{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:14:15Z","timestamp":1770221655604,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2955,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning","doi-asserted-by":"publisher","award":["221-2013-606"],"award-info":[{"award-number":["221-2013-606"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Streptococcus equi ssp. equi causes characteristic clinical signs that are most severe in young horses, including fever, purulent nasal discharge, and lymph node abscessation in the head region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Clinical, serologic, and microbiologic factors related to unexpectedly mild disease severity in a natural outbreak of strangles in immunologically na\u00efve weanlings were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One-hundred and twelve warmblood weanlings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective longitudinal observational study of a natural outbreak of strangles. The entire cohort was examined at the peak of the outbreak by deep nasal swabs for culture and quantitative PCR (qPCR) for the presence of S.\u00a0equi and clinically and serologically in a sequential manner by an optimized ELISA from the index case throughout the outbreak until resolution. Descriptive statistics were calculated and comparisons made using a nondirectional Wilcoxon signed-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Outbreak morbidity was 53%, with 9 of 14 horses culture positive and 26 of 53 horses qPCR positive for S.\u00a0equi lacking clinical signs characteristic of strangles. By resolution, 91 of 112 had seroconverted to Antigen A by ELISA but seroconversion to antigen C (part of the SeM protein) was minimal. Sequencing of the isolates detected no alterations in the SeM protein, but identified a 61\u00a0bp deletion in the gene SEQ_0402.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Absence of clinical signs alone in na\u00efve horses may be an insufficient criterion to release horses from strangles quarantine measures. Restricted seroconversion to antigen C may have been associated with decreased clinical severity. The role of a minor gene deletion in SEQ_0402 in the virulence of S.\u00a0equi warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15037","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T14:03:44Z","timestamp":1517234624000},"page":"459-464","source":"Crossref","is-referenced-by-count":23,"title":["Decreased Clinical Severity of Strangles in Weanlings Associated with Restricted Seroconversion to Optimized\n                    <i>Streptococcus equi<\/i>\n                    ssp\n                    <i>equi<\/i>\n                    Assays"],"prefix":"10.1093","volume":"32","author":[{"given":"L.","family":"Tscheschlok","sequence":"first","affiliation":[{"name":"Equine Veterinary Clinic , Destedt,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Venner","sequence":"additional","affiliation":[{"name":"Equine Veterinary Clinic , Destedt,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Steward","sequence":"additional","affiliation":[{"name":"Animal Health Trust Department of Bacteriology, , Newmarket,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"B\u00f6se","sequence":"additional","affiliation":[{"name":"Labor Dr. B\u00f6se GmbH , Harsum,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Riihim\u00e4ki","sequence":"additional","affiliation":[{"name":"Swedish University of Agricultural Sciences , Uppsala,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-0363","authenticated-orcid":false,"given":"J.","family":"Pringle","sequence":"additional","affiliation":[{"name":"Swedish University of Agricultural Sciences , 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