{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:34:16Z","timestamp":1789187656123,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3261,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AR53890"],"award-info":[{"award-number":["AR53890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32HL007914-08"],"award-info":[{"award-number":["T32HL007914-08"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Musladin-Lueke syndrome (MLS), previously termed Chinese Beagle syndrome, is an autosomal-recessive connective tissue disorder characterized by extensive fibrosis of the skin and joints that was first identified in Beagles in the 1970s. Recent research identified a founder mutation (c.660C&amp;gt;T; p.R221C) in the ADAMTSL2 gene in Beagles with MLS. Here, we report the detailed clinical phenotype and laboratory findings in 2 Beagles affected with MLS. We discuss these findings in relation to the human disorder geleophysic dysplasia (GD), which also arises from recessive ADAMTSL2 mutations, and recent findings in Adamtsl2-deficient mice.<\/jats:p>","DOI":"10.1111\/jvim.14654","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T08:48:45Z","timestamp":1486111725000},"page":"532-538","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Phenotype of Musladin-Lueke Syndrome in 2 Beagles"],"prefix":"10.1093","volume":"31","author":[{"given":"R.A.","family":"Packer","sequence":"first","affiliation":[{"name":"Purdue University Department of Veterinary Clinical Sciences, , West Lafayette, IN"},{"name":"Purdue University Department of Basic Medical Sciences, , West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Logan","sequence":"additional","affiliation":[{"name":"Purdue University Department of Veterinary Clinical Sciences, , West Lafayette, IN"},{"name":"Purdue University Department of Basic Medical Sciences, , West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.T.","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California - San Diego Department of Pathology, , La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Apte","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner Research Institute Department of Biomedical Engineering, , Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bader","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner Research Institute Department of Biomedical Engineering, , Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"Shelton","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California - San Diego Department of Pathology, , La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2026020922054719500_jvim14654-bib-0001","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2460\/javma.1995.206.02.194","article-title":"Vertebral scale system to measure canine heart size in radiographs","volume":"206","author":"Buchanan","year":"1995","journal-title":"J Am Vet Med 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