{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:21:34Z","timestamp":1784323294021,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2835,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Clinically healthy cats (n\u2009=\u200988) and cats with HCM (n\u2009=\u200993).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography. Plasma cTnI concentrations were analyzed by a commercial laboratory. Receiver-operating characteristic curve analysis was used to evaluate the accuracy of plasma cTnI concentrations to detect HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median cTnI concentration was 0.027 ng\/mL (interquartile range, 0.012-0.048 ng\/mL) in healthy cats. Concentrations were significantly higher in diseased cats than in healthy controls, and concentrations were significantly higher in cats with heart failure than in asymptomatic cats. A plasma cTnI concentration of 0.163 ng\/mL had a sensitivity of 62.0% and specificity of 100% when used to distinguish normal cats from asymptomatic HCM cats without left atrial dilatation. A cutoff of 0.234 ng\/mL had high sensitivity (95.0%) and specificity (77.8%) for assessing heart failure. The areas under the receiver-operating characteristic curves were 0.85 and 0.93, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Increased cTnI concentrations reflect the severity of HCM. If other causes of cardiac injury are ruled out, plasma cTnI concentration may be useful for predicting the severity of HCM in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15131","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T17:28:45Z","timestamp":1523899725000},"page":"922-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-0600","authenticated-orcid":false,"given":"Yasutomo","family":"Hori","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Rakuno Gakuen University, 582 Midori-machi, Bunkyodai ,Ebetsu, 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Miyagi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-3228","authenticated-orcid":false,"given":"Kensuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Organization for Promotion of Tenure Track, University of Miyazaki, 1-1 Gakuenkibanadai-nishi ,Miyazaki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Pet Clinic Hallelujah, 2544-1 Nakabaru ,Kasuya-machi, Kasuya County, Fukuoka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Kitade","sequence":"additional","affiliation":[{"name":"Kitade Animal Hospital, 2 Tajiri ,Ichishi-cho, Tsu, Mie,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Ibaragi","sequence":"additional","affiliation":[{"name":"Miyoshi Inter Animal Hospital, 27-103 Neura Fukuya-cho ,Miyoshi, Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Katagi","sequence":"additional","affiliation":[{"name":"Katagi Animal Hospital, 565-5 Matoba ,Kawagoe, Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Sawada","sequence":"additional","affiliation":[{"name":"Kitanomori Animal Hospital, 17-1-35 11-Jyou, Shin-kotoni ,Kita ward, Sapporo, Hokkaido,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yuki","sequence":"additional","affiliation":[{"name":"Yuki Animal Hospital, 2-99 Kiba-cho, Minato-ku ,Nagoya, Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Veterinary Internal Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino Department of Veterinary 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