{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:16:35Z","timestamp":1780755395922,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2955,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sialocele is a collection of saliva that has leaked from a damaged salivary gland or duct and is surrounded by granulation tissue. Surgery is the recognized first-line treatment. Recurrence rate after surgery is 5\u201314%. Salivary gland tissue is very sensitive to radiation therapy (RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Radiation therapy will be useful for the treatment of sialocele. The aims were to characterize response rate and clinical course of dogs with sialocele treated with RT and to determine a starting dose for clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eleven dogs with sialocele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study of response and outcome after RT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All dogs had cervical sialocele. Seven dogs (63.6%) were treated with 3 weekly fractions of 4 Gray (Gy); (total dose, 12 Gy). Three dogs (27.3%) received 4 fractions of 4 Gy (16 Gy) and 1 dog received 5 fractions of 4 Gy (20 Gy) on a Monday-Wednesday-Friday schedule. Six dogs (54%) achieved a complete response (CR), and 5 dogs (45%) achieved a partial response (PR). Three dogs had progression of their sialocele 2, 3, and 9 months after RT; all three had received 12 Gy initially and 2 received 2 additional fractions of 4 Gy (cumulative total dose, 20 Gy) and subsequently achieved remission for &amp;gt;2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Radiation therapy is useful for the treatment of recurrent sialocele refractory to surgical management and a minimum total dose of 16 or 20 Gy in 4 Gy fractions appears effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14868","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T10:08:39Z","timestamp":1510567719000},"page":"107-110","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of Radiation Therapy for the Treatment of Sialocele in Dogs"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-3934","authenticated-orcid":false,"given":"V.J.","family":"Poirier","sequence":"first","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University , Palmerston North,","place":["New Zealand"]},{"name":"Animal Cancer Centre, Ontario Veterinary College, University of Guelph , Guelph,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mayer-Stankeov\u00e1","sequence":"additional","affiliation":[{"name":"AOI Animal Oncology and Imaging Center , Hunenberg,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buchholz","sequence":"additional","affiliation":[{"name":"AOI Animal Oncology and Imaging Center , Hunenberg,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Vail","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and the Carbone Cancer Center, University of Wisconsin-Madison , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kaser Hotz","sequence":"additional","affiliation":[{"name":"AOI Animal Oncology and Imaging Center , Hunenberg,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2026020303250854300_jvim14868-bib-0001","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/vr.78.14.488","article-title":"Salivary cysts in the dog: Identification of sub-lingual duct defects by sialography","volume":"78","author":"Glen","year":"1966","journal-title":"Vet 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