{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:44:36Z","timestamp":1780400676827,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2286,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunoglobulin G4-related disease (IgG4-RD), which affects many organ systems, has been recognized as a distinct clinical entity in human medicine for just over a decade but has not been previously identified in dogs. In humans, IgG4-RD is characterized by diffuse IgG4-positive lymphoplasmacytic infiltrates that commonly lead to increased serum concentrations of IgG4 and IgE, peripheral eosinophilia, tumorous swellings that often include the parotid salivary glands, obliterative phlebitis, and extensive fibrosis. Herein we describe the diagnosis, clinical progression, and successful treatment of IgG4-RD in an 8-year-old female spayed Husky mixed breed dog. Immunoglobulin G4-related disease should be considered as a differential diagnosis for dogs with vague clinical signs, lymphoplasmacytic swellings, restricted polyclonal gammopathy, eosinophilia or some combination of these findings.<\/jats:p>","DOI":"10.1111\/jvim.15624","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T04:39:25Z","timestamp":1572064765000},"page":"2732-2738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Immunoglobulin G4-related disease in a dog"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-117X","authenticated-orcid":false,"given":"Lydia J.","family":"Colopy","sequence":"first","affiliation":[{"name":"Veterinary Emergency Service, Veterinary Specialty Center , Middleton, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Biu","family":"Shiu","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Service, Veterinary Specialty Center , Middleton, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Veterinary Services, Marshfield Labs , Marshfield, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Avery","sequence":"additional","affiliation":[{"name":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University Department of Microbiology, , Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-8532","authenticated-orcid":false,"given":"Emily D.","family":"Rout","sequence":"additional","affiliation":[{"name":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University Department of Microbiology, , Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-8788","authenticated-orcid":false,"given":"A R.","family":"Moore","sequence":"additional","affiliation":[{"name":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University Department of Microbiology, , Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"issue":"6","key":"2026020304364986500_jvim15624-bib-0001","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1939-165X.2012.00462.x","article-title":"Diagnostic accuracy of electrophoretic analysis of native or defribrinated plasma using serum as a reference sample","volume":"41","author":"Errico","year":"2012","journal-title":"Vet Clin Pathol"},{"key":"2026020304364986500_jvim15624-bib-0002","article-title":"Validation and method comparison of the use of densitometry to quantify monoclonal proteins in canine sera","author":"Harris","journal-title":"Vet Clin Pathol"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0003","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/ccr3.639","article-title":"Idiopathic sclerosing orbital inflammation mimicking a malignant spindle cell tumor in a dog","volume":"4","author":"Marie Rzechorzek","year":"2016","journal-title":"Clin Case Rep"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0004","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1354\/vp.43-6-1022","article-title":"Brief communications and case reports eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian husky","volume":"1025","author":"Brellou","year":"2006","journal-title":"Vet Pathol"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/01652176.2015.1021493","article-title":"Recurrent intraluminal eosinophilic tracheal granuloma in a Siberian husky","volume":"35","author":"Adamama-Moraitou","year":"2015","journal-title":"Vet Q"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0006","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1748-5827.2005.tb00272.x","article-title":"Eyelid Eosinophilic granuloma in a Siberian husky","volume":"46","author":"Vercelli","year":"2005","journal-title":"J Small Anim Pract"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0022-1759(93)90295-I","article-title":"The separation and identification by monoclonal antibodies of dog IgG fractions","volume":"161","author":"Mazza","year":"1993","journal-title":"J Immunol Methods"},{"issue":"6","key":"2026020304364986500_jvim15624-bib-0008","doi-asserted-by":"crossref","first-page":"923","DOI":"10.4049\/jimmunol.98.5.923","article-title":"Canine immunoglobulins. 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