{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:09:23Z","timestamp":1792879763952,"version":"4.5.0"},"reference-count":226,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":2658,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006952","name":"Board of Regents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007825","name":"American College of Veterinary Internal Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006952","name":"Louisiana Board of Regents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007825","name":"American College of Veterinary Internal Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive, and ultimately ulcerative lesions. This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type-2 receptor antagonists (H2RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not been well established in the dog and cat to date. Similar to the situation in human medicine, practice of inappropriate prescription of acid suppressants is also commonplace in veterinary medicine. This report challenges the dogma and clinical practice of administering GI protectants for the routine management of gastritis, pancreatitis, hepatic disease, and renal disease in dogs and cats lacking additional risk factors for ulceration or concerns for GI bleeding. Judicious use of acid suppressants is warranted considering recent studies that have documented adverse effects of long-term supplementation of PPIs in people and animals.<\/jats:p>","DOI":"10.1111\/jvim.15337","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T07:20:30Z","timestamp":1540970430000},"page":"1823-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-702X","authenticated-orcid":false,"given":"Stanley L.","family":"Marks","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California, Davis Department of Medicine & Epidemiology, , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3484","authenticated-orcid":false,"given":"Peter H.","family":"Kook","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-7898","authenticated-orcid":false,"given":"Mark G.","family":"Papich","sequence":"additional","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine Department of Molecular Biomedical Sciences, , Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-9530","authenticated-orcid":false,"given":"M. K.","family":"Tolbert","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Texas A & M University Department of Small Animal Clinical Sciences, , College Station, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Willard","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Texas A & M University Department of Small Animal Clinical Sciences, , College Station, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2026021006401382800_jvim15337-bib-0001","first-page":"1823","article-title":"Proton pump inhibitors: review of emerging concerns","volume":"32","author":"Nehra","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"2026021006401382800_jvim15337-bib-0002","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/pds.4043","article-title":"Proton pump inhibitor prescribing patterns in the UK: a primary care database study","volume":"25","author":"Othman","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2026021006401382800_jvim15337-bib-0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12328-011-0208-y","article-title":"Proton pump inhibitors: use, misuse and concerns about long-term therapy","volume":"4","author":"Rakesh","year":"2011","journal-title":"Clin J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0004","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12916-017-0804-x","article-title":"When is proton pump inhibitor use appropriate?","volume":"15","author":"Yadlapati","year":"2017","journal-title":"BMC Med"},{"key":"2026021006401382800_jvim15337-bib-0005","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/jvim.13932","article-title":"A prospective, placebo-controlled pilot evaluation of the effect of omeprazole on serum calcium, magnesium, cobalamin, gastrin concentrations, and bone in cats","volume":"30","author":"Gould","year":"2016","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0006","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bcpt.13023","article-title":"Side effects of long-term proton pump inhibitor use: a review","volume":"123","author":"Haastrup","year":"2018","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2026021006401382800_jvim15337-bib-0007","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/jvim.12461","article-title":"Wireless ambulatory esophageal pH monitoring in dogs with clinical signs interpreted as gastroesophageal reflux","volume":"28","author":"Kook","year":"2014","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0008","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1939-1676.2010.0651.x","article-title":"Efficacy of oral famotidine and 2 omeprazole formulations for the control of intragastric pH in dogs","volume":"25","author":"Tolbert","year":"2011","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/jvim.14615","article-title":"Repeated famotidine administration results in a diminished effect on intragastric pH in dogs","volume":"31","author":"Tolbert","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0010","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2460\/javma.250.5.530","article-title":"Continuous radiotelemetric monitoring of intragastric pH in a dog with peptic ulceration","volume":"250","author":"Lane","year":"2017","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0011","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/jps.23159","article-title":"Gastric pH and gastric residence time in fasted and fed conscious beagle dogs using the Bravo pH system","volume":"101","author":"Mahar","year":"2012","journal-title":"J Pharm Sci"},{"key":"2026021006401382800_jvim15337-bib-0012","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2460\/ajvr.1985.46.07.1516","article-title":"Radiotelemetric determination of gastrointestinal pH in four healthy beagles","volume":"46","author":"Youngberg","year":"1985","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0013","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1572-0241.2003.07398.x","article-title":"Ambulatory esophageal pH monitoring using a wireless system","volume":"98","author":"Pandolfino","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0014","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1136\/gut.2005.064691","article-title":"Acid reflux event detection using the Bravo wireless versus the Slimline catheter pH systems: why are the numbers so different?","volume":"54","author":"Pandolfino","year":"2005","journal-title":"Gut"},{"key":"2026021006401382800_jvim15337-bib-0015","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1136\/gutjnl-2014-307595","article-title":"The stomach in health and disease","volume":"64","author":"Hunt","year":"2015","journal-title":"Gut"},{"key":"2026021006401382800_jvim15337-bib-0016","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3109\/00365521.2015.1009157","article-title":"Upper gastrointestinal physiology and diseases","volume":"50","author":"Waldum","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0017","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3945\/ajcn.114.097394","article-title":"Is achlorhydria a cause of iron deficiency anemia?","volume":"102","author":"Betesh","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"2026021006401382800_jvim15337-bib-0018","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/jor.23221","article-title":"Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton","volume":"34","author":"Haffner-Luntzer","year":"2016","journal-title":"J Orthop Res"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0019","first-page":"105","article-title":"Neural control of the release and action of secretin","volume":"54","author":"Chey","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"2026021006401382800_jvim15337-bib-0020","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/00365510600873894","article-title":"Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouse","volume":"66","author":"Friis-Hansen","year":"2006","journal-title":"Scand J Clin Lab Invest"},{"key":"2026021006401382800_jvim15337-bib-0021","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1016353705970","article-title":"Comparison of canine and human gastrointestinal