{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:16:18Z","timestamp":1790813778215,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Cummings Companion Animal Health Fund"},{"name":"Barkley Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reductions in N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations after treatment have been associated with improved survival in people with congestive heart failure (CHF), but have not been reported in cats with CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate changes in NT-proBNP concentrations in cats with CHF after treatment and determine whether serial NT-proBNP measurements provide prognostic information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-one client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, observational study in cats with new onset CHF secondary to cardiomyopathy. Concentrations of NT-proBNP were measured within 4 hours of admission to the hospital, on the day of discharge, and at re-evaluation 7\u201310 days later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median NT-proBNP concentrations decreased significantly from admission (1,713 pmol\/L [range, 160\u20133,784 pmol\/L]) to discharge (902 pmol\/L [range, 147\u20133,223 pmol\/L]); P = .005) and from admission to re-evaluation (1,124 pmol\/L [range, 111\u20132,727 pmol\/L]; P = .024). Median survival time was 109 days (range, 1\u2013709 days), with 5 cats still alive at the time of analysis. Cats with a larger percent decrease in NT-proBNP from admission to discharge had a longer survival time (P = .048). Cats with evidence of active CHF at the time of re-evaluation (P = .010) and cats whose owners had difficulty administering medications (P = .045) had shorter survival times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Cats with a larger percent decrease in NT-proBNP during hospitalization and no evidence of CHF at the time of re-evaluation had longer survival times. Additional studies are needed to determine whether NT-proBNP can help guide treatment in cats with CHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14690","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T12:54:00Z","timestamp":1490964840000},"page":"678-684","source":"Crossref","is-referenced-by-count":18,"title":["Association between Survival Time and Changes in NT-proBNP in Cats Treated for Congestive Heart Failure"],"prefix":"10.1093","volume":"31","author":[{"given":"K.V.","family":"Pierce","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, MA"},{"name":"BluePearl Veterinary Partners , 180 Bear Hill Road Waltham, MA 02451"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Rush","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University Department of 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