"112","author":"Barros","year":"2011","journal-title":"Anesth Analg"},{"key":"2026020922025459900_jvim14645-bib-0004","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2460\/ajvr.2004.65.1189","article-title":"Comparison of lactated Ringer's solution and a physiologically balanced 6% hetastarch plasma expander for the treatment of hypotension induced via blood withdrawal in isoflurane-anesthetized dogs","volume":"65","author":"Muir","year":"2004","journal-title":"Am J Vet Res"},{"key":"2026020922025459900_jvim14645-bib-0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/vec.12283","article-title":"Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care","volume":"25","author":"Adamik","year":"2015","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922025459900_jvim14645-bib-0006","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/vec.12208","article-title":"Hydroxyethyl starch: A review of pharmacokinetics, pharmacodynamics, current products, and potential clinical risks, benefits, and use","volume":"24","author":"Glover","year":"2014","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922025459900_jvim14645-bib-0007","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa070716","article-title":"Intensive insulin therapy and pentastarch resuscitation in severe sepsis","volume":"358","author":"Brunkhorst","year":"2008","journal-title":"N Engl J Med"},{"key":"2026020922025459900_jvim14645-bib-0008","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa1209759","article-title":"Hydroxyethyl starch or saline for fluid resuscitation in intensive care. 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