{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:30:34Z","timestamp":1788849034524,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteosarcoma (OSA) should be differentiated from other less frequent primary bone neoplasms, metastatic disease, and tumor-like lesions, as treatment and prognosis can vary accordingly. Hence, a preoperative histologic diagnosis is generally preferred. This requires collection of multiple biopsies under general anesthesia, with possible complications, including pathological fractures. Fine-needle aspiration cytology would allow an earlier diagnosis with a significant reduction of discomfort and morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to compare the accuracy of cytological and histologic biopsies in the diagnosis of canine osteodestructive lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-eight dogs with bone lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Accuracy was assessed by comparing the former diagnosis with the final histologic diagnosis on surgical or post-mortem samples or, in the case of non-neoplastic lesions, with follow-up information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 50 primary malignant bone tumors (40 OSAs, 5 chondrosarcomas, 2 fibrosarcomas, and 3 poorly differentiated sarcomas), 6 carcinoma metastases, and 12 non-neoplastic lesions. Accuracy was 83% for cytology (sensitivity, 83.3%; specificity, 80%) and 82.1% for histology (sensitivity, 72.2%; specificity, 100%). Tumor type was correctly identified cytologically and histologically in 50 and 55.5% of cases, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The accuracy of cytology was similar to histology, even in the determination of tumor type. In no case was a benign lesion diagnosed as malignant on cytology. This is the most important error to prevent, as treatment for malignant bone tumors includes aggressive surgery. Being a reliable diagnostic method, cytology should be further considered to aid decisions in the preoperative setting of canine bone lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14696","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:43:47Z","timestamp":1491399827000},"page":"864-871","source":"Crossref","is-referenced-by-count":39,"title":["Comparative Assessment of the Accuracy of Cytological and Histologic Biopsies in the Diagnosis of Canine Bone Lesions"],"prefix":"10.1093","volume":"31","author":[{"given":"S.","family":"Sabattini","sequence":"first","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Renzi","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Buracco","sequence":"additional","affiliation":[{"name":"University of Turin Department of Veterinary Sciences, , Turin,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Defourny","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo , Teramo,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garnier-Moiroux","sequence":"additional","affiliation":[{"name":"University of Turin Department of Veterinary Sciences, , Turin,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Capitani","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-7329","authenticated-orcid":false,"given":"G.","family":"Bettini","sequence":"additional","affiliation":[{"name":"University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2026020303190619800_jvim14696-bib-0001","first-page":"463","article-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Ehrhart","year":"2013","edition":"5"},{"key":"2026020303190619800_jvim14696-bib-0002","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2460\/javma.1988.193.02.205","article-title":"Jamshidi needle biopsy for diagnosis of bone lesions in small animals","volume":"193","author":"Powers","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303190619800_jvim14696-bib-0003","first-page":"245","article-title":"Tumors in Domestic Animals","author":"Thompson","year":"2002","edition":"4"},{"key":"2026020303190619800_jvim14696-bib-0004","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1939-1676.2000.tb02265.x","article-title":"Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: A pilot study","volume":"14","author":"Chun","year":"2000","journal-title":"J Vet Intern Med"},{"key":"2026020303190619800_jvim14696-bib-0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1939-1676.2003.tb02434.x","article-title":"Carboplatin and doxorubicin combination chemotherapy for the treatment of appendicular osteosarcoma in the dog","volume":"17","author":"Bailey","year":"2003","journal-title":"J Vet Intern Med"},{"key":"2026020303190619800_jvim14696-bib-0006","first-page":"540","article-title":"Alternating carboplatin and doxorubicin as adjunctive chemotherapy to amputation or limb-sparing surgery in the treatment of appendicular osteosarcoma in dogs","volume":"18","author":"Kent","year":"2004","journal-title":"J Vet Intern Med"},{"key":"2026020303190619800_jvim14696-bib-0007","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5326\/JAAHA-MS-6315","article-title":"Canine osteosarcoma treated by post-amputation sequential accelerated doxorubicin and carboplatin chemotherapy: 38 cases","volume":"52","author":"Frimberger","year":"2016","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303190619800_jvim14696-bib-0008","first-page":"81","article-title":"Chondrosarcoma: A retrospective study of 97 dogs (1987\u20131990)","volume":"30","author":"Popovitch","year":"1994","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303190619800_jvim14696-bib-0009","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2106\/00004623-199605000-00004","article-title":"The hazards of the biopsy, revisited. 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