physiology","volume":"3","author":"Dressman","year":"1986","journal-title":"Pharm Res"},{"key":"2026021006401382800_jvim15337-bib-0022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/bdd.2510160502","article-title":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals","volume":"16","author":"Kararli","year":"1995","journal-title":"Biopharm Drug Dispos"},{"key":"2026021006401382800_jvim15337-bib-0023","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0016-5085(67)80097-0","article-title":"Comparison of gastric secretion in conscious dogs and cats","volume":"52","author":"Emas","year":"1967","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0024","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1002\/jps.21602","article-title":"Fed and fasted gastric pH and gastric residence time in conscious beagle dogs","volume":"98","author":"Sagawa","year":"2009","journal-title":"J Pharm Sci"},{"key":"2026021006401382800_jvim15337-bib-0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1098-2299(199606)38:2<73::AID-DDR1>3.0.CO;2-H","article-title":"Evaluation of gastrointestinal pH and gastric residence time via the Heidelberg radiotelemetry capsule: pharmaceutical application","volume":"38","author":"Mojaverian","year":"1996","journal-title":"Drug Dev Res"},{"key":"2026021006401382800_jvim15337-bib-0026","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/jvim.12493","article-title":"Evaluation of the effect of orally administered acid suppressants on intragastric pH in cats","volume":"29","author":"Parkinson","year":"2015","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0027","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/jvim.12580","article-title":"The effect of orally administered ranitidine and once-daily or twice-daily orally administered omeprazole on intragastric pH in cats","volume":"29","author":"Sutalo","year":"2015","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0028","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1046\/j.1365-2036.2001.01011.x","article-title":"Ambulatory gastric pH monitoring: proper probe placement and normal values","volume":"15","author":"Fackler","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0029","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2165\/00003495-199957060-00003","article-title":"Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use","volume":"57","author":"Maton","year":"1999","journal-title":"Drugs"},{"key":"2026021006401382800_jvim15337-bib-0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00045391-199506000-00007","article-title":"Comparative effects of liquid antacids on esophageal and gastric pH in patients with heartburn","volume":"2","author":"Decktor","year":"1995","journal-title":"Am J Ther"},{"key":"2026021006401382800_jvim15337-bib-0031","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00045391-199508000-00006","article-title":"Effects of aluminum\/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn","volume":"2","author":"Decktor","year":"1995","journal-title":"Am J Ther"},{"key":"2026021006401382800_jvim15337-bib-0032","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/apt.12318","article-title":"Post-prandial reflux suppression by a raft-forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH-impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double-blind study in reflux patients","volume":"37","author":"Sweis","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0033","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/apt.12857","article-title":"Gaviscon double action liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: a double-blind crossover study","volume":"40","author":"De Ruigh","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0034","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1939-1676.2008.0206.x","article-title":"Aluminum toxicity following administration of aluminum-based phosphate binders in 2 dogs with renal failure","volume":"22","author":"Segev","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0035","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.1440-1746.2003.03041.x","article-title":"Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection","volume":"18","author":"Komazawa","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0036","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1572-0241.2000.01701.x","article-title":"Twenty-four-hour intragastric pH: tolerance within 5 days of continuous ranitidine administration","volume":"95","author":"Lachman","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0037","author":"Tolbert"},{"key":"2026021006401382800_jvim15337-bib-0038","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/gut.40.1.36","article-title":"Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study","volume":"40","author":"Labenz","year":"1997","journal-title":"Gut"},{"key":"2026021006401382800_jvim15337-bib-0039","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1046\/j.1365-2036.1997.00257.x","article-title":"Review article: the pharmacological inhibition of gastric acid secretion--tolerance and rebound","volume":"11","author":"Sandvik","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2036.1990.tb00011.x","article-title":"Tolerance during 8 days of high-dose H2-blockade: placebo-controlled studies of 24-hour acidity and gastrin","volume":"4","author":"Smith","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0041","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2460\/ajvr.2005.66.425","article-title":"Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs","volume":"66","author":"Bersenas","year":"2005","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0042","first-page":"75","article-title":"Vomiting and diarrhea in a cat colony","volume":"34","author":"Diggs","year":"1995","journal-title":"Contemp Top Lab Anim Sci"},{"key":"2026021006401382800_jvim15337-bib-0043","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1939-1676.2007.tb03044.x","article-title":"Efficacy of famotidine for the prevention of exercise-induced gastritis in racing Alaskan sled dogs","volume":"21","author":"Williamson","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0044","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1939-1676.2009.0454.x","article-title":"Efficacy of omeprazole versus high-dose famotidine for prevention of exercise-induced gastritis in racing Alaskan sled dogs","volume":"24","author":"Williamson","year":"2010","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0045","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ajg.2011.474","article-title":"Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta-analysis","volume":"107","author":"Barkun","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0046","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/gast.1997.v112.pm9178669","article-title":"Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis","volume":"112","author":"Chiba","year":"1997","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0047","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/290159a0","article-title":"Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase","volume":"290","author":"Fellenius","year":"1981","journal-title":"Nature"},{"key":"2026021006401382800_jvim15337-bib-0048","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000028367","article-title":"Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles","volume":"60","author":"Kromer","year":"2000","journal-title":"Pharmacology"},{"key":"2026021006401382800_jvim15337-bib-0049","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1020905224001","article-title":"Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole","volume":"29","author":"Abelo","year":"2002","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"2026021006401382800_jvim15337-bib-0050","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/0016-5085(83)90442-0","article-title":"Inhibition of gastric acid secretion by omeprazole in the dog and rat","volume":"85","author":"Larsson","year":"1983","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0051","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1016\/S0021-9258(17)38778-1","article-title":"The relationship between gastric acid secretion and gastric H+,K+-ATPase activity","volume":"260","author":"Wallmark","year":"1985","journal-title":"J Biol