{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:35:05Z","timestamp":1790217305714,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2590,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","award":["2016 Advancement in Equine Research Award"],"award-info":[{"award-number":["2016 Advancement in Equine Research Award"]}],"id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010282","name":"Harry M. Zweig Memorial Fund for Equine Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2016-67015-24765"],"award-info":[{"award-number":["2016-67015-24765"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Niarchos Family"},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","award":["2016 Advancement in Equine Research Award"],"award-info":[{"award-number":["2016 Advancement in Equine Research Award"]}],"id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010282","name":"Harry M. Zweig Memorial Fund for\u00a0Equine\u00a0Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2016\u201067015\u201024765"],"award-info":[{"award-number":["2016\u201067015\u201024765"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A novel equine parvovirus (EqPV-H) was recently discovered in the equine liver with Theiler's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of EqPV-H infection in naturally occurring Theiler's disease cases and in-contact horses in the absence of historical equine biologic product administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten cases of Theiler's disease from 6 separate properties were included in the study, based on the criteria of acute onset of clinical signs of liver failure with laboratory or histopathologic findings characteristic of Theiler's disease and no history of receiving an equine biologic product within the preceding 4\u2009months. In addition, 37 in-contact horses from 4 of the 6 properties were screened for EqPV-H infection and hepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In prospective case series, cases were diagnosed with Theiler's disease by the attending veterinarian and were tested for EqPV-H by PCR of liver or serum. In-contact horses were assessed via serum chemistry and PCR at the attending veterinarian's discretion. Hepatitis was defined as serum gamma-glutamyltransferase activity above reference interval. The association of EqPV-H with hepatitis was determined by Fisher's exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine of 10 (90%) Theiler's disease cases and 54% of tested in-contact horses were EqPV-H positive. Hepatitis was significantly associated with EqPV-H infection (P\u2009=\u2009.036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Although further study is required to identify EqPV-H as the causative agent of Theiler's disease, EqPV-H appears strongly associated with cases of fatal Theiler's disease and subclinical hepatitis in horses in contact with those cases. The prevalence of EqPV-H infection on affected properties can be high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15362","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T03:24:00Z","timestamp":1544066640000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Viral testing of 10 cases of Theiler's disease and 37 in-contact horses in the absence of equine biologic product administration: A prospective study (2014-2018)"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-3967","authenticated-orcid":false,"given":"Joy E.","family":"Tomlinson","sequence":"first","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University Department of Microbiology and Immunology, , Ithaca, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bud 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Canton,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Jamieson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Oklahoma State University Department of Clinical Sciences, , Stillwater, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane V.","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"Carlson College of Veterinary Medicine, Oregon State University Department of Biomedical Sciences, , Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bildfell","sequence":"additional","affiliation":[{"name":"Carlson College of Veterinary Medicine, Oregon State University Department of Biomedical Sciences, , Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica C.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Carlson College of Veterinary Medicine, Oregon State University Department of Clinical Sciences, , Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Laverack","sequence":"additional","affiliation":[{"name":"New York State Animal Health Diagnostic Center, Cornell University , Ithaca, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall W.","family":"Renshaw","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Dubovi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell 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