{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:27:33Z","timestamp":1792092453921,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2712,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right ventricular (RV) enlargement and dysfunction are associated with prognosis in humans with pulmonary hypertension (PH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To assess RV size and systolic function in dogs with PH and to determine if they are associated with disease severity and right-sided congestive heart failure (R-CHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>89 dogs with PH and 74 healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study. PH was classified according to the tricuspid regurgitation pressure gradient. RV end-diastolic area (RVEDA) index was calculated as RVEDA divided by body surface area. RV systolic function was assessed with the tricuspid annular plane systolic excursion (TAPSE) and the RV fractional area change (FAC) normalized for body weight (TAPSEn and FACn, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RVEDA index was higher in dogs with moderate PH (10.8 cm2\/m2; range, 6.2-14.4 cm2\/m2) and severe PH (12.4 cm2\/m2; range, 7.7-21.4 cm2\/m2) than in those with mild PH (8.4 cm2\/m2; range, 4.8-11.6 cm2\/m2) and control dogs (8.5 cm2\/m2; range, 2.8-11.6 cm2\/m2; P &amp;lt; .001). RVEDA index was significantly higher in dogs with R-CHF (13.7 cm2\/m2; range, 11.0-21.4 cm2\/m2) than in dogs without R-CHF (9.4 cm2\/m2; range, 4.8-17.1 cm2\/m2; P &amp;lt; .001). The severity of tricuspid regurgitation (TR) was the only independent predictor of the RVEDA index (P &amp;lt; .001). TAPSEn and FACn were not significantly different among varying degrees of PH severity and between dogs with and without R-CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The RVEDA index can be used to evaluate RV size in dogs. It can provide additional information in dogs with PH and predict R-CHF. Severity of TR is the main determinant of RV enlargement in dogs with PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15253","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T03:48:49Z","timestamp":1537069729000},"page":"1541-1548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Echocardiographic evaluation of the right ventricular dimension and systolic function in dogs with pulmonary hypertension"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-6582","authenticated-orcid":false,"given":"Tommaso","family":"Vezzosi","sequence":"first","affiliation":[{"name":"University of Pisa Department of Veterinary Sciences, , Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Domenech","sequence":"additional","affiliation":[{"name":"Istituto Veterinario di Novara , Novara,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Pisa Department of Veterinary Sciences, , Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-5137","authenticated-orcid":false,"given":"Federica","family":"Marchesotti","sequence":"additional","affiliation":[{"name":"Istituto Veterinario di Novara , Novara,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Venco","sequence":"additional","affiliation":[{"name":"Veterinary Hospital Citt\u00e0 di Pavia , Pavia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-1297","authenticated-orcid":false,"given":"Eric","family":"Zini","sequence":"additional","affiliation":[{"name":"Istituto Veterinario di Novara , Novara,","place":["Italy"]},{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]},{"name":"Production and Health, University of Padova Department of Animal Medicine, , Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Josefa Fern\u00e1ndez","family":"del Palacio","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital , Department of Animal Medicine and Surgery, Murcia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Tognetti","sequence":"additional","affiliation":[{"name":"University of Pisa Department of Veterinary Sciences, , Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2026020922061198800_jvim15253-bib-0001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cvsm.2010.03.011","article-title":"Pulmonary hypertension in dogs: diagnosis and therapy","volume":"40","author":"Kellihan","year":"2010","journal-title":"Vet Clin North Am Small Anim Pract."},{"key":"2026020922061198800_jvim15253-bib-0002","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/CIRCULATIONAHA.104.517789","article-title":"Right atrial and ventricular adaptation to chronic right ventricular pressure overload","volume":"112","author":"Gaynor","year":"2005","journal-title":"Circulation."},{"key":"2026020922061198800_jvim15253-bib-0003","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"Vonk-Noordegraaf","year":"2013","journal-title":"J Am Coll Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0004","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"Ghio","year":"2001","journal-title":"J Am Coll Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0005","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","article-title":"Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension","volume":"28","author":"van Wolferen","year":"2007","journal-title":"Eur Heart J."},{"key":"2026020922061198800_jvim15253-bib-0006","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/ejechocard\/jeq011","article-title":"New echocardiographic prognostic factors for mortality in pulmonary arterial hypertension","volume":"11","author":"Brierre","year":"2010","journal-title":"Eur J Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0007","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.amjcard.2010.10.027","article-title":"Clinical and prognostic relevance of echocardiographic evaluation of right ventricular geometry in patients with idiopathic pulmonary arterial hypertension","volume":"107","author":"Ghio","year":"2011","journal-title":"Am J Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0008","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ahj.2013.02.027","article-title":"Prognostic significance of 2-dimensional, M-mode, and Doppler echo indices of right ventricular function in children with pulmonary arterial hypertension","volume":"165","author":"Kassem","year":"2013","journal-title":"Am Heart J."