Chem"},{"key":"2026021006401382800_jvim15337-bib-0052","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1046\/j.1365-2036.2001.01087.x","article-title":"Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole","volume":"15","author":"Andersson","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0053","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0016-5085(85)80133-5","article-title":"Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage","volume":"88","author":"Prichard","year":"1985","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0054","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3109\/03639049509026660","article-title":"Stability of omeprazole solutions at various pH values as determined by high-performance liquid chromatography","volume":"21","author":"Mathew","year":"1995","journal-title":"Drug Dev Ind Pharm"},{"key":"2026021006401382800_jvim15337-bib-0055","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2746\/042516403775696339","article-title":"Effect of GastroGard and three compounded oral omeprazole preparations on 24 h intragastric pH in gastrically cannulated mature horses","volume":"35","author":"Merritt","year":"2003","journal-title":"Equine Vet J"},{"key":"2026021006401382800_jvim15337-bib-0056","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2125.1990.tb03679.x","article-title":"Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects","volume":"29","author":"Andersson","year":"1990","journal-title":"Br J Clin Pharmacol"},{"key":"2026021006401382800_jvim15337-bib-0057","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1046\/j.1365-2036.2000.00829.x","article-title":"Proton pump inhibitors: better acid suppression when taken before a meal than without a meal","volume":"14","author":"Hatlebakk","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0058","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0016-5085(86)90565-2","article-title":"Influence of the stimulation state of the parietal cells on the inhibitory effect of omeprazole on gastric acid secretion in dogs","volume":"91","author":"De Graef","year":"1986","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0059","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1365-2036.2009.03979.x","article-title":"Clinical trial: the effect and timing of food on the pharmacokinetics and pharmacodynamics of dexlansoprazole MR, a novel dual delayed release formulation of a proton pump inhibitor--evidence for dosing flexibility","volume":"29","author":"Lee","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00498250110035615","article-title":"Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole","volume":"31","author":"Furuta","year":"2001","journal-title":"Xenobiotica"},{"key":"2026021006401382800_jvim15337-bib-0061","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00042737-200105000-00025","article-title":"Proton pump inhibitors and their drug interactions: an evidence-based approach","volume":"13","author":"Gerson","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0062","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.drudis.2009.03.014","article-title":"Proton pump inhibitors: actions and reactions","volume":"14","author":"Mullin","year":"2009","journal-title":"Drug Discov Today"},{"key":"2026021006401382800_jvim15337-bib-0063","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cvsm.2013.05.001","article-title":"Canine cytochrome P-450 pharmacogenetics","volume":"43","author":"Court","year":"2013","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026021006401382800_jvim15337-bib-0064","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3109\/03602532.2013.765445","article-title":"Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics","volume":"45","author":"Martinez","year":"2013","journal-title":"Drug Metab Rev"},{"key":"2026021006401382800_jvim15337-bib-0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0149-2918(00)80032-6","article-title":"The proton-pump inhibitors: similarities and differences","volume":"22","author":"Horn","year":"2000","journal-title":"Clin Ther"},{"key":"2026021006401382800_jvim15337-bib-0066","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1111\/j.1572-0241.2003.08783.x","article-title":"Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study","volume":"98","author":"Miner","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0067","doi-asserted-by":"crossref","first-page":"803","DOI":"10.5414\/CP202396","article-title":"Comparative effectiveness and tolerability of esomeprazole and omeprazole in gastro-esophageal reflux disease: a systematic review and meta-analysis","volume":"53","author":"Qi","year":"2015","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0068","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/jvim.14713","article-title":"Pharmacokinetics and acid suppressant efficacy of esomeprazole after intravenous, oral, and subcutaneous administration to healthy beagle dogs","volume":"31","author":"Hwang","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0069","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1939-1676.2012.00929.x","article-title":"The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs","volume":"26","author":"Zacuto","year":"2012","journal-title":"J Vet Intern Med"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000200917","article-title":"Appropriate acid suppression for the management of gastro-oesophageal reflux disease","volume":"51","author":"Bell","year":"1992","journal-title":"Digestion"},{"key":"2026021006401382800_jvim15337-bib-0071","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0016-5085(90)91015-X","article-title":"Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression","volume":"99","author":"Burget","year":"1990","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0072","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2460\/ajvr.1991.52.05.658","article-title":"Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs","volume":"52","author":"Jenkins","year":"1991","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0073","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/jvim.12555","article-title":"Efficacy of intravenous administration of combined acid suppressants in healthy dogs","volume":"29","author":"Tolbert","year":"2015","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0074","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11095-004-1185-3","article-title":"pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model","volume":"22","author":"Zhou","year":"2005","journal-title":"Pharm Res"},{"key":"2026021006401382800_jvim15337-bib-0075","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1345\/aph.1R071","article-title":"Evaluation of potential interactions between mycophenolic acid derivatives and proton pump inhibitors","volume":"46","author":"Gabardi","year":"2012","journal-title":"Ann Pharmacother"},{"key":"2026021006401382800_jvim15337-bib-0076","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ajg.2009.638","article-title":"Proton pump inhibitor and clopidogrel interaction: fact or fiction?","volume":"105","author":"Laine","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0077","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/clpt.2011.222","article-title":"Unveiling the mysteries of clopidogrel metabolism and efficacy","volume":"90","author":"Bonello","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0078","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJMoa0809171","article-title":"Cytochrome p-450 polymorphisms and response to clopidogrel","volume":"360","author":"Mega","year":"2009","journal-title":"N Engl J Med"},{"key":"2026021006401382800_jvim15337-bib-0079","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jvp.12340","article-title":"The effects of clopidogrel and omeprazole on platelet function in normal dogs","volume":"40","author":"Thames","year":"2017","journal-title":"J Vet Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0080","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1001\/jamainternmed.2015.7193","article-title":"Proton pump inhibitor use and the risk of chronic kidney disease","volume":"176","author":"Lazarus","year":"2016","journal-title":"JAMA Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0081","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2036.2007.03407.x","article-title":"Systematic review: proton pump inhibitor-associated acute interstitial nephritis","volume":"26","author":"Sierra","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0082","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1681\/ASN.2015121377","article-title":"Proton