{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:10:32Z","timestamp":1787317832993,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2531,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T00:00:00Z","timestamp":1544832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Efficacy of PO cobalamin (Cbl) supplementation in dogs with hereditary Cbl malabsorption (Imerslund-Gr\u00e4sbeck syndrome, IGS) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate PO Cbl supplementation in Beagles with IGS previously treated parenterally. We hypothesized that 1\u2009mg cyano-Cbl daily PO would maintain clinical and metabolic remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Three client-owned Beagles with IGS and 48 healthy control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Daily PO cyanocobalamin (cyano-Cbl; 1\u2009mg) supplementation was monitored for 13 (2 dogs) and 8\u2009months (1 dog). Health status was assessed by owner observations. Methylmalonic acid (MMA)-to-creatinine concentrations were measured using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-TMS) method on urine samples collected monthly. Concurrent measurements of serum MMA concentration (n\u2009=\u20097; UPLC-TMS) were available for 1 dog.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All dogs remained in excellent health during PO supplementation. Urine MMA remained consistently low in 2 dogs (median, 2.5\u2009mmol\/mol creatinine; range, 1.2-9; healthy dogs [n\u2009=\u200930], median, 2.9\u2009mmol\/mol creatinine; range, 1.3-76.5). Urine MMA ranged from 38.9-84.9\u2009mmol\/mol creatinine during the first 6\u2009months in 1 dog already known to excrete comparable amounts when supplemented parenterally. Brief antibiotic treatment for an unrelated condition after 6\u2009months resulted in low urine MMA (median, 2.8\u2009mmol\/mol creatinine; range, 1.9-4.8) for the next 7\u2009months. All concurrent serum MMA concentrations (median, 651\u2009nmol\/L; range, 399-919) before and after month 6 were within the established reference interval (393-1476\u2009nmol\/L; n\u2009=\u200948).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>One milligram of cyano-Cbl daily PO appears efficacious for maintaining normal clinical status and normal cellular markers of Cbl metabolism in Beagles with IGS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15380","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:36:13Z","timestamp":1544920573000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gr\u00e4sbeck syndrome) maintains normal clinical and cellular cobalamin status"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3484","authenticated-orcid":false,"given":"Peter H.","family":"Kook","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hersberger","sequence":"additional","affiliation":[{"name":"University Children's Hospital Zurich Department of Clinical Chemistry, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"2026020922221937800_jvim15380-bib-0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.med.51.1.357","article-title":"Current concepts in cobalamin 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