{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:36:17Z","timestamp":1792215377955,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2955,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020968","name":"Boehringer Ingelheim Animal Health GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and cardiomegaly have not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effect of pimobendan on clinical variables and the relationship between a change in heart size and the time to congestive heart failure (CHF) or cardiac-related death (CRD) in dogs with MMVD and cardiomegaly. To determine whether pimobendan-treated dogs differ from dogs receiving placebo at onset of CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Three hundred and fifty-four dogs with MMVD and cardiomegaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Prospective, blinded study with dogs randomized (ratio 1:1) to pimobendan (0.4\u20130.6\u00a0mg\/kg\/d) or placebo. Clinical, laboratory, and heart-size variables in both groups were measured and compared at different time points (day 35 and onset of CHF) and over the study duration. Relationships between short-term changes in echocardiographic variables and time to CHF or CRD were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At day 35, heart size had reduced in the pimobendan group: median change in (\u0394) LVIDDN \u22120.06 (IQR: \u22120.15 to +0.02), P\u00a0&amp;lt;\u00a00.0001, and LA:Ao \u22120.08 (IQR: \u22120.23 to +0.03), P\u00a0&amp;lt;\u00a00.0001. Reduction in heart size was associated with increased time to CHF or CRD. Hazard ratio for a 0.1 increase in \u0394LVIDDN was 1.26, P\u00a0=\u00a00.0003. Hazard ratio for a 0.1 increase in \u0394LA:Ao was 1.14, P\u00a0=\u00a00.0002. At onset of CHF, groups were similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Pimobendan treatment reduces heart size. Reduced heart size is associated with improved outcome. At the onset of CHF, dogs treated with pimobendan were indistinguishable from those receiving placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.14885","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T23:23:15Z","timestamp":1512602595000},"page":"72-85","source":"Crossref","is-referenced-by-count":73,"title":["Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-4364","authenticated-orcid":false,"given":"A.","family":"Boswood","sequence":"first","affiliation":[{"name":"The Royal Veterinary College department of Veterinary Clinical Sciences, , Hatfield, 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