{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:41Z","timestamp":1770745061636,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>A 10-month-old neutered male mixed breed dog was presented for assessment of poorly controlled seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Findings<\/jats:title>\n                    <jats:p>Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15907","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T05:52:51Z","timestamp":1601704371000},"page":"2682-2686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aventriculi associated with holoprosencephaly in a dog"],"prefix":"10.1093","volume":"34","author":[{"given":"Laura","family":"Barnard","sequence":"first","affiliation":[{"name":"Canada West Veterinary Specialists , Vancouver, British Columbia,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexane","family":"Durand","sequence":"additional","affiliation":[{"name":"University of Bern Department of Clinical Veterinary Sciences, , Bern,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Blume","sequence":"additional","affiliation":[{"name":"Veterinary Imaging Solutions LLC , Milton, Vermont,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Madison \u2013 Wisconsin Department of Pathological Sciences, , Madison, Wisconsin,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-2546","authenticated-orcid":false,"given":"Starr","family":"Cameron","sequence":"additional","affiliation":[{"name":"University of Wisconsin \u2013 Madison Department of Medical Sciences, , Madison, Wisconsin,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"issue":"6","key":"2026020922122377800_jvim15907-bib-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/vru.12347","article-title":"Multidetector computed tomographic and low-field magnetic resonance imaging anatomy of the quadrigeminal cistern and characterization of supracollicular fluid accumulations in dogs","volume":"57","author":"Bertolini","year":"2016","journal-title":"Vet Radiol 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