{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:31:37Z","timestamp":1780597897510,"version":"3.54.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The assessment of left atrial (LA) function by 2-dimensional speckle tracking echocardiography (STE) holds important clinical implications in human medicine. Few similar data are available in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess LA function by STE in dogs with and without myxomatous mitral valve disease (MMVD), analyzing LA areas, systolic function, and strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred and fifty dogs were divided according to the American College of Veterinary Internal Medicine classification of heart failure: 23 dogs in class A, 52 in class B1, 36 in class B2, and 39 in class C + D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study. Conventional morphologic and Doppler variables, LA areas, and STE-based LA strain analysis were performed in all dogs and results were compared among groups. Correlation analysis was carried out between LA STE variables and other echocardiographic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Variability study showed good reproducibility for all the tested variables (coefficient of variation &amp;lt;16%). Left atrial areas, fractional area change, peak atrial longitudinal strain (PALS), peak atrial contraction strain, and contraction strain index (CSI) differed significantly between groups B2 and C + D and all the other groups (overall P &amp;lt; .001), whereas only PALS differed between groups B1 and A (P = .01). Left atrial areas increased with progression of the disease, whereas LA functional parameters decreased. Only CSI increased nonsignificantly from group A to group B1 and then progressively decreased. Thirty-one significant correlations (P &amp;lt; .001, r &amp;gt; .3) were found between conventional left heart echocardiographic variables and LA areas and strain variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Left atrial STE analysis provides useful information on atrial function in the dog, highlighting a progressive decline in atrial function with worsening of MMVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14722","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T00:35:54Z","timestamp":1493426154000},"page":"641-649","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of Left Atrial Deformation and Function by 2-Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-1856","authenticated-orcid":false,"given":"M.","family":"Baron Toaldo","sequence":"first","affiliation":[{"name":"Alma Mater Studiorum \u2013 University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Romito","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum \u2013 University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Guglielmini","sequence":"additional","affiliation":[{"name":"Production and Health, University of Padova Department of Animal Medicine, , Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diana","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum \u2013 University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.","family":"Pelle","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum \u2013 University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Contiero","sequence":"additional","affiliation":[{"name":"Production and Health, University of Padova Department of Animal Medicine, , Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cipone","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum \u2013 University of Bologna Department of Veterinary Medical Sciences, , Bologna,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2026020303190270300_jvim14722-bib-0001","first-page":"33","article-title":"Diastology. 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