{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:31:54Z","timestamp":1770157914021,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2409,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data about congenital sensorineural deafness (CSD) in white blue-eyed cats derive mainly from research colonies, and information about client-owned cats is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the prevalence of CSD in a client-owned population of white purebred kittens and colored littermates in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred thirty-two solid white client-owned purebred kittens and 61 colored littermates, 6 to 21 weeks of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective (56 cases) and prospective (137 cases) study. Hearing was assessed by brainstem auditory evoked response testing, and the entire litter was tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Congenital sensorineural deafness was diagnosed only in solid white kittens, with a prevalence of 30.3% (15.9% bilateral, 14.4% unilateral). The prevalence of CSD was significantly higher in white kittens with 1 (44.4%) or 2 (50%) blue irises than in those without blue irises (22.2%). Kittens with at least 1 blue iris were 3.2 times more likely to have CSD than kittens without blue irises. In solid white kittens, CSD was diagnosed in 7 of 15 (46.7%) Turkish Vankedisi, 8 of 18 (44.0%) Maine Coon, 18 of 41 (43.9%) Norwegian Forest, 3 of 11 (27.3%) British Shorthair, 2 of 12 (16.7%) Devon Rex, 2 of 12 (8.3%) Persian, 1 of 21 (4.8%) Russian, and 0 of 2 Sphinx. The prevalence of CSD was significantly different in Norwegian Forest, Maine Coon, and Turkish Vankedisi kittens compared with Persian or Russian kittens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>We identified a high prevalence of CSD in a population of client-owned purebred white kittens in the United Kingdom and suggest differences in breed-specific prevalence of CSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15515","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:10:54Z","timestamp":1559175054000},"page":"1707-1713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of congenital sensorineural deafness in a population of client-owned purebred kittens in the United Kingdom"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-1011","authenticated-orcid":false,"given":"Lorenzo","family":"Mari","sequence":"first","affiliation":[{"name":"Neurology\/Neurosurgery Service, Center for Small Animal Studies, Animal Health Trust , Newmarket,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Freeman","sequence":"additional","affiliation":[{"name":"Neurology\/Neurosurgery Service, Center for Small Animal Studies, Animal Health Trust , Newmarket,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Van Dijk","sequence":"additional","affiliation":[{"name":"Centre for Preventive Medicine, Animal Health Trust , Newmarket,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"De Risio","sequence":"additional","affiliation":[{"name":"Neurology\/Neurosurgery Service, Center for Small Animal Studies, Animal Health Trust , Newmarket,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2026020304350707900_jvim15515-bib-0001","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cvsm.2012.08.008","article-title":"Feline deafness","volume":"42","author":"Ryugo","year":"2012","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020304350707900_jvim15515-bib-0002","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1098612X17695062","article-title":"Hearing disorders in cats","volume":"19","author":"Strain","year":"2017","journal-title":"J Feline Med Surg"},{"key":"2026020304350707900_jvim15515-bib-0003","first-page":"178","article-title":"White cats with blue eyes are always deaf","volume":"1","author":"Bree","year":"1829","journal-title":"Mag Nat Hist"},{"key":"2026020304350707900_jvim15515-bib-0004","first-page":"18","article-title":"On the Origin of Species by Means of Natural Selection","author":"Darwin","year":"1859"},{"key":"2026020304350707900_jvim15515-bib-0005","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jhered\/62.3.171","article-title":"White fur, blue eyes, and deafness in the domestic cat","volume":"62","author":"Bergsma","year":"1971","journal-title":"J Hered"},{"key":"2026020304350707900_jvim15515-bib-0006","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1098\/rspb.1965.0030","article-title":"Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat","volume":"162","author":"Bosher","year":"1965","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"2026020304350707900_jvim15515-bib-0007","first-page":"609","article-title":"Hereditary deafness in the white cat","volume":"6","author":"Delack","year":"1984","journal-title":"Compend Contin Educ Pract"},{"key":"2026020304350707900_jvim15515-bib-0008","first-page":"1","article-title":"Hereditary deafness in the white cat","volume":"314","author":"Mair","year":"1973","journal-title":"Acta Otolaryngol Suppl"},{"key":"2026020304350707900_jvim15515-bib-0009","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5955(81)90045-9","article-title":"Variability of the hereditary deafness in the white cat. 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