{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:25Z","timestamp":1787015725757,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1981,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comparative Pathology and Mouse Phenotyping Shared Resource, Department of Veterinary Biosciences and the Comprehensive Cancer Center, the Ohio State University, Columbus OH","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}]},{"name":"World Small Animal Veterinary Association","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Comparative Pathology and Mouse Phenotyping Shared Resource, Department of Veterinary Biosciences and the Comprehensive Cancer Center, the Ohio State University, Columbus OH","award":["P30 CA016058"],"award-info":[{"award-number":["P30 CA016058"]}]},{"name":"World Small Animal Veterinary Association","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Focal segmental glomerulosclerosis (FSGS) is a common cause of nonimmune complex glomerulopathy and the prognosis and clinicopathologic findings associated with this condition have not been described in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the presentation and identify clinical factors associated with the survival of dogs with FSGS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seventy-seven dogs diagnosed with FSGS based on evaluation of renal biopsy samples submitted to the International Veterinary Renal Pathology Service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of medical records of dogs biopsied for evaluation of proteinuria between January 2015 and May 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of FSGS among all dogs biopsied for proteinuria was 26%. Significantly more females (48; 62.3%) than males (29; 37.7%) were affected (P = .04). At the time of biopsy, median serum creatinine concentration (SCr) was 1.2 mg\/dL (range, 0.3-8.7), median serum albumin concentration (Alb) was 2.8 g\/dL (range, 1.1-4.6), median systolic blood pressure was 153.5\u2009mm\u2009Hg (range, 95-260), and median urine protein : creatinine ratio was 5.9 (range, 1.4-22). Median survival time after biopsy was 258\u2009days (range, 26-1003) for dogs that died from all causes (n = 32). Factors that were associated with a shorter survival time included SCr\u2009\u2265\u20092.1 mg\/dL (P\u2009&amp;lt;\u2009.01) and Alb\u2009&amp;lt;\u20092 g\/dL (P\u2009&amp;lt;\u2009.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Most dogs with FSGS were female, and although commonly hypertensive, azotemia, severe hypoalbuminemia and ascites or edema were observed infrequently. Variables significantly associated with survival time were SCr and Alb.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15837","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T03:44:10Z","timestamp":1594093450000},"page":"1948-1956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinicopathologic characteristics, pathology, and prognosis of 77 dogs with focal segmental glomerulosclerosis"],"prefix":"10.1093","volume":"34","author":[{"given":"Sarah K.","family":"Lorbach","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, The Ohio State University Department of Veterinary Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Hokamp","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, The Ohio State University Department of 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