{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:19:57Z","timestamp":1790738397219,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2712,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of California, Davis Center for Equine Health with funds provided by the State of California satellite wagering fund and contributions by private donors."},{"name":"University of California, Davis Center for Equine Health with funds provided by the State of California satellite wagering fund and contributions by private donors."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Equine herpesvirus-5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV-5 viral kinetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the effect of oral administration of valacyclovir on EHV-5 viral load measured by qPCR in blood, nasal secretions (NS) and BALF in horses with EMPF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six horses diagnosed with EMPF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective clinical trial was performed. Horses received 10 days of PO administered valacyclovir (loading dose 30 mg\/kg, maintenance dose 20 mg\/kg). Blood, NS, and BALF were collected for EHV-5 viral kinetics analyses during treatment. Blood and NS were collected every other day. BALF was collected on day 0 and day 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistical difference in median EHV-5 viral load between day 0 and day 10 for all samples tested. In blood median EHV-5 viral load was 7676 (range 575-39 781) on day 0 and 6822 (range 1136-18 635) glycoprotein B (gB) gene copies per million cells on day 10. For NS median EHV-5 viral load was 2.944 \u00d7 106 (range 184 691-3.394 \u00d7 109) on day 0 and 8.803 \u00d7 106 (range 251 186-9.868 \u00d7 108) gB gene copies per million cells on day 10. For BALF median EHV-5 viral load was 59,842 (range 61-315 655) on day 0 and 185 083 (range 3562-542 417) gB gene copies per million cells on day 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Valacyclovir might not be an effective short-term antiviral treatment but efficacy in treatment of EMPF is unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15230","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:23:57Z","timestamp":1537161837000},"page":"1763-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of valacyclovir on EHV-5 viral kinetics in horses with equine multinodular pulmonary fibrosis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-6982","authenticated-orcid":false,"given":"Charlotte A.","family":"Easton-Jones","sequence":"first","affiliation":[{"name":"Willian R Pritchard Veterinary Medical Teaching Hospital, University of California Davis , California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Madigan","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine and Epidemiology, , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Barnum","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine and Epidemiology, , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara K.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Center for Veterinary Health Sciences, Oklahoma State University Department of 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