pump inhibitors and risk of incident CKD and progression to ESRD","volume":"27","author":"Xie","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2026021006401382800_jvim15337-bib-0083","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamaneurol.2015.4791","article-title":"Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis","volume":"73","author":"Gomm","year":"2016","journal-title":"JAMA Neurol"},{"key":"2026021006401382800_jvim15337-bib-0084","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1001\/jama.2013.280490","article-title":"Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency","volume":"310","author":"Lam","year":"2013","journal-title":"JAMA"},{"key":"2026021006401382800_jvim15337-bib-0085","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1001\/jama.296.24.2947","article-title":"Long-term proton pump inhibitor therapy and risk of hip fracture","volume":"296","author":"Yang","year":"2006","journal-title":"JAMA"},{"key":"2026021006401382800_jvim15337-bib-0086","doi-asserted-by":"crossref","first-page":"e0128004","DOI":"10.1371\/journal.pone.0128004","article-title":"Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis","volume":"10","author":"Lambert","year":"2015","journal-title":"PLoS One"},{"key":"2026021006401382800_jvim15337-bib-0087","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3109\/0886022X.2015.1057800","article-title":"Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies","volume":"37","author":"Cheungpasitporn","year":"2015","journal-title":"Ren Fail"},{"key":"2026021006401382800_jvim15337-bib-0088","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/cid\/civ432","article-title":"Use of acid suppression medication is associated with risk for C. difficile infection in infants and children: a population-based study","volume":"61","author":"Freedberg","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2026021006401382800_jvim15337-bib-0089","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1053\/j.gastro.2015.06.043","article-title":"Proton pump inhibitors alter specific taxa in the human gastrointestinal microbiome: a crossover trial","volume":"149","author":"Freedberg","year":"2015","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0090","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.4238\/2015.July.3.25","article-title":"Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis","volume":"14","author":"Xu","year":"2015","journal-title":"Genet Mol Res"},{"key":"2026021006401382800_jvim15337-bib-0091","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/0016-5085(93)90344-C","article-title":"Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis","volume":"104","author":"Lamberts","year":"1993","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0092","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cgh.2012.12.011","article-title":"Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis","volume":"11","author":"Lo","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0093","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1053\/j.gastro.2011.06.075","article-title":"Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis","volume":"141","author":"Wallace","year":"2011","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0094","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.mayocp.2014.07.015","article-title":"Nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and gastrointestinal injury: contrasting interactions in the stomach and small intestine","volume":"89","author":"Marlicz","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"2026021006401382800_jvim15337-bib-0095","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/vr.165.15.436","article-title":"Spontaneous gastroduodenal perforations in dogs: a retrospective study of 15 cases","volume":"165","author":"Cariou","year":"2009","journal-title":"Vet Rec"},{"key":"2026021006401382800_jvim15337-bib-0096","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1024\/0036-7281\/a000186","article-title":"Severe gastrointestinal bleeding secondary to lornoxicam in the dog","volume":"153","author":"Kook","year":"2011","journal-title":"Schweiz Arch Tierheilkd"},{"key":"2026021006401382800_jvim15337-bib-0097","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1939-1676.2003.tb02428.x","article-title":"Efficacy of omeprazole for the prevention of exercise-induced gastritis in racing Alaskan sled dogs","volume":"17","author":"Davis","year":"2003","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0098","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fvets.2018.00079","article-title":"Omeprazole minimally alters the fecal microbial community in six cats: a pilot study","volume":"5","author":"Schmid","year":"2018","journal-title":"Front Vet Sci"},{"key":"2026021006401382800_jvim15337-bib-0099","doi-asserted-by":"crossref","first-page":"118s","DOI":"10.1007\/BF01309396","article-title":"Misoprostol preclinical pharmacology","volume":"30","author":"Bauer","year":"1985","journal-title":"Dig Dis Sci"},{"key":"2026021006401382800_jvim15337-bib-0100","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0016-5085(19)32433-3","article-title":"An intestinal disease produced experimentally by a prostaglandin deficiency","volume":"69","author":"Robert","year":"1975","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0101","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2710.1991.tb00330.x","article-title":"Misoprostol\u2014a logical therapeutic approach to gastroduodenal mucosal injury induced by non-steroidal anti-inflammatory drugs?","volume":"16","author":"Fenn","year":"1991","journal-title":"J Clin Pharm Ther"},{"key":"2026021006401382800_jvim15337-bib-0102","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5326\/15473317-32-5-401","article-title":"The use of a synthetic prostaglandin E1 analog as a gastric protectant against aspirin-induced hemorrhage in the dog","volume":"32","author":"Bowersox","year":"1996","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026021006401382800_jvim15337-bib-0103","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1939-1676.1995.tb03269.x","article-title":"The effect of misoprostol on aspirin-induced gastroduodenal lesions in dogs","volume":"9","author":"Johnston","year":"1995","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0104","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1939-1676.2003.tb02449.x","article-title":"The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury","volume":"17","author":"Ward","year":"2003","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2460\/javma.1993.202.02.251","article-title":"Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs","volume":"202","author":"Murtaugh","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0106","first-page":"1463","article-title":"An endoscopic study comparing gastroprotection by prostaglandin E2, misoprostol and cimetidine against multiple doses of aspirin in dogs","volume":"90","author":"Holroyde","year":"1986","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0107","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s002689900079","article-title":"Protection of the gastroduodenal mucosa from the effects of diclofenac sodium: role of highly selective vagotomy and misoprostol","volume":"20","author":"Giannoukas","year":"1996","journal-title":"World J Surg"},{"key":"2026021006401382800_jvim15337-bib-0108","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1007\/s10620-013-2725-7","article-title":"The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats","volume":"58","author":"Satoh","year":"2013","journal-title":"Dig Dis Sci"},{"key":"2026021006401382800_jvim15337-bib-0109","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1939-1676.2000.tb01496.x","article-title":"Gastric mucosal lesions in dogs with acute intervertebral disc disease: characterization and effects of omeprazole or misoprostol","volume":"14","author":"Neiger","year":"2000","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0110","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2460\/ajvr.1999.60.08.982","article-title":"Efficacy of misoprostol in prevention of gastric hemorrhage in dogs treated with high doses of methylprednisolone sodium succinate","volume":"60","author":"Rohrer","year":"1999","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0111","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.2460\/ajvr.1997.58.11.1320","article-title":"Clinical