},{"key":"2026020922061198800_jvim15253-bib-0009","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1183\/16000617.0058-2015","article-title":"Imaging the heart in pulmonary hypertension: an update","volume":"24","author":"Gr\u00fcnig","year":"2015","journal-title":"Eur Respir Rev."},{"key":"2026020922061198800_jvim15253-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2012.10.009","article-title":"Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis","volume":"26","author":"Bossone","year":"2013","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0011","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American society of echocardiography endorsed by the European association of echocardiography, a registered branch of the European society of cardiology, and the Canadian society of echocardiography","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0012","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4137\/CMC.S27462","article-title":"Echocardiographic Assessment of the Right Ventricle, from the Conventional Approach to Speckle Tracking and Three-Dimensional Imaging, and Insights into the \u201cRight Way\u201d to Explore the Forgotten Chamber","volume":"9","author":"Kossaify","year":"2015","journal-title":"Clin Med Insights Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0013","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"2026020922061198800_jvim15253-bib-0014","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000371472","article-title":"Reference ranges for and determinants of right ventricular area in healthy adults by two-dimensional echocardiography","volume":"89","author":"Gr\u00fcnig","year":"2015","journal-title":"Respiration."},{"key":"2026020922061198800_jvim15253-bib-0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijcard.2015.05.105","article-title":"Change of right heart size and function by long-term therapy with riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension","volume":"195","author":"Marra","year":"2015","journal-title":"Int J Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0016","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jvc.2016.05.002","article-title":"Conventional echocardiographic assessment of the canine right heart: reference intervals and repeatability","volume":"18","author":"Gentile-Solomon","year":"2016","journal-title":"J Vet Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0017","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/jvim.15035","article-title":"Echocardiographic evaluation of the right atrial area index in dogs with pulmonary hypertension","volume":"32","author":"Vezzosi","year":"2018","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0018","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1540-8175.2007.00424.x","article-title":"Two-dimensional assessment of right ventricular function: an echocardiographic-MRI correlative study","volume":"24","author":"Anavekar","year":"2007","journal-title":"Echocardiography."},{"key":"2026020922061198800_jvim15253-bib-0019","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.cvsm.2017.04.004","article-title":"Right ventricular function: imaging techniques","volume":"47","author":"Visser","year":"2017","journal-title":"Vet Clin North Am Small Anim Pract."},{"key":"2026020922061198800_jvim15253-bib-0020","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1939-1676.2012.00981.x","article-title":"Tricuspid annular plane systolic excursion (TAPSE) in dogs: reference values and impact of pulmonary hypertension","volume":"26","author":"Pariaut","year":"2012","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0021","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/jvim.12564","article-title":"Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease","volume":"29","author":"Borgarelli","year":"2015","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0022","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/jvim.13609","article-title":"Diagnostic value of selected echocardiographic variables to identify pulmonary hypertension in dogs with myxomatous mitral valve disease","volume":"29","author":"Tidholm","year":"2015","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0023","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/jvim.13911","article-title":"Diagnostic value of right pulmonary artery distensibility index in dogs with pulmonary hypertension: comparison with doppler echocardiographic estimates of pulmonary arterial pressure","volume":"30","author":"Visser","year":"2016","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0024","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jvc.2017.03.007","article-title":"Tricuspid annular plane systolic excursion in dogs with myxomatous mitral valve disease with and without pulmonary hypertension","volume":"19","author":"Poser","year":"2017","journal-title":"J Vet Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.echo.2012.03.018","article-title":"Accuracy and interobserver concordance of echocardiographic assessment of right ventricular size and systolic function: a quality control exercise","volume":"25","author":"Ling","year":"2012","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0026","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jvc.2014.10.003","article-title":"Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: repeatability and reference intervals","volume":"17","author":"Visser","year":"2015","journal-title":"J Vet Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0027","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1939-1676.1999.tb01461.x","article-title":"Clinical characteristics of 53 dogs with Doppler-derived evidence of pulmonary hypertension: 1992-1996","volume":"13","author":"Johnson","year":"1999","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0028","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J."