{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:41:45Z","timestamp":1783762905748,"version":"3.55.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2531,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"IDEXX Laboratories, Inc"},{"name":"NC State-CVM Bartonella\/Vector Borne Disease Foundation research fund"},{"name":"IDEXX Laboratories, Inc"},{"name":"NC State-CVM Bartonella\/Vector Borne Disease Foundation research fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ehrlichia ewingii is the most seroprevalent Ehrlichia-infecting dogs in the southern and mid-western United States. Fever, lameness, and polyarthritis are commonly reported findings in dogs naturally infected with E. ewingii.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate clinicopathologic findings in a population of dogs naturally infected with E. ewingii.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-one dogs PCR positive for E. ewingii and PCR negative for other targeted vector-borne organisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Clinical and clinicopathologic data including physical examination findings, CBC, serum biochemistry, urinalysis (UA), symmetric dimethylarginine (SDMA), and vector-borne disease diagnostic results were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Frequent clinical diagnoses other than ehrlichiosis (28\/41; 68.3%) were renal disease (7\/41; 17.1%) and immune-mediated hemolytic anemia (IMHA) (6\/41; 14.6%). The most frequent physical examination finding was joint pain (14\/41; 34.1%). Prominent hematologic and biochemical abnormalities included abnormal lymphocyte counts (22\/36; 61.1%); neutrophilia (21\/37; 56.8%); increased alkaline phosphatase (20\/35; 57.1%) and alanine transaminase (14\/35; 40%) activities; and increased SDMA concentration (11\/34; 32.4%). Urinalysis abnormalities included proteinuria (20\/27; 74%), most with inactive sediments (16\/20; 80%). Dogs were seroreactive by Ehrlichia canis immunofluorescence assay (IFA; 17\/39; 43.6%) and Ehrlichia ELISA (34\/41; 82.9%). Seroreactivity by IFA for other vector-borne pathogens included Bartonella (1\/39; 2.6%), Rickettsia rickettsii (spotted-fever group rickettsiae) (12\/39; 30.8%), and Borrelia burgdorferi by ELISA (1\/41; 2.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Renal disease, IMHA, proteinuria, neutrophilia, abnormal lymphocytes, and increased liver enzyme activities were common in this group of E. ewingii-infected dogs. Studies are needed to determine if E. ewingii contributes to comorbidities or is a precipitating factor in clinical syndromes in persistently infected dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15354","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T02:49:37Z","timestamp":1546483777000},"page":"618-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinicopathological findings in 41 dogs (2008-2018) naturally infected with\n                    <i>Ehrlichia ewingii<\/i>"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-2511","authenticated-orcid":false,"given":"Barbara A.","family":"Qurollo","sequence":"first","affiliation":[{"name":"Vector Borne Disease Diagnostic Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University ,Raleigh,North 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