evaluation of cimetidine, sucralfate, and misoprostol for prevention of gastrointestinal tract bleeding in dogs undergoing spinal surgery","volume":"58","author":"Hanson","year":"1997","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0112","first-page":"1310","article-title":"Stress ulceration prevention in live E. coli sepsis in cats","volume":"88","author":"Arvidsson","year":"1985","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0113","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/DHPS.S4334","article-title":"Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors","volume":"1","author":"Rostom","year":"2009","journal-title":"Drug Healthc Patient Saf"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0114","first-page":"S160","article-title":"Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects","volume":"99","author":"Tang","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"2026021006401382800_jvim15337-bib-0115","first-page":"117","article-title":"Mechanisms of action of sucralfate","volume":"3","author":"Nagashima","year":"1981","journal-title":"J Clin Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0116","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0016-5085(87)91026-2","article-title":"Mucosal protection by sucralfate and its components in acid-exposed rabbit esophagus","volume":"93","author":"Orlando","year":"1987","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0117","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/jvim.15076","article-title":"Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs","volume":"32","author":"Hill","year":"2018","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0118","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0016-5085(85)90128-3","article-title":"Sucralfate prevents experimental peptic esophagitis in rabbits","volume":"88","author":"Schweitzer","year":"1985","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0119","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0002-9343(87)90829-1","article-title":"Comparison of potential cytoprotective action of sucralfate and cimetidine. Studies with experimental feline esophagitis","volume":"83","author":"Clark","year":"1987","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0120","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0002-9343(87)90827-8","article-title":"Sucralfate versus alginate\/antacid in the treatment of peptic esophagitis","volume":"83","author":"Evreux","year":"1987","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0121","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/00365528509089662","article-title":"Sucralfate and alginate\/antacid in reflux esophagitis","volume":"20","author":"Laitinen","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0122","doi-asserted-by":"crossref","first-page":"119s","DOI":"10.1016\/0002-9343(91)90462-7","article-title":"Reflux esophagitis therapy: sucralfate versus ranitidine in a double blind multicenter trial","volume":"91","author":"Bremner","year":"1991","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0123","doi-asserted-by":"crossref","first-page":"107s","DOI":"10.1016\/0002-9343(91)90460-F","article-title":"Healing of erosive esophagitis with sucralfate and cimetidine: influence of pretreatment lower esophageal sphincter pressure and serum pepsinogen I levels","volume":"91","author":"Ros","year":"1991","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0124","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0002-9343(87)90826-6","article-title":"Comparison of the effect of sucralfate and ranitidine in reflux esophagitis","volume":"83","author":"Simon","year":"1987","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0002-9343(87)90825-4","article-title":"Clinical efficacy of sucralfate in reflux esophagitis. Comparison with cimetidine","volume":"83","author":"Tytgat","year":"1987","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0126","first-page":"231","article-title":"The protective effects of sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone","volume":"53","author":"Geor","year":"1989","journal-title":"Can J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0127","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3109\/00365528809090178","article-title":"Sucralfate versus placebo in reflux esophagitis. A double-blind multicenter study","volume":"23","author":"Carling","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0128","first-page":"1143","article-title":"Detection of esophageal ulcerations with technetium-99m albumin sucralfate","volume":"27","author":"Goff","year":"1986","journal-title":"J Nucl Med"},{"key":"2026021006401382800_jvim15337-bib-0129","doi-asserted-by":"crossref","first-page":"123s","DOI":"10.1016\/0002-9343(91)90463-8","article-title":"Sucralfate therapy and reflux esophagitis: an overview","volume":"91","author":"Orlando","year":"1991","journal-title":"Am J Med"},{"key":"2026021006401382800_jvim15337-bib-0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4318\/tjg.2010.0040","article-title":"The efficiency of sucralfate in corrosive esophagitis: a randomized, prospective study","volume":"21","author":"Gumurdulu","year":"2010","journal-title":"Turk J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0131","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00405-014-3023-5","article-title":"Efficacy of sucralfate for the treatment of post-tonsillectomy symptoms","volume":"272","author":"Siupsinskiene","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2026021006401382800_jvim15337-bib-0132","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/bmj.286.6375.1379","article-title":"Aluminium hydroxide versus sucralfate as a phosphate binder in uraemia","volume":"286","author":"Leung","year":"1983","journal-title":"Br Med J (Clin Res Ed)"},{"key":"2026021006401382800_jvim15337-bib-0133","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7326\/0003-4819-111-2-179","article-title":"Sucralfate, intestinal aluminum absorption, and aluminum toxicity in a patient on dialysis","volume":"111","author":"Robertson","year":"1989","journal-title":"Ann Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0134","first-page":"181","article-title":"Sucralfate: a review of drug tolerance and safety","volume":"3","author":"Fisher","year":"1981","journal-title":"J Clin Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0135","first-page":"169","article-title":"Safety experience with sucralfate in Japan","volume":"3","author":"Ishimori","year":"1981","journal-title":"J Clin Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0136","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1128\/AAC.34.5.931","article-title":"Sucralfate significantly reduces ciprofloxacin concentrations in serum","volume":"34","author":"Garrelts","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2026021006401382800_jvim15337-bib-0137","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/j.1875-9114.1989.tb04152.x","article-title":"The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin","volume":"9","author":"Nix","year":"1989","journal-title":"Pharmacotherapy"},{"key":"2026021006401382800_jvim15337-bib-0138","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/jama.1989.03430070049022","article-title":"Ciprofloxacin levels when receiving sucralfate","volume":"262","author":"Yuk","year":"1989","journal-title":"JAMA"},{"key":"2026021006401382800_jvim15337-bib-0139","first-page":"58","article-title":"Effect of sucralfate on theophylline absorption in healthy volunteers","volume":"7","author":"Cantral","year":"1988","journal-title":"Clin Pharm"},{"key":"2026021006401382800_jvim15337-bib-0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/jvp.12165","article-title":"The effect of sucralfate tablets vs. suspension on oral doxycycline absorption in dogs","volume":"38","author":"KuKanich","year":"2015","journal-title":"J Vet Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0141","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/jvp.12116","article-title":"Effect of sucralfate on oral minocycline absorption in healthy dogs","volume":"37","author":"KuKanich","year":"2014","journal-title":"J Vet Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0142","first-page":"607","article-title":"Effect of sucralfate on phenytoin