{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:35:15Z","timestamp":1770150915869,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2955,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Devry Education Group"},{"name":"Ross University School of Veterinary Medicine intramural grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Minocycline has been used in the treatment of Ehrlichia canis infection in dogs as an alternative to doxycycline, the recommended treatment. However, efficacy of this alternative therapy is unknown.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess the efficacy of minocycline in the treatment of natural occurring E.\u00a0canis infection in dogs.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Ten privately owned dogs of mixed breed positive for E.\u00a0canis by blood PCR.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective, randomized clinical study. Dogs positive for E.\u00a0canis by PCR were housed in a kennel environment and randomly allocated to receive doxycycline 10\u00a0mg\/kg bodyweight PO once daily (\u201cgold standard\u201d control group) or minocycline (extralabel) 10\u00a0mg\/kg bodyweight PO twice daily (treatment test group) for 28\u00a0days. Blood, analyzed by PCR to determine the presence or absence of E.\u00a0canisDNA, was collected weekly during treatment starting on the first day of treatment and including through day 35, 7\u00a0days after the last treatment.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In both groups, one dog tested negative after 7\u00a0days of treatment. For the doxycycline group, the latest time to a negative PCR test was after 3\u00a0weeks of treatment. For the minocycline group, the latest time was on day 28 of treatment. All dogs tested negative 7\u00a0days after the end of treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion and Clinical Importance<\/jats:title>\n Minocycline can be an effective alternative to doxycycline for clearing E.\u00a0canis from the blood in nonacute infections.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.14842","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:08:42Z","timestamp":1512173322000},"page":"217-221","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Minocycline in Naturally Occurring Nonacute\n Ehrlichia canis<\/i>\n Infection in Dogs"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-7909","authenticated-orcid":false,"given":"S.","family":"Jenkins","sequence":"first","affiliation":[{"name":"One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine , Basseterre, St. Kitts,","place":["West Indies"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-3140","authenticated-orcid":false,"given":"J.K.","family":"Ketzis","sequence":"additional","affiliation":[{"name":"One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine , Basseterre, St. Kitts,","place":["West Indies"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dundas","sequence":"additional","affiliation":[{"name":"One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine , Basseterre, St. Kitts,","place":["West Indies"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Scorpio","sequence":"additional","affiliation":[{"name":"One Health Center for Zoonoses and Tropical Veterinary Medicine, Ross University School of Veterinary Medicine , Basseterre, St. Kitts,","place":["West Indies"]},{"name":"Vaccine Research Center, National Institutes of Health , Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2026020303245006400_jvim14842-bib-0001","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vetpar.2007.12.030","article-title":"The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): From taxonomy to control","volume":"152","author":"Dantas-Torres","year":"2008","journal-title":"Vet Parasitol"},{"key":"2026020303245006400_jvim14842-bib-0002","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/JCM.37.9.2745-2749.1999","article-title":"Recent advances in determining the pathogenesis of canine monocytic ehrlichiosis","volume":"37","author":"Harrus","year":"1999","journal-title":"J Clin Microbiol"},{"key":"2026020303245006400_jvim14842-bib-0003","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13071-015-0649-0","article-title":"Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe","volume":"8","author":"Sainz","year":"2015","journal-title":"Parasit Vectors"},{"key":"2026020303245006400_jvim14842-bib-0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-3305-7-8","article-title":"Insecticide\/acaricide resistance in fleas and ticks infesting dogs and cats","volume":"7","author":"Coles","year":"2014","journal-title":"Parasit Vectors"},{"key":"2026020303245006400_jvim14842-bib-0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1892\/0891-6640(2002)016<0309:CSOEDO>2.3.CO;2","article-title":"Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM. 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