{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:26:53Z","timestamp":1791440813906,"version":"4.3.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2590,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Supraphysiological insulin and incretin responses to a cereal-based diet have been described in horses and ponies with insulin dysregulation (ID). However, the hormonal responses to grazing have not yet been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if there is a difference in the insulin and incretin responses to grazing pasture between insulin-dysregulated and healthy ponies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A cohort of 16 ponies comprising 5 with normal insulin regulation (NIR), 6 with moderate ID (MID), and 5 with severe ID (SID).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case-control study, an oral glucose test (OGT) was used to determine the insulin responsiveness of each pony to PO carbohydrate before grazing pasture (4\u2009hours) for 3 consecutive days. Serial blood samples collected during grazing were analyzed for glucose, insulin, glucose-dependent insulinotropic peptide (GIP) and active glucagon-like peptide-1 (aGLP-1), and compared among pony groups and day of pasture access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The area under the insulin curve when grazing increased with ID severity (P\u2009&amp;lt;\u2009.03). The median (range) maximal insulin concentration was greater in the MID (72.5 [129] \u03bcIU\/mL) and SID (255 [338.5] \u03bcIU\/mL) groups, compared to the NIR (11.7 [24.9] \u03bcIU\/mL) group (P\u2009&amp;lt;\u2009.03) and occurred within 2-4\u2009hours of grazing. Postprandial OGT insulin concentration was positively correlated with 2\u2009hours post-grazing insulin across all 3 grazing days (P\u2009\u2264\u2009.03). The aGLP-1 and GIP concentrations increased in response to grazing but did not differ among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Grazing pasture provoked an increased insulin and incretin response in insulin-dysregulated ponies within 4\u2009hours of grazing. The pasture and OGT insulin concentrations were correlated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15363","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:54:16Z","timestamp":1543798456000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Insulin and incretin responses to grazing in insulin-dysregulated and healthy ponies"],"prefix":"10.1093","volume":"33","author":[{"given":"Danielle M.","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Science and Engineering Faculty, Queensland University of Technology Department of Bioscience, , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Animal Health Foundation , Pacific, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin N.","family":"Sillence","sequence":"additional","affiliation":[{"name":"Science and Engineering Faculty, Queensland University of Technology Department of Bioscience, , Brisbane, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Pollitt","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland , Gatton, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-3642","authenticated-orcid":false,"given":"Melody A.","family":"de Laat","sequence":"additional","affiliation":[{"name":"Science and Engineering Faculty, Queensland University of Technology Department of Bioscience, , Brisbane, 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