{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:49:14Z","timestamp":1783979354992,"version":"3.55.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The median age at presentation for dogs with patent ductus arteriosus (PDA) is &amp;lt;6\u00a0months of age, and closure is associated with a decrease in heart size and increased survival time, which are not well described in older dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the clinical characteristics of dogs with PDA \u22655\u00a0years of age at the time of presentation to a veterinary referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>35 client-owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PDA was diagnosed at a median age of 7.4\u00a0years (range, 5.1\u201312.3\u00a0years). Females represented 23\/35 (65.7%) of the patients. Concurrent heart disease included degenerative mitral valve disease (DMVD; 13), arrhythmias (11), pulmonary hypertension (7), and other congenital defects (2). Cardiomegaly was documented in the majority of dogs consisting of left ventricular enlargement (91%) and left atrial enlargement (86%). Median vertebral heart size in 24 dogs was 12.9 (range, 10.7\u201318.2). The PDA shunt direction was left-to-right in 33 and bidirectional in 2 dogs. Closure was performed in 26 dogs, including 4 with pulmonary hypertension. In 10 dogs receiving furosemide pre-operatively for management of heart failure, furosemide was discontinued (8) or the dosage decreased (2) at the time of discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Adult dogs can present with a left-to-right shunting PDA that results in cardiomegaly and clinical signs that can improve or resolve with PDA closure. This improvement is also apparent in dogs with PDA complicated by DMVD. Pulmonary hypertension that does not result in complete right-to-left shunting should not be considered a contraindication to closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14689","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T07:57:57Z","timestamp":1491379077000},"page":"685-690","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Characteristics of Adult Dogs More Than 5 Years of Age at Presentation for Patent Ductus Arteriosus"],"prefix":"10.1093","volume":"31","author":[{"given":"B.G.","family":"Boutet","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences and the Michael E. DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, , College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-3894","authenticated-orcid":false,"given":"A.B.","family":"Saunders","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences and the Michael E. DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, , College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"Gordon","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences and the Michael E. DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, , College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"issue":"3","key":"2026020303191445400_jvim14689-bib-0001","first-page":"S125","article-title":"Echocardiography for patent ductus arteriosus including closure in adults","volume":"32","author":"Chugh","year":"2015","journal-title":"Echocardiography"},{"key":"2026020303191445400_jvim14689-bib-0002","first-page":"846","article-title":"The Practice of Clinical Echocardiography","author":"Valente","year":"2012"},{"key":"2026020303191445400_jvim14689-bib-0003","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/echo.12943","article-title":"The various hemodynamic profiles of the patent ductus arteriosus in 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