},{"key":"2026020922061198800_jvim15253-bib-0029","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jvc.2015.04.001","article-title":"Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol","volume":"17","author":"Visser","year":"2015","journal-title":"J Vet Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0030","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1086\/688712","article-title":"The effects of pulmonary vasodilating agents on right ventricular parameters in severe group 3 pulmonary hypertension: a pilot study","volume":"6","author":"Sato","year":"2016","journal-title":"Pulm Circ."},{"key":"2026020922061198800_jvim15253-bib-0031","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat","volume":"7","author":"Thomas","year":"1993","journal-title":"J Vet Intern Med."},{"key":"2026020922061198800_jvim15253-bib-0032","first-page":"163","article-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Chun","year":"2007","edition":"4"},{"key":"2026020922061198800_jvim15253-bib-0033","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ejechocard\/jeq031","article-title":"European association of echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease)","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur J Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0034","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.echo.2012.08.013","article-title":"Right heart assessment by echocardiography: gender and body size matters","volume":"25","author":"D'Oronzio","year":"2012","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0035","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.echo.2012.06.015","article-title":"Right ventricular normal measurements: time to index?","volume":"25","author":"Willis","year":"2012","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0036","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0735-1097(02)01744-8","article-title":"Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension","volume":"39","author":"Raymond","year":"2002","journal-title":"J Am Coll Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00019501-200502000-00003","article-title":"The right ventricle in pulmonary hypertension","volume":"16","author":"Chin","year":"2005","journal-title":"Coron Artery Dis."},{"key":"2026020922061198800_jvim15253-bib-0038","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0003-4975(92)91152-Y","article-title":"Production and reversibility of right ventricular hypertrophy and right heart failure in dogs","volume":"54","author":"Hsieh","year":"1992","journal-title":"Ann Thorac Surg."},{"key":"2026020922061198800_jvim15253-bib-0039","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0002-9149(03)00136-X","article-title":"Frequency and severity of tricuspid regurgitation determined by Doppler echocardiography in primary pulmonary hypertension","volume":"91","author":"Hinderliter","year":"2003","journal-title":"Am J Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1378\/chest.08-0277","article-title":"Functional tricuspid regurgitation in patients with pulmonary hypertension: is pulmonary artery pressure the only determinant of regurgitation severity?","volume":"135","author":"Mutlak","year":"2009","journal-title":"Chest."},{"key":"2026020922061198800_jvim15253-bib-0041","doi-asserted-by":"crossref","first-page":"e002714","DOI":"10.1161\/CIRCIMAGING.114.002714","article-title":"Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension","volume":"8","author":"Afilalo","year":"2015","journal-title":"Circ Cardiovasc Imaging."},{"key":"2026020922061198800_jvim15253-bib-0042","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1067\/mhj.2002.123575","article-title":"Prognostic significance of mitral regurgitation and tricuspid regurgitation in patients with left ventricular systolic dysfunction","volume":"144","author":"Koelling","year":"2002","journal-title":"Am Heart J."},{"key":"2026020922061198800_jvim15253-bib-0043","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jacc.2003.09.036","article-title":"Impact of tricuspid regurgitation on long-term survival","volume":"43","author":"Nath","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"2026020922061198800_jvim15253-bib-0044","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/echo.12912","article-title":"Impact of severe tricuspid regurgitation on accuracy of echocardiographic pulmonary artery systolic pressure estimation","volume":"32","author":"\u00d6zpelit","year":"2015","journal-title":"Echocardiography."},{"key":"2026020922061198800_jvim15253-bib-0045","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/echo.13555","article-title":"Impact of severe tricuspid regurgitation on accuracy of systolic pulmonary arterial pressure measured by Doppler echocardiography: analysis in an unselected patient population","volume":"34","author":"Fei","year":"2017","journal-title":"Echocardiography."},{"key":"2026020922061198800_jvim15253-bib-0046","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.echo.2006.01.014","article-title":"Severe tricuspid regurgitation shows significant impact in the relationship among peak systolic tricuspid annular velocity, tricuspid annular plane systolic excursion, and right ventricular ejection fraction","volume":"19","author":"Hsiao","year":"2006","journal-title":"J Am Soc Echocardiogr."},{"key":"2026020922061198800_jvim15253-bib-0047","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/jvim.14884","article-title":"Echocardiographic estimates of right ventricular systolic function in dogs with myxomatous mitral valve disease","volume":"32","author":"Chapel","year":"2018","journal-title":"J Vet Intern Med."}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.15253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/32\/5\/1541\/66670744\/jvim15253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/32\/5\/1541\/66670744\/jvim15253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:10:13Z","timestamp":1770693013000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/32\/5\/1541\/8449707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.15253","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,9,1]]},"assertion":[{"value":"2018-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}