{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:34:58Z","timestamp":1787884498463,"version":"build-2784847793"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1981,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic hypertension (SH) is common in dogs with hyperadrenocorticism (HAC) however there are not many studies assessing its prevalence and risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence and severity of SH in dogs with HAC and its association with clinical and laboratory findings to identify potential risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-six client owned dogs with spontaneous HAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cross-sectional study. Medical records of dogs with HAC were reviewed. Systolic blood pressure (SBP) was measured using Doppler ultrasonography. Clinical signs, physical examination findings and clinicopathologic data (CBC, serum biochemistry and electrolytes, urinalysis and urinary culture, and adrenal function tests) were reviewed for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of SH (\u2265150\u2009mm Hg) was 82% (54\/66) and prevalence of severe SH (\u2265180\u2009mm Hg) was 46% (30\/66). All dogs with thrombocytosis had SH (P = .002), and a platelet count \u2265438 \u00d7\u2009103\/\u03bcL was 100% specific and 61.1% sensitive to predict SH (AUC = .802, P =\u2009.001). Median potassium levels were lower in hypertensive dogs (4.1 mEq\/L, range 3.1-5.4 mEq\/L) than in normotensive ones (4.5 mEq\/L, range 4.0-5.0 mEq\/L) (P =\u2009.007). Dogs with UPC\u2009\u2265\u20090.5 had higher median SBP than those without proteinuria (P =\u2009.03). Dogs with concurrent diabetes mellitus seemed to have a reduced risk of SH (OR = .118, 95%CI = .022-.626, P =\u2009.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Systemic hypertension is common in dogs with HAC and is frequently severe. Blood pressure should be routinely assessed in these dogs, especially if thrombocytosis, proteinuria or low potassium concentrations are present.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15841","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T09:26:18Z","timestamp":1593681978000},"page":"1768-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence and risk factors associated with systemic hypertension in dogs with spontaneous hyperadrenocorticism"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-9069","authenticated-orcid":false,"given":"Paula","family":"Garc\u00eda San Jos\u00e9","sequence":"first","affiliation":[{"name":"Veterinary Faculty, Complutense University of Madrid Department of Animal Medicine and Surgery, , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-7689","authenticated-orcid":false,"given":"Carolina","family":"Arenas Bermejo","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Anicura Hospital Veterinario Valencia Sur , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Clares Moral","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital Complutense, Complutense University of Madrid , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cuesta Alvaro","sequence":"additional","affiliation":[{"name":"Computing Services, Research Support, Complutense University of Madrid , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-0083","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"P\u00e9rez Alenza","sequence":"additional","affiliation":[{"name":"Veterinary Faculty, Complutense University of Madrid Department of Animal Medicine and Surgery, , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"issue":"5","key":"2026020922071533900_jvim15841-bib-0001","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.domaniend.2004.11.001","article-title":"Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone","volume":"28","author":"Galac","year":"2005","journal-title":"Domest Anim Endocrinol"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tvjl.2007.04.008","article-title":"ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolemia in a dog: a case report","volume":"177","author":"Galac","year":"2008","journal-title":"Vet J"},{"key":"2026020922071533900_jvim15841-bib-0003","first-page":"4345","article-title":"Textbook of veterinary internal medicine. 2","author":"P\u00e9rez Alenza","year":"2017","edition":"8"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0004","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2213-8587(16)00086-3","article-title":"Complications of Cushing's syndrome: state of the art","volume":"4","author":"Pivonello","year":"2016","journal-title":"Lancet Diab Endocrinol"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/HJH.0000000000000415","article-title":"The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications","volume":"33","author":"Isidori","year":"2015","journal-title":"J Hypertens"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0006","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.beem.2006.07.006","article-title":"Hypertension in Cushing's syndrome","volume":"20","author":"Magiakou","year":"2006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0007","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2265.2004.02168.x","article-title":"High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO\/ISH guidelines","volume":"61","author":"Mancini","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2026020922071533900_jvim15841-bib-0008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/EJE-11-0272","article-title":"The European Registry on Cushing's syndrome: 2-year experience. 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