bioavailability","volume":"20","author":"Hall","year":"1986","journal-title":"Drug Intell Clin Pharm"},{"key":"2026021006401382800_jvim15337-bib-0143","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/106002809102500710","article-title":"Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration","volume":"25","author":"Rey","year":"1991","journal-title":"DICP"},{"key":"2026021006401382800_jvim15337-bib-0144","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/jvim.13796","article-title":"Effect of sucralfate on the relative bioavailability of enrofloxacin and ciprofloxacin in healthy fed dogs","volume":"30","author":"KuKanich","year":"2016","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0145","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0016-5085(00)70004-7","article-title":"Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome","volume":"118","author":"Wolfe","year":"2000","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0146","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/BF01798367","article-title":"The treatment of gastric ulcer with antisecretory drugs. Relationship of pharmacological effect to healing rates","volume":"33","author":"Howden","year":"1988","journal-title":"Dig Dis Sci"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0147","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1523-5378.2007.00576.x","article-title":"Evolution of Helicobacter pylori therapy from a meta-analytical perspective","volume":"12","author":"Gisbert","year":"2007","journal-title":"Helicobacter"},{"issue":"6","key":"2026021006401382800_jvim15337-bib-0148","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.1995.tb00777.x","article-title":"The relationship between the control of pH and healing and symptom relief in gastro-oesophageal reflux disease","volume":"9","author":"Hunt","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0149","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1365-2982.2012.01888.x","article-title":"PPI therapy is equally effective in well-defined non-erosive reflux disease and in reflux esophagitis: a meta-analysis","volume":"24","author":"Weijenborg","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"2026021006401382800_jvim15337-bib-0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-230X-2-17","article-title":"Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials","volume":"2","author":"Salas","year":"2002","journal-title":"BMC Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0151","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cgh.2006.09.012","article-title":"Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials","volume":"5","author":"Wang","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0152","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yasu.2013.02.004","article-title":"Current management of the Zollinger-Ellison syndrome","volume":"47","author":"Krampitz","year":"2013","journal-title":"Adv Surg"},{"key":"2026021006401382800_jvim15337-bib-0153","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.cgh.2013.05.034","article-title":"Co-prescription of gastroprotective agents and their efficacy in elderly patients taking nonsteroidal anti-inflammatory drugs: a systematic review of observational studies","volume":"11","author":"Medlock","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0154","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1939-1676.1989.tb00863.x","article-title":"Gastroduodenal ulceration in dogs. Retrospective study of 43 cases and literature review","volume":"3","author":"Stanton","year":"1989","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0155","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5326\/0380176","article-title":"Spontaneous gastroduodenal perforation in 16 dogs and seven cats (1982-1999)","volume":"38","author":"Hinton","year":"2002","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026021006401382800_jvim15337-bib-0156","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/jfms.2001.0148","article-title":"Gastroduodenal ulceration in cats: eight cases and a review of the literature","volume":"4","author":"Liptak","year":"2002","journal-title":"J Feline Med Surg"},{"key":"2026021006401382800_jvim15337-bib-0157","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1939-1676.2007.tb01936.x","article-title":"Triple antimicrobial therapy and acid suppression in dogs with chronic vomiting and gastric Helicobacter spp","volume":"21","author":"Leib","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0158","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/apt.13007","article-title":"Helicobacter-negative gastritis: a distinct entity unrelated to Helicobacter pylori infection","volume":"41","author":"Genta","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0159","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/vr.91.19.441","article-title":"Peptic ulceration in the dog: a clinico-pathological study","volume":"91","author":"Murray","year":"1972","journal-title":"Vet Rec"},{"key":"2026021006401382800_jvim15337-bib-0160","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4254\/wjh.v8.i4.231","article-title":"Portal hypertensive gastropathy: a systematic review of the pathophysiology, clinical presentation, natural history and therapy","volume":"8","author":"Gjeorgjievski","year":"2016","journal-title":"World J Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0161","first-page":"29","article-title":"Influence of liver upon canine gastric secretion","volume":"54","author":"Silen","year":"1963","journal-title":"Surgery"},{"key":"2026021006401382800_jvim15337-bib-0162","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/vr.100627","article-title":"Serum gastrin concentrations in dogs with liver disorders","volume":"171","author":"Mazaki-Tovi","year":"2012","journal-title":"Vet Rec"},{"key":"2026021006401382800_jvim15337-bib-0163","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1046\/j.1440-1746.2002.02775.x","article-title":"Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study","volume":"17","author":"Zhou","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0164","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2460\/javma.244.1.78","article-title":"Endovascular evaluation and treatment of intrahepatic portosystemic shunts in dogs: 100 cases (2001-2011)","volume":"244","author":"Weisse","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0165","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1097\/CCM.0b013e3181f17adf","article-title":"Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis","volume":"38","author":"Marik","year":"2010","journal-title":"Crit Care Med"},{"key":"2026021006401382800_jvim15337-bib-0166","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/CCM.0b013e3182758734","article-title":"Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis","volume":"41","author":"Alhazzani","year":"2013","journal-title":"Crit Care Med"},{"key":"2026021006401382800_jvim15337-bib-0167","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1476-4431.2011.00680.x","article-title":"A review of stress-related mucosal disease","volume":"21","author":"Monnig","year":"2011","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026021006401382800_jvim15337-bib-0168","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/vec.12434","article-title":"Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom","volume":"26","author":"Swann","year":"2016","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"2026021006401382800_jvim15337-bib-0169","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1939-1676.2006.tb01794.x","article-title":"Temporal relationship between gastrointestinal protein loss, gastric ulceration or erosion, and strenuous exercise in racing Alaskan sled dogs","volume":"20","author":"Davis","year":"2006","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3920\/CEP14002","article-title":"Effect of simulated deployment patrols on gastric mucosa of explosive detection dogs","volume":"10","author":"Davis","year":"2014","journal-title":"Comp Exercise Physiol"},{"key":"2026021006401382800_jvim15337-bib-0171","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2460\/ajvr.70.6.787","article-title":"Effect of gastric ulceration on physiologic responses to exercise in horses","volume":"70","author":"Nieto","year":"2009","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0172","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4292\/wjgpt.v6.i4.127","article-title":"Helicobacter