{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:48Z","timestamp":1770745068002,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2347,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005350","name":"American Association of Equine Practitioners Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005350","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Churchill Downs"},{"name":"Del Mar Thoroughbred Club"},{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Keeneland Racetrack"},{"name":"Kentucky Downs"},{"name":"New York Racing Association"},{"name":"Oak Tree Racing Association"},{"name":"Oaklawn Racetrack"},{"name":"The Stronach Group"},{"name":"Thoroughbred Horseman's Association"},{"DOI":"10.13039\/100005350","name":"American Association of Equine Practitioners Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Public pressure exists in the United States to eliminate race-day furosemide administration despite its efficacy in decreasing the severity of equine exercise pulmonary hemorrhage (EIPH). No effective alternative prophylaxis strategies have been identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate alternative protocols to race-day furosemide that might mitigate EIPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seven fit Thoroughbreds with recent EIPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Double-blinded placebo-controlled Latin square crossover using a treadmill followed by a blinded placebo-controlled crossover study at a racetrack. First, horses exercised supramaximally to fatigue 24\u2009hours after initiating 5 EIPH prophylaxis protocols: 0.5 and 1.0 mg\/kg furosemide IV 24\u2009hours pre-exercise with and without controlled access to water, and 24\u2009hour controlled access to water. Effects were compared to those measured after giving a placebo 24\u2009hours pre-exercise, and 0.5 mg\/kg furosemide IV 4 hours pre-exercise. Bronchoalveolar lavage (BAL) erythrocyte count was determined 45-60\u2009minutes postexercise after endoscopy to assign an EIPH score. Data were analyzed using linear mixed effects models. The most promising protocol from the treadmill study was further evaluated in 6 horses using endoscopy and BAL after 1100\u2009m simulated races.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intravenous furosemide (0.5 mg\/kg) administered 24\u2009hours pre-exercise combined with controlled access to water decreased the severity of EIPH on the treadmill and at the racetrack.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Administering 0.5 mg\/kg furosemide 24\u2009hours pre-racing combined with controlling water intake may be a strategy to replace race-day furosemide administration for the management of EIPH. A larger study is indicated to further evaluate whether this protocol significantly mitigates EIPH severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15574","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:35:21Z","timestamp":1565339721000},"page":"2319-2326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of different protocols on the mitigation of exercise-induced pulmonary hemorrhage in horses when administered 24 hours before strenuous exercise"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-6245","authenticated-orcid":false,"given":"Warwick","family":"Bayly","sequence":"first","affiliation":[{"name":"Washington State University Department of Veterinary Clinical Sciences, , Pullman, 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