{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:57:01Z","timestamp":1792112221521,"version":"4.4.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2835,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D09FE-026"],"award-info":[{"award-number":["D09FE-026"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003516","name":"Winn Feline Foundation","doi-asserted-by":"publisher","award":["W 09-017"],"award-info":[{"award-number":["W 09-017"]}],"id":[{"id":"10.13039\/100003516","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D09FE\u2010026"],"award-info":[{"award-number":["D09FE\u2010026"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003516","name":"Winn Feline Foundation","doi-asserted-by":"publisher","award":["W 09\u2010017"],"award-info":[{"award-number":["W 09\u2010017"]}],"id":[{"id":"10.13039\/100003516","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicenter, longitudinal, cohort study. Cats from 21 countries were followed through medical record review and owner or referring veterinarian interviews. Data were analyzed to compare long-term outcomes, incidence, and risk for congestive heart failure (CHF), arterial thromboembolism (ATE), and cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, CHF, ATE, or both occurred in 30.5% and cardiovascular death in 27.9% of 1008 HCM\/HOCM cats. Risk assessed at 1, 5, and 10 years after study entry was 7.0%\/3.5%, 19.9%\/9.7%, and 23.9%\/11.3% for CHF\/ATE, and 6.7%, 22.8%, and 28.3% for cardiovascular death, respectively. There were no statistically significant differences between HOCM compared with HCM for cardiovascular morbidity or mortality, time from diagnosis to development of morbidity, or cardiovascular survival. Cats that developed cardiovascular morbidity had short survival (mean\u2009\u00b1\u2009standard deviation, 1.3\u2009\u00b1\u20091.7 years). Overall, prolonged longevity was recorded in a minority of preclinical HCM\/HOCM cats with 10% reaching 9-15 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Preclinical HCM\/HOCM is a global health problem of cats that carries substantial risk for CHF, ATE, and cardiovascular death. This finding underscores the need to identify therapies and monitoring strategies that decrease morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15122","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T17:29:57Z","timestamp":1523899797000},"page":"930-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-0573","authenticated-orcid":false,"given":"Philip R.","family":"Fox","sequence":"first","affiliation":[{"name":"The Animal Medical Center Department of Cardiology and Caspary Research Institute, ,New York, New York,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Keene","sequence":"additional","affiliation":[{"name":"North Carolina State University Department of Clinical Sciences, ,Raleigh, North Carolina,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lamb","sequence":"additional","affiliation":[{"name":"Lamb Consulting ,Minneapolis, Minnesota,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten A.","family":"Schober","sequence":"additional","affiliation":[{"name":"The Ohio State University Department of Veterinary Clinical Sciences, ,Columbus, Ohio,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Chetboul","sequence":"additional","affiliation":[{"name":"Alfort Cardiology Unit, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort ,Maisons-Alfort Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Luis Fuentes","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Department of Veterinary Clinical Sciences and Services, ,Hatfield, Hertfordshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Wess","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Ludwig-Maximilians University ,Munich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie Rose","family":"Payne","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College Department of Veterinary Clinical Sciences and Services, ,Hatfield, Hertfordshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Purdue University Department of Veterinary Clinical Sciences, ,West Lafayette, Indiana,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Motsinger-Reif","sequence":"additional","affiliation":[{"name":"North Carolina State University Department of Statistics, ,Raleigh, North Carolina,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-023X","authenticated-orcid":false,"given":"Jens","family":"H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[{"name":"Swedish University of Agricultural Sciences Department of Clinical Sciences, ,Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Trehiou-Sechi","sequence":"additional","affiliation":[{"name":"Alfort Cardiology Unit, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort ,Maisons-Alfort Cedex,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Fine-Ferreira","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, ,Columbia, Missouri,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid K.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Advanced Veterinary Care Center ,Lawndale, California,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-0496","authenticated-orcid":false,"given":"Pamela M.","family":"Lee","sequence":"additional","affiliation":[{"name":"The Animal Medical Center Department of Cardiology and Caspary Research Institute, ,New York, New York,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manreet K.","family":"Singh","sequence":"additional","affiliation":[{"name":"William R. 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