pylori: effect of coexisting diseases and update on treatment regimens","volume":"6","author":"Chang","year":"2015","journal-title":"World J Gastroint Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0173","first-page":"2329","article-title":"Upper gastrointestinal bleeding in patients with chronic renal failure: role of vascular ectasia","volume":"91","author":"Chalasani","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0174","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0022-4804(75)90005-0","article-title":"Gastrin levels and gastric acid secretion in anephric patients and in patients with chronic and acute renal failure","volume":"18","author":"Falcao","year":"1975","journal-title":"J Surg Res"},{"key":"2026021006401382800_jvim15337-bib-0175","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/sdi.12301","article-title":"Evidence-based review of gastrointestinal bleeding in the chronic kidney disease patient","volume":"28","author":"Kalman","year":"2015","journal-title":"Semin Dial"},{"key":"2026021006401382800_jvim15337-bib-0176","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0091270002239700","article-title":"Famotidine disposition in children and adolescents with chronic renal insufficiency","volume":"43","author":"Maples","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"2026021006401382800_jvim15337-bib-0177","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2460\/javma.233.5.729","article-title":"Clinicopathologic, histologic, and toxicologic findings in 70 cats inadvertently exposed to pet food contaminated with melamine and cyanuric acid","volume":"233","author":"Cianciolo","year":"2008","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0178","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2460\/javma.1998.213.06.826","article-title":"Gastrin concentrations in plasma of cats with chronic renal failure","volume":"213","author":"Goldstein","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0179","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jvim.12342","article-title":"Relationship among serum creatinine, serum gastrin, calcium-phosphorus product, and uremic gastropathy in cats with chronic kidney disease","volume":"28","author":"McLeland","year":"2014","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1939-1676.2005.tb02700.x","article-title":"Histopathologic features of canine uremic gastropathy: a retrospective study","volume":"19","author":"Peters","year":"2005","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0181","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/jvim.14807","article-title":"Evaluation of gastric pH and serum gastrin concentrations in cats with chronic kidney disease","volume":"31","author":"Tolbert","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0182","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/1098612X14563097","article-title":"Survey of dietary and medication practices of owners of cats with chronic kidney disease","volume":"17","author":"Markovich","year":"2015","journal-title":"J Feline Med Surg"},{"key":"2026021006401382800_jvim15337-bib-0183","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.maturitas.2014.05.019","article-title":"Use of proton pump inhibitors (PPI) and history of earlier fracture are independent risk factors for fracture in postmenopausal women. The WHILA study","volume":"78","author":"Moberg","year":"2014","journal-title":"Maturitas"},{"key":"2026021006401382800_jvim15337-bib-0184","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1748-5827.1998.tb03613.x","article-title":"Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995","volume":"39","author":"Barber","year":"1998","journal-title":"J Small Anim Pract"},{"key":"2026021006401382800_jvim15337-bib-0185","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2460\/javma.241.10.1326","article-title":"Parathyroid hormone concentration in geriatric cats with various degrees of renal function","volume":"241","author":"Finch","year":"2012","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0186","doi-asserted-by":"crossref","first-page":"e110057","DOI":"10.1371\/journal.pone.0110057","article-title":"The effect of naturally occurring chronic kidney disease on the micro-structural and mechanical properties of bone","volume":"9","author":"Shipov","year":"2014","journal-title":"PLoS One"},{"key":"2026021006401382800_jvim15337-bib-0187","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/vcp.12461","article-title":"Occult gastrointestinal bleeding is a common finding in dogs with chronic kidney disease","volume":"46","author":"Crivellenti","year":"2017","journal-title":"Vet Clin Pathol"},{"key":"2026021006401382800_jvim15337-bib-0188","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/1751-2980.12206","article-title":"Prevalence and risk factors for clinically significant upper gastrointestinal bleeding in patients with severe acute pancreatitis","volume":"16","author":"Zhan","year":"2015","journal-title":"J Dig Dis"},{"key":"2026021006401382800_jvim15337-bib-0189","first-page":"463","article-title":"Temporary elevation of pancreatic lysosomal enzymes, as a result of the omeprazole-induced peripancreatic inflammation in male Wistar rats","volume":"51","author":"Burdan","year":"2000","journal-title":"J Physiol Pharmacol"},{"key":"2026021006401382800_jvim15337-bib-0190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11626-006-9004-2","article-title":"Effect of proton pump inhibitor on amylase release from isolated pancreatic acini","volume":"43","author":"Cai","year":"2007","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"2026021006401382800_jvim15337-bib-0191","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.lfs.2010.09.008","article-title":"Effects of pantoprazole in experimental acute pancreatitis","volume":"87","author":"Hackert","year":"2010","journal-title":"Life Sci"},{"key":"2026021006401382800_jvim15337-bib-0192","doi-asserted-by":"crossref","first-page":"362","DOI":"10.4166\/kjg.2012.60.6.362","article-title":"Effect of proton pump inhibitor in patients with acute pancreatitis\u2014pilot study","volume":"60","author":"Yoo","year":"2012","journal-title":"Korean J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0193","first-page":"55","article-title":"Benign esophageal stricture in the dog and cat: a retrospective study of 20 cases","volume":"66","author":"Adamama-Moraitou","year":"2002","journal-title":"Can J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0194","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5326\/0400455","article-title":"Postanesthetic esophageal dysfunction in 13 dogs","volume":"40","author":"Wilson","year":"2004","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026021006401382800_jvim15337-bib-0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-2999(96)00093-3","article-title":"Non-adrenergic non-cholinergic neuron stimulation in the cat lower esophageal sphincter","volume":"304","author":"Kortezova","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"2026021006401382800_jvim15337-bib-0196","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2460\/ajvr.1985.46.04.963","article-title":"Effects of atropine, acepromazine, meperidine, and xylazine on gastroesophageal sphincter pressure in the dog","volume":"46","author":"Strombeck","year":"1985","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0197","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2460\/ajvr.67.11.1821","article-title":"Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs","volume":"67","author":"Wilson","year":"2006","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0198","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2460\/ajvr.2005.66.386","article-title":"Effects of preanesthetic administration of morphine on gastroesophageal reflux and regurgitation during anesthesia in dogs","volume":"66","author":"Wilson","year":"2005","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0199","first-page":"G551","article-title":"Diaphragmatic contribution to gastroesophageal competence and reflux in dogs","volume":"263","author":"Martin","year":"1992","journal-title":"Am J Physiol"},{"key":"2026021006401382800_jvim15337-bib-0200","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0002-9610(05)81193-6","article-title":"Concentration of refluxed acid and esophageal mucosal injury","volume":"164","author":"Bremner","year":"1992","journal-title":"Am