{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:32:12Z","timestamp":1770964332865,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2043,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cortical atrophy has been identified using magnetic resonance imaging (MRI) in humans and dogs with Lafora disease (LD). In humans, proton magnetic resonance spectroscopy (1HMRS) of the brain indicates decreased N-acetyl-aspartate (NAA) relative to other brain metabolites. Brain 1HMRS findings in dogs with LD are lacking. A 6-year-old female Beagle was presented with a history of a single generalized tonic-clonic seizure and episodic reflex myoclonus. Clinical, hematological, and neurological examination findings and 3-Tesla MRI of the brain were unremarkable. Brain 1HMRS with voxel positioning in the thalamus was performed in the affected Beagle. It identified decreased amounts of NAA, glutamate-glutamine complex, and increased total choline and phosphoethanolamine relative to water and total creatine compared with the reference range in healthy control Beagles. A subsequent genetic test confirmed LD. Abnormalities in 1HMRS despite lack of changes with conventional MRI were identified in a dog with LD.<\/jats:p>","DOI":"10.1111\/jvim.15799","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T14:08:50Z","timestamp":1589724530000},"page":"1594-1598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Brain proton magnetic resonance spectroscopy findings in a Beagle dog with genetically confirmed Lafora disease"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-4717","authenticated-orcid":false,"given":"Neringa","family":"Alisauskaite","sequence":"first","affiliation":[{"name":"Neurology Service , Department of Small Animal Surgery, Vetsuisse Faculty, University of Zurich, Zurich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-7845","authenticated-orcid":false,"given":"Katrin","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Neurology Service , Department of Small Animal Surgery, Vetsuisse Faculty, University of Zurich, Zurich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Dennler","sequence":"additional","affiliation":[{"name":"Clinic for Diagnostic Imaging , Department of Diagnostics and Clinical Services, Vetsuisse Faculty, University of Zurich, Zurich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-7783","authenticated-orcid":false,"given":"Niklaus","family":"Z\u00f6lch","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine, University of Zurich Department of Forensic Medicine and Imaging, , 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