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Correlations between height and metabolic traits were assessed by Pearson's correlation coefficients. Complementary genome-wide analysis methods were used to identify a region of interest (ROI) for height and metabolic traits, determine the fraction of heritability contributed by the ROI, and identify candidate genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was an inverse relationship between height and baseline insulin (\u22120.26) in ponies. Genomic signature of selection and association analyses for both height and insulin identified the same ~1.3 megabase region on chromosome 6 that contained a shared ancestral haplotype between these traits. The ROI contributed ~40% of the heritability for height and ~20% of the heritability for insulin. High-mobility group AT-hook 2 was identified as a candidate gene, and Sanger sequencing detected a c.83G&amp;gt;A (p.G28E) variant associated with height in Shetland ponies. In our cohort of ponies, the A allele had a frequency of 0.76, was strongly correlated with height (\u22120.75), and was low to moderately correlated with metabolic traits including: insulin (0.32), insulin after an oral sugar test (0.25), non-esterified fatty acids (0.19), and triglyceride (0.22) concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>These data have important implications for identifying individuals at risk for EMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15403","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T04:29:29Z","timestamp":1548131369000},"page":"942-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of an\n                    <i>HMGA2<\/i>\n                    variant for pleiotropic effects on height and metabolic traits in ponies"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9450-2893","authenticated-orcid":false,"given":"Elaine M.","family":"Norton","sequence":"first","affiliation":[{"name":"University of Minnesota Veterinary Population Medicine Department, , St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Avila","sequence":"additional","affiliation":[{"name":"University of Minnesota Veterinary Population Medicine Department, , St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichol E.","family":"Schultz","sequence":"additional","affiliation":[{"name":"University of Minnesota Veterinary Population Medicine Department, , St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Mickelson","sequence":"additional","affiliation":[{"name":"University of Minnesota Veterinary Biomedical Sciences Department, , St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray J.","family":"Geor","sequence":"additional","affiliation":[{"name":"Massey University, College of Sciences , Palmerston North,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"McCue","sequence":"additional","affiliation":[{"name":"University of Minnesota Veterinary Population Medicine Department, , St. Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"2026020922235540800_jvim15403-bib-0001","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1939-1676.2010.0503.x","article-title":"Equine metabolic syndrome","volume":"24","author":"Frank","year":"2010","journal-title":"J Vet Intern 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