{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:47:36Z","timestamp":1770745656434,"version":"3.49.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"BodeVet Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf-lives and can be easily transported, stored, and administered in various settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of a novel trehalose-stabilized canine lyophilized platelet product in thrombocytopenic dogs with clinically-evident bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighty-eight dogs with platelet counts &amp;lt;50\u2009\u00d7\u2009103\/\u03bcL and a standardized bleeding assessment tool (DOGiBAT) score\u2009\u22652.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter, randomized, non-blinded, non-inferiority clinical trial comparing dimethyl sulfoxide (DMSO)-stabilized cryopreserved platelet concentrates (CPP) with trehalose-stabilized lyophilized platelets (LP) for control of bleeding in thrombocytopenic dogs. Dogs were randomized to receive 3\u2009\u00d7\u2009109 platelets\/kg of LP or CPP. Primary outcome measures were change in DOGiBAT score, platelet count, need for additional red cell transfusion and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty dogs received LP and 38 received CPP. Baseline demographics and clinical characteristics of both groups were comparable. At 1-hour post-transfusion, LP were superior for change in DOGiBAT score, and non-inferior at 24-hours post-transfusion. The LP were non-inferior to CPP for change in platelet count, need for additional red blood cell units, and survival to discharge. The LP were superior for change in hematocrit at 1-hour post-transfusion, and non-inferior at 24-hours. No adverse effects were noted in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>A novel trehalose-stabilized canine LP product appears to be logistically superior and is clinically non-inferior to DMSO-stabilized canine CPP for management of bleeding in thrombocytopenic dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15922","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T08:42:59Z","timestamp":1601887379000},"page":"2384-2397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-6987","authenticated-orcid":false,"given":"Robert","family":"Goggs","sequence":"first","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-2936","authenticated-orcid":false,"given":"Benjamin M.","family":"Brainard","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Georgia Department of Small Animal Medicine and Surgery, , Athens, Georgia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana N.","family":"LeVine","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University Department of Veterinary Clinical Sciences, , Ames, Iowa,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Calabro","sequence":"additional","affiliation":[{"name":"Friendship Veterinary Hospital , Norfolk, Virginia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyn","family":"Harrell","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Mills","sequence":"additional","affiliation":[{"name":"VCA Clinical Research, VCA Animal Hospitals , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Stone","sequence":"additional","affiliation":[{"name":"Blue Pearl Pet Hospital , Spring, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Davidson","sequence":"additional","affiliation":[{"name":"Blue Pearl Pet Hospital , Paramus, New Jersey,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Iacovetta","sequence":"additional","affiliation":[{"name":"Blue Pearl Pet Hospital , Forest Hills, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Harris","sequence":"additional","affiliation":[{"name":"Blue Pearl Pet Hospital , Clearwater, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gicking","sequence":"additional","affiliation":[{"name":"Blue Pearl Pet Hospital , Tampa, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Aslanian","sequence":"additional","affiliation":[{"name":"VCA Diagnostic Clinic , Dallas, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Ziegler","sequence":"additional","affiliation":[{"name":"VCA Great Lakes , Warrensville Heