{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:35:04Z","timestamp":1770744904541,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":2354,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcranial magnetic stimulation (TMS) and recording of magnetic motor evoked potentials (MMEP) can detect neurological dysfunction in horses but cutoff values based on confirmed spinal cord dysfunction are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine latency time cutoff for neurological dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Five control horses and 17 horses with proprioceptive ataxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case-control study with receiver operating characteristic curve analysis, based on diagnostic imaging, TMS, and histopathological findings. Horses were included if all 3 examinations were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Diagnostic imaging and histopathology did not show abnormalities in the control group but confirmed spinal cord compression in 14 of 17 ataxic horses. In the remaining 3 horses, histopathological lesions were mild to severe, but diagnostic imaging did not confirm spinal cord compression. In control horses, latency time values of thoracic and pelvic limbs were significantly lower than in ataxic horses (20\u2009\u00b1\u20091 vs 34\u2009\u00b1\u200916\u2009milliseconds, P =\u2009.05; and 39\u2009\u00b1\u20091 vs 78\u2009\u00b1\u200926\u2009milliseconds, P =\u2009.004). Optimal cutoff values to detect spinal cord dysfunction were 22\u2009milliseconds (sensitivity [95% CI interval], 88% [73%-100%]; specificity, 100% [100%-100%]) in thoracic and 40\u2009milliseconds (sensitivity, 94% [83%-100%]; specificity, 100% [100%-100%]) in pelvic limbs. To detect spinal cord dysfunction caused by compression, the optimal cutoff for thoracic limbs remained 22\u2009milliseconds, while it increased to 43\u2009milliseconds in pelvic limbs (sensitivity, 100% [100%-100%]; specificity, 100% [100%-100%] for thoracic and pelvic limbs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Magnetic motor evoked potential analysis using these cutoff values is a promising diagnostic tool for spinal cord dysfunction diagnosis in horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15576","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T07:10:23Z","timestamp":1567753823000},"page":"2312-2318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-6127","authenticated-orcid":false,"given":"Joke","family":"Rijckaert","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Large Animal Internal Medicine, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-8433","authenticated-orcid":false,"given":"Bart","family":"Pardon","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Large Animal Internal Medicine, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Saey","sequence":"additional","affiliation":[{"name":"Bacteriology and Poultry Diseases, Ghent University Department of Pathology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Raes","sequence":"additional","affiliation":[{"name":"Ghent University Department of Veterinary Medical Imaging and Small Animal Orthopedics, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-6784","authenticated-orcid":false,"given":"Luc","family":"Van Ham","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Small Animal Department, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3721-872X","authenticated-orcid":false,"given":"Richard","family":"Ducatelle","sequence":"additional","affiliation":[{"name":"Bacteriology and Poultry Diseases, Ghent University Department of Pathology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-5241","authenticated-orcid":false,"given":"Gunther","family":"van Loon","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Large Animal Internal Medicine, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3436-0752","authenticated-orcid":false,"given":"Piet","family":"Deprez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Large Animal Internal Medicine, , 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