{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:13:33Z","timestamp":1790025213078,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2225,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One-hundred eighteen client-owned cats with lower urinary tract carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age of affected cats was 15\u2009years (range, 5.0-20.8\u2009years) and median duration of clinical signs was 30\u2009days (range, 0-730\u2009days). The trigone was the most common tumor location (32\/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression-free survival and survival time for all cats were 113\u2009days (95% confidence interval [CI], 69-153) and 155\u2009days (95% CI, 110-222), respectively. Survival increased significantly (P &amp;lt;\u2009.001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95% CI, 0.33-0.93) were significantly associated with longer survival times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The results support treatment using partial cystectomy and NSAIDs in cats with TCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15656","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T07:38:59Z","timestamp":1573630739000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases"],"prefix":"10.1093","volume":"34","author":[{"given":"Maureen A.","family":"Griffin","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-156X","authenticated-orcid":false,"given":"William T. N.","family":"Culp","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ellis","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Tuohy","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Colorado State University , Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Perry","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University 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Athens,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hash","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-6049","authenticated-orcid":false,"given":"Kyle","family":"Mathews","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[{"name":"VCA Canada\u2014Alta Vista Animal Hospital , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois , Urbana, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-5113","authenticated-orcid":false,"given":"Carrie A.","family":"Palm","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Balsa","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp D.","family":"Mayhew","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis , Davis, 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