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(2) To identify differences in metabolites in ponies with insulin dysregulation, obesity, or history of laminitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty Welsh Ponies (mean\u2009\u00b1\u2009SD; 13.8\u2009\u00b1\u20099.0 years) classified as non-insulin dysregulated [CON] (n\u2009=\u200910, insulin\u2009&amp;lt;\u200930 mU\/L) or insulin dysregulated [ID] (n\u2009=\u200910, insulin\u2009&amp;gt;\u200960 mU\/L) at 75 minutes after administration of Karo syrup, obese (n\u2009=\u20096) or nonobese (n\u2009=\u200914), and history of laminitis (n\u2009=\u20099) or no history of laminitis (n\u2009=\u200911).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case-control study. Metabolomic analysis was performed on serum obtained at 0 minutes (baseline) and 75 minutes during the OST. Data were analyzed with multivariable mixed linear models with significance set at P\u2009\u2264\u2009.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Metabolomic analysis of 646 metabolites (506 known) detected significant metabolite differences. At baseline, 55 metabolites (insulin response), 91 metabolites (obesity status), and 136 metabolites (laminitis history) were different. At 75 minutes, 51 metabolites (insulin response), 102 metabolites (obesity status), and 124 metabolites (laminitis history) were different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Use of metabolomics could have diagnostic utility for early detection of EMS and provide new knowledge regarding the pathophysiology of metabolic perturbations associated with this condition that might lead to improved clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15095","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T20:21:06Z","timestamp":1521836466000},"page":"1215-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Metabolic perturbations in Welsh Ponies with insulin dysregulation, obesity, and laminitis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-4685","authenticated-orcid":false,"given":"Sarah I.","family":"Jacob","sequence":"first","affiliation":[{"name":"Michigan State University College of Veterinary Medicine ,Large Animal Clinical Sciences, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Murray","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Veterinary Medicine, Veterinary Population Medicine ,St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron K.","family":"Rendahl","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Veterinary Medicine, Veterinary Population Medicine ,St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Geor","sequence":"additional","affiliation":[{"name":"Massey University College of 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