{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:33:11Z","timestamp":1770150791944,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2043,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periventricular nodular heterotopia is a common neuronal malformation in humans, often leading to epilepsy and other neurologic diseases. A 2-month-old female Chihuahua weighing 750\u2009g was examined because of a history of epileptic seizures and abnormalities in gait and behavior. Results of the clinical examination were consistent with a multifocal neurologic disease with localization in the forebrain and spinovestibular system. The magnetic resonance imaging showed multiple bilateral periventricular nodules isointense to gray matter and ventriculomegaly. Histopathological and immunohistological examination of the brain revealed that periventricular nodules consisted of neurons, fewer astrocytes, and some oligodendroglia consistent with periventricular nodular heterotopias.<\/jats:p>","DOI":"10.1111\/jvim.15803","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T04:40:30Z","timestamp":1590208830000},"page":"1570-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Periventricular nodular heterotopia in a Chihuahua"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-5174","authenticated-orcid":false,"given":"Leonie F.","family":"Herkommer","sequence":"first","affiliation":[{"name":"Institute for Veterinary-Pathology, Justus-Liebig-University Giessen , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Henrich","sequence":"additional","affiliation":[{"name":"Institute for Veterinary-Pathology, Justus-Liebig-University Giessen , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Herden","sequence":"additional","affiliation":[{"name":"Institute for Veterinary-Pathology, Justus-Liebig-University Giessen , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4737","authenticated-orcid":false,"given":"Martin J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Small Animal Clinic, Neurosurgery, Neuroradiology and Clinical Neurology, Justus-Liebig-University Giessen Department of Veterinary Clinical Sciences, , Giessen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"4","key":"2026020302591175500_jvim15803-bib-0001","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2007-973750","article-title":"A classification scheme for malformations of cortical development","volume":"27","author":"Barkovich","year":"1996","journal-title":"Neuropediatrics"},{"issue":"4","key":"2026020302591175500_jvim15803-bib-0002","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/WNL.55.11.1603","article-title":"Gray matter heterotopia","volume":"55","author":"Barkovich","year":"2000","journal-title":"Neurology"},{"issue":"4","key":"2026020302591175500_jvim15803-bib-0003","first-page":"290","article-title":"Morphologic characteristics of subcortical heterotopia: MR imaging study","volume":"21","author":"Barkovich","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"2026020302591175500_jvim15803-bib-0004","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1148\/radiographics.9.3.2727358","article-title":"Magnetic resonance imaging of disturbances in neuronal migration: illustration of an embryologic process","volume":"9","author":"Smith","year":"1989","journal-title":"Radiographics"},{"issue":"4","key":"2026020302591175500_jvim15803-bib-0005","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00401-002-0594-9","article-title":"Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex","volume":"104","author":"Kakita","year":"2002","journal-title":"Acta Neuropathol"},{"issue":"4","key":"2026020302591175500_jvim15803-bib-0006","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/brain\/118.5.1273","article-title":"Periventricular and subcortical nodular heterotopia. 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