{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:20:52Z","timestamp":1784323252103,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2286,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:00:00Z","timestamp":1570838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D09FE-026"],"award-info":[{"award-number":["D09FE-026"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003516","name":"Winn Feline Foundation","doi-asserted-by":"publisher","award":["W-09-017"],"award-info":[{"award-number":["W-09-017"]}],"id":[{"id":"10.13039\/100003516","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D09FE\u2010026"],"award-info":[{"award-number":["D09FE\u2010026"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003516","name":"Winn Feline Foundation","doi-asserted-by":"publisher","award":["W\u201009\u2010017"],"award-info":[{"award-number":["W\u201009\u2010017"]}],"id":[{"id":"10.13039\/100003516","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize\/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner\/referring veterinarian interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2\u2009years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P =\u2009.48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates\/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P &amp;lt;\u2009.001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8\u2009years; pHCM, 8.6\u2009years; P =\u2009.10), but all-cause survival was significantly shorter in pHCM (P\u2009= .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15609","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T03:19:00Z","timestamp":1570850340000},"page":"2572-2586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-0573","authenticated-orcid":false,"given":"Philip R.","family":"Fox","sequence":"first","affiliation":[{"name":"Animal Medical Center , New York, New York,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-5654","authenticated-orcid":false,"given":"Bruce W.","family":"Keene","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University , Department of Clinical Sciences, Raleigh, North Carolina,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lamb","sequence":"additional","affiliation":[{"name":"Lamb Consulting , Minneapolis, Minnesota,","place":["U.S.A"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten 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