{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:18:21Z","timestamp":1782296301194,"version":"3.54.5"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2835,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Veterinary Clinical Sciences Incentive Grant, Iowa State University, College of Veterinary Medicine","award":["290-05-30 00-0001"],"award-info":[{"award-number":["290-05-30 00-0001"]}]},{"name":"Veterinary Clinical Sciences Incentive Grant, Iowa State University, College of Veterinary Medicine","award":["290-05-30 00-0001"],"award-info":[{"award-number":["290-05-30 00-0001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixteen dogs with idioptahic IBD and 13 healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum CRP (median 3.5 mg\/L; range: 0.1-52.4 mg\/L), fecal cCP (median 92.3 \u03bcg\/g; range: 0.03-637.5 \u03bcg\/g), and CIBDAI scores significantly increased in dogs with IBD before treatment compared with serum CRP (median 0.2 mg\/L; range: 0.1-11.8 mg\/L; P\u2009&amp;lt;\u2009.001), fecal cCP (median 0.67 \u03bcg\/g; range: 0.03-27.9 \u03bcg\/g; P\u2009&amp;lt;\u2009.001) and CIBDAI (P\u2009&amp;lt;\u2009.001) after treatment. No significant associations between CIBDAI scores and before or after treatment serum biomarkers. There was a significant association between fecal cCP and CIBDAI scores before treatment (rho\u2009=\u20090.60, P\u2009=\u2009.01). CRP and fecal cCP significantly decreased after treatment (median 3.5 mg\/L v. 0.2 mg\/L; P\u2009&amp;lt;\u2009.001 and 92.3 \u03bcg\/g v. 0.67 \u03bcg\/g; P = .001, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Our data indicate that measurement of fecal cCP concentration is a useful biomarker for noninvasive evaluation of intestinal inflammation. Dogs with severe signs of GI disease more often have abnormal markers than dogs having less severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15123","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T18:16:08Z","timestamp":1523038568000},"page":"999-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-9122","authenticated-orcid":false,"given":"Cristiane C.","family":"Otoni","sequence":"first","affiliation":[{"name":"VCA Arboretum View Animal Hospital, 2551 Warrenville Road Internal Medicine Department, ,Downers Grove, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-5157","authenticated-orcid":false,"given":"Romy M.","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , Texas"},{"name":"Small Animal Clinic, College of Veterinary Medicine, University of Leipzig Department of Small Animal Medicine, ,Leipzig, Saxony,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00eda-Sancho","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Complutense University of Madrid Department of Animal Medicine and Surgery, ,Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Sainz","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Complutense University of Madrid Department of Animal Medicine and Surgery, ,Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Ackermann","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University Department of Veterinary Pathology, ,Ames, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , 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