{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:49:34Z","timestamp":1787068174676,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Localized splenic histiocytic sarcoma (HS) in dogs is a poorly understood disease, and could have longer survival times than disseminated or hemophagocytic HS. Understanding the clinical behavior of localized splenic HS can refine treatment recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical characteristics and outcomes of dogs with localized splenic HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fourteen client-owned dogs with histologically confirmed splenic HS that received splenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multi-institutional retrospective case series\u2014medical records of dogs with splenic HS were reviewed. Dog signalment, clinicopathologic data, primary and adjuvant treatments, and outcomes were obtained. Survival data were calculated using Kaplan-Meier analysis. Dog variables such as age, weight, platelet counts were reported using descriptive statistics. The Cox proportional hazards regression method was used to determine whether potential risk factors (weight, age, albumin level, hematocrit, and platelet count) were associated with PFI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median survival time for the dogs in this study was 427\u2009days. Twelve dogs received adjuvant lomustine-based chemotherapy. Five dogs (35.7%) were suspected or confirmed to have developed metastatic disease. Eleven dogs died of disease, 1 dog died of unrelated cause, and 2 dogs were alive at final follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Significance<\/jats:title>\n                    <jats:p>Histiocytic sarcoma in dogs can manifest as a localized form in the spleen. Dogs with localized splenic HS treated with surgery\u2009\u00b1\u2009chemotherapy can experience survival times over a year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15910","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T12:16:25Z","timestamp":1601295385000},"page":"2645-2650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical outcomes in dogs with localized splenic histiocytic sarcoma treated with splenectomy with or without adjuvant chemotherapy"],"prefix":"10.1093","volume":"34","author":[{"given":"Max","family":"Latifi","sequence":"first","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, Virginia,","place":["USA"]},{"name":"University of Missouri College of Veterinary Medicine Department of Veterinary Medicine and Surgery, , Columbia, MO,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-3841","authenticated-orcid":false,"given":"Joanne L.","family":"Tuohy","sequence":"additional","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, Virginia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Coutermarsh-Ott","sequence":"additional","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine Department of Biomedical Sciences and Pathobiology, , Blacksburg, Virginia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna L.","family":"Klahn","sequence":"additional","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, Virginia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Leeper","sequence":"additional","affiliation":[{"name":"Carlson College of Veterinary Medicine, Oregon State University Department of Clinical Sciences, , Corvallis, Oregon,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Dervisis","sequence":"additional","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, Virginia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2026020922130281000_jvim15910-bib-0001","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0300985813510413","article-title":"A review of histiocytic diseases of dogs and cats","volume":"51","author":"Moore","year":"2014","journal-title":"Vet Pathol"},{"key":"2026020922130281000_jvim15910-bib-0002","first-page":"1041","article-title":"Canine histiocytic neoplasia: an overview","volume":"48","author":"Fulmer","year":"2007","journal-title":"Can Vet J"},{"key":"2026020922130281000_jvim15910-bib-0003","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/941275","article-title":"Breed-predispositions to cancer in pedigree dogs","volume":"2013","author":"Dobson","year":"2013","journal-title":"ISRN Vet Sci"},{"key":"2026020922130281000_jvim15910-bib-0004","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1354\/vp.39-1-74","article-title":"Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs","volume":"39","author":"Affolter","year":"2002","journal-title":"Vet Pathol"},{"key":"2026020922130281000_jvim15910-bib-0005","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1354\/vp.43-5-632","article-title":"Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages","volume":"43","author":"Moore","year":"2006","journal-title":"Vet Pathol"},{"key":"2026020922130281000_jvim15910-bib-0006","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/vco.12437","article-title":"Primary pulmonary histiocytic sarcoma in dogs: a retrospective analysis of 37 cases (2000-2015)","volume":"16","author":"Marlowe","year":"2018","journal-title":"Vet Comp Oncol"},{"key":"2026020922130281000_jvim15910-bib-0007","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/vco.12252","article-title":"Clinical prognostic factors in canine histiocytic sarcoma","volume":"15","author":"Dervisis","year":"2017","journal-title":"Vet Comp Oncol"},{"key":"2026020922130281000_jvim15910-bib-0008","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1354\/vp.39-1-66","article-title":"The diagnosis and prognosis of synovial tumors in dogs: 35 cases","volume":"39","author":"Craig","year":"2002","journal-title":"Vet Pathol"},{"key":"2026020922130281000_jvim15910-bib-0009","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1476-5810.2006.00090.x","article-title":"Histiocytic sarcomas in flat-coated retrievers: a summary of 37 cases (November 1998-March 2005)","volume":"4","author":"Fidel","year":"2006","journal-title":"Vet Comp Oncol"},{"key":"2026020922130281000_jvim15910-bib-0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1939-1676.2007.tb02937.x","article-title":"CCNU for the treatment of dogs with histiocytic sarcoma","volume":"21","author":"Skorupski","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026020922130281000_jvim15910-bib-0011","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/jsap.12354","article-title":"Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma","volume":"56","author":"Cannon","year":"2015","journal-title":"J Small Anim Pract"},{"key":"2026020922130281000_jvim15910-bib-0012","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2460\/javma.239.1.90","article-title":"Evaluation and comparison of outcomes in dogs with periarticular and nonperiarticular histiocytic sarcoma","volume":"239","author":"Klahn","year":"2011","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922130281000_jvim15910-bib-0013","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0300985810385153","article-title":"The clinical presentation and histopathologic-immunohistochemical classification of histiocytic sarcomas in the Flat Coated Retriever","volume":"48","author":"Constantino-Casas","year":"2011","journal-title":"Vet Pathol"},{"key":"2026020922130281000_jvim15910-bib-0014","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00441-007-0474-7","article-title":"Allograft inflammatory factor-1\/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis","volume":"330","author":"Kohler","year":"2007","journal-title":"Cell Tissue Res"},{"key":"2026020922130281000_jvim15910-bib-0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jcpa.2014.07.003","article-title":"Immunohistochemical expression of ionized calcium binding adapter molecule 1 in cutaneous histiocytic proliferative, neoplastic and inflammatory disorders of dogs and cats","volume":"151","author":"Pierezan","year":"2014","journal-title":"J Comp Pathol"},{"key":"2026020922130281000_jvim15910-bib-0016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/104063871102300123","article-title":"Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs","volume":"23","author":"Ide","year":"2011","journal-title":"J Vet Diagn Invest"},{"key":"2026020922130281000_jvim15910-bib-0017","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1292\/jvms.09-0312","article-title":"Histiocytic sarcoma in the brain of a cat","volume":"72","author":"Ide","year":"2010","journal-title":"J Vet Med Sci"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.15910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.15910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/34\/6\/2645\/66660874\/jvim15910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/34\/6\/2645\/66660874\/jvim15910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:26:08Z","timestamp":1770693968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/34\/6\/2645\/8448325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.15910","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,11,1]]},"assertion":[{"value":"2019-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}