{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:43:50Z","timestamp":1770745430359,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2470,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>One of the remaining questions in treating dogs with internal hydrocephalus is the association between the decrease of ventricular volume and re-expansion of cerebral parenchyma with clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>A decrease in ventricular volume and re-expansion of brain tissue occur after ventriculoperitoneal shunting (VPS). Clinical improvement defined by resolution of \u22651 clinical signs is associated with decreased size of cerebral ventricles and that the extent of change in ventricular size is associated with clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-five client-owned dogs with newly diagnosed communicating internal hydrocephalus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ventricular volume, brain volume, and clinical status of dogs that underwent VPS were measured before and 3\u2009months after surgery. Multiple logistic regression analysis was performed to assess the influence of decrease in ventricular size in addition to the covariates \u201cage of the animal\u201d and \u201cduration of clinical signs before surgery\u201d on improvement of clinical signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Decreased volume of cerebral ventricles was associated with resolution of \u22651 preoperative clinical sign (P &amp;lt;\u2009.003). The covariates \u201cage of the animal\u201d and \u201cduration of clinical signs\u201d were not associated with improvement of clinical signs. The percentage decrease in ventricular size was associated with resolution of ataxia (P =\u2009.008) and obtundation (P =\u2009.011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>The decrease in ventricular volume and increase in brain parenchyma after VPS are associated with improvement in clinical signs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15468","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T07:35:56Z","timestamp":1554708956000},"page":"1368-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between improvement of clinical signs and decrease of ventricular volume after ventriculoperitoneal shunting in dogs with internal hydrocephalus"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4737","authenticated-orcid":false,"given":"Martin J.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Small Animal Clinic, Justus-Liebig-University Department of Veterinary Clinical Sciences, , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Hofheim , Hofheim,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Farke","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Justus-Liebig-University Department of Veterinary Clinical Sciences, , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Failling","sequence":"additional","affiliation":[{"name":"Unit for Biomathematics and Data Processing, Faculty of Veterinary Medicine, Justus Liebig-University-Giessen , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Kolecka","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Justus-Liebig-University Department of Veterinary Clinical Sciences, , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2026020922052733000_jvim15468-bib-0001","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2460\/ajvr.1979.40.03.411","article-title":"Epizootiologic features of canine hydrocephalus","volume":"40","author":"Selby","year":"1979","journal-title":"Am J Vet Res"},{"key":"2026020922052733000_jvim15468-bib-0002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cvsm.2009.09.008","article-title":"Hydrocephalus in dogs and 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