{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:35:31Z","timestamp":1790091331032,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The signalment, clinicopathologic, bacteriological, histopathological, ultrasonographic characteristics, and the treatment and outcomes of adult cattle with cholangiohepatitis are poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirteen Holstein cows with cholangiohepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study of medical records of cattle admitted to the CHUV and the AVC between 1992 and 2012 and 2000 and 2012, respectively, for cattle older than 3 months of age with a histopathological diagnosis of cholangiohepatitis. Cholangiohepatitis was defined as the presence of portal inflammation surrounding or infiltrating bile ducts, with or without epithelial damage, and extending into the adjacent lobules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the time of diagnosis of cholangiohepatitis, cows had decreased appetite (n = 7) or were anorectic (n = 6), had fever (n = 5), and had tachycardia (n = 8). Icterus was detected in 5 cows. Yellow discoloration was identified on the skin of the udder (n = 3), conjunctiva (n = 2), and vulva (n = 1). There was leukocytosis (n = 6), neutrophilia (n = 9), and hyperfibrinogenemia (n = 8). Alteration in the serum biochemistry profile included hyperglobulinemia (n = 8), hypoalbuminemia (n = 10), increased activity of GGT (n = 12), AST (n = 8), and ALP (n = 10), and hyperbilirubinemia (n = 10). Histopathological diagnosis included mild, subacute, nonsuppurative cholangiohepatitis (n = 4), mild suppurative cholangiohepatitis (n = 4), mild mixed (neutrophilic and lymphocytic) cholangiohepatitis (n = 3), and moderate, chronic, nonsuppurative cholangiohepatitis (n = 1). Six cows were discharged from the hospital, and 7 were euthanized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Cholangiohepatitis is a rare condition in adult cattle. Antemortem diagnosis can be challenging because clinical signs are unspecific.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14675","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:12:54Z","timestamp":1489709574000},"page":"922-927","source":"Crossref","is-referenced-by-count":5,"title":["Cholangiohepatitis in Dairy Cattle: 13 Cases"],"prefix":"10.1093","volume":"31","author":[{"given":"D.E.","family":"Gomez","sequence":"first","affiliation":[{"name":"Atlantic Veterinary College (AVC), University of Prince Edward Island Department of Health Management, , Charlottetown, PE,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Saint-Hyacinthe, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Francoz","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Saint-Hyacinthe, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Desrochers","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Saint-Hyacinthe, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Saint-Hyacinthe, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fecteau","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Saint-Hyacinthe, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2026020303192432900_jvim14675-bib-0001","first-page":"200","article-title":"Rebhun's Diseases of Dairy Cattle","author":"Van Metre","year":"2008","edition":"2"},{"key":"2026020303192432900_jvim14675-bib-0002","first-page":"337","article-title":"Jubb, Kennedy & Palmer's Pathology of Domestic Animals","author":"Maxi","year":"2007","edition":"6"},{"key":"2026020303192432900_jvim14675-bib-0003","first-page":"869","article-title":"Large Animal Internal Medicine","author":"Davis","year":"2015","edition":"5"},{"key":"2026020303192432900_jvim14675-bib-0004","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1177\/0300985813513042","article-title":"Bile duct lesions associated with turnip (Brassica rapa) photosensitization compared with those due to sporidesmin toxicosis in dairy cows","volume":"51","author":"Collett","year":"2014","journal-title":"Vet Pathol"},{"key":"2026020303192432900_jvim14675-bib-0005","first-page":"515","article-title":"Chronic cholangiohepatitis in a dairy cow. 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