J Surg"},{"key":"2026021006401382800_jvim15337-bib-0201","first-page":"133","article-title":"Pepsin and the esophagus","volume":"72","author":"Hirschowitz","year":"1999","journal-title":"Yale J Biol Med"},{"key":"2026021006401382800_jvim15337-bib-0202","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jvim.14704","article-title":"Prevalence of gastroesophageal reflux in cats during anesthesia and effect of omeprazole on gastric pH","volume":"31","author":"Garcia","year":"2017","journal-title":"J Vet Intern Med"},{"key":"2026021006401382800_jvim15337-bib-0203","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2460\/ajvr.75.4.361","article-title":"High-resolution manometric evaluation of the effects of cisapride and metoclopramide hydrochloride administered orally on lower esophageal sphincter pressure in awake dogs","volume":"75","author":"Kempf","year":"2014","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0204","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2460\/ajvr.77.8.818","article-title":"High-resolution manometric evaluation of the effects of cisapride on the esophagus during administration of solid and liquid boluses in awake healthy dogs","volume":"77","author":"Ullal","year":"2016","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0205","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2460\/ajvr.67.1.26","article-title":"Influence of metoclopramide on gastroesophageal reflux in anesthetized dogs","volume":"67","author":"Wilson","year":"2006","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2036.1995.tb00347.x","article-title":"A comparison of lansoprazole and ranitidine in the treatment of erosive oesophagitis. Multicentre Investigational Group","volume":"9","author":"Robinson","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0207","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF01798351","article-title":"Omeprazole (40 mg) is superior to ranitidine in short-term treatment of ulcerative reflux esophagitis","volume":"33","author":"Vantrappen","year":"1988","journal-title":"Dig Dis Sci"},{"key":"2026021006401382800_jvim15337-bib-0208","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2036.2003.01756.x","article-title":"Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease","volume":"18","author":"Vakil","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"2026021006401382800_jvim15337-bib-0209","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s10620-015-3712-y","article-title":"Challenges to the treatment and new perspectives for the eradication of Helicobacter pylori","volume":"60","author":"Yazbek","year":"2015","journal-title":"Dig Dis Sci"},{"key":"2026021006401382800_jvim15337-bib-0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3748\/wjg.v21.i1.139","article-title":"Pharmacological therapy used in the elimination of Helicobacter pylori infection: a review","volume":"21","author":"Dos Santos","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2026021006401382800_jvim15337-bib-0211","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1440-1746.2000.02055.x","article-title":"Effect of intragastric pH on control of peptic ulcer bleeding","volume":"15","author":"Li","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"2026021006401382800_jvim15337-bib-0212","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.gie.2009.03.003","article-title":"Isolated gastric mucosal hemorrhages in idiopathic thrombocytopenic purpura","volume":"70","author":"Dang","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"2026021006401382800_jvim15337-bib-0213","first-page":"805","article-title":"Therapeutic possibilities in the management of gastrointestinal bleeding in thrombocytopenic patients","volume":"135","author":"Gurzo","year":"1994","journal-title":"Orv Hetil"},{"key":"2026021006401382800_jvim15337-bib-0214","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1097\/MPH.0000000000000292","article-title":"Severe hemorrhage in Chinese children with immune thrombocytopenia","volume":"37","author":"Zhou","year":"2015","journal-title":"J Pediatr Hematol Oncol"},{"key":"2026021006401382800_jvim15337-bib-0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.5326\/0390523","article-title":"Packed red blood cell transfusions in dogs with gastrointestinal hemorrhage: 55 cases (1999-2001)","volume":"39","author":"Waldrop","year":"2003","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026021006401382800_jvim15337-bib-0216","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0016-5085(78)90352-9","article-title":"Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage","volume":"74","author":"Green","year":"1978","journal-title":"Gastroenterology"},{"key":"2026021006401382800_jvim15337-bib-0217","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/gut.30.12.1704","article-title":"Clot lysis by gastric juice: an in vitro study","volume":"30","author":"Patchett","year":"1989","journal-title":"Gut"},{"key":"2026021006401382800_jvim15337-bib-0218","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1476-4431.2001.tb00076.x","article-title":"Complications of methylprednisolone sodium succinate therapy in Dachshunds with surgically treated intervertebral disc disease","volume":"11","author":"Boag","year":"2001","journal-title":"J Vet Emerg Crit Care"},{"key":"2026021006401382800_jvim15337-bib-0219","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5326\/15473317-34-2-129","article-title":"Complications associated with high-dose prednisolone sodium succinate therapy in dogs with neurological injury","volume":"34","author":"Culbert","year":"1998","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026021006401382800_jvim15337-bib-0220","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2460\/javma.1982.180.12.1443","article-title":"Gastrointestinal hemorrhage and pancreatitis associated with intervertebral disk diseases in the dog","volume":"180","author":"Moore","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0221","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2460\/javma.1986.188.02.145","article-title":"Colonic perforation in corticosteroid-treated dogs","volume":"188","author":"Toombs","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"2026021006401382800_jvim15337-bib-0222","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2460\/ajvr.1983.44.07.1233","article-title":"Effects of dexamethasone and surgical hypotension on the stomach of dogs: clinical, endoscopic, and pathologic evaluations","volume":"44","author":"Sorjonen","year":"1983","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0223","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2460\/ajvr.1999.60.08.977","article-title":"Gastric hemorrhage in dogs given high doses of methylprednisolone sodium succinate","volume":"60","author":"Rohrer","year":"1999","journal-title":"Am J Vet Res"},{"key":"2026021006401382800_jvim15337-bib-0224","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1007\/s10620-015-3642-8","article-title":"The inappropriate prescription of oral proton pump inhibitors in the hospital setting: a prospective cross-sectional study","volume":"60","author":"Kelly","year":"2015","journal-title":"Dig Dis Sci"},{"key":"2026021006401382800_jvim15337-bib-0225","doi-asserted-by":"crossref","first-page":"d56060","DOI":"10.1371\/journal.pone.0056060","article-title":"Proton pump inhibitor use in the U.S. ambulatory setting, 2002-2009","volume":"8","author":"Rotman","year":"2013","journal-title":"PLoS One"},{"key":"2026021006401382800_jvim15337-bib-0226","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jhm.1901","article-title":"Inappropriate prescribing of proton pump inhibitors in hospitalized patients","volume":"7","author":"Reid","year":"2012","journal-title":"J Hosp Med"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.15337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/32\/6\/1823\/66838741\/jvim15337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/32\/6\/1823\/66838741\/jvim15337.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:40:45Z","timestamp":1770723645000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/32\/6\/1823\/8471031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":226,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.15337","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,11,1]]},"assertion":[{"value":"2018-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}