{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:57:04Z","timestamp":1792112224126,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pimobendan is frequently used off-label for treatments of cats with congestive heart failure (CHF). Concern exists regarding the safety of pimobendan in cats with outflow tract obstruction (OTO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In cats treated with pimobendan, incidence of adverse effects will not differ between cats with OTO vs cats with nonobstructive cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Two-hundred sixty cats with CHF (57 with OTO, 203 with nonobstructive disease).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective medical record review. Groups were compared using 2-sample t-tests, Wilcoxon rank-sum tests, and Fisher exact tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to cats with nonobstructive cardiomyopathy, cats with OTO were younger (8.9 [interquartile range (IQR) 6.6] vs 10.8 [6.3] years, P =\u2009.0036), more likely to have a heart murmur (51\/57 [90%] vs 76\/203 [37.8%] cats, P &amp;lt;\u2009.0001), more likely to manifest CHF as pulmonary edema (53\/57 [83%] vs 144\/203 [70.9%] cats, P =\u2009.0004), and less likely to have pleural effusion (19\/57 [33%] vs 122\/203 [60.1%] cats, P =\u2009.0005). Adverse effects suspected to be related to pimobendan administration occurred in 12\/260 cats (4.6%), including 11\/203 cats (5.4%) with nonobstructive cardiomyopathy and 1\/57 cat (2%) with OTO (P =\u2009.7). Pimobendan was discontinued due to adverse effects in 4\/260 cats (1.5%), 3 with nonobstructive disease and 1 with OTO (P =\u20091.0). Acute adverse hemodynamic effects after pimobendan administration were not detected in any cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Pimobendan is well tolerated in cats with cardiomyopathy and CHF, regardless of the presence of OTO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15920","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T13:48:27Z","timestamp":1602078507000},"page":"2211-2222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Retrospective evaluation of the safety and tolerability of pimobendan in cats with obstructive vs nonobstructive cardiomyopathy"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-7916","authenticated-orcid":false,"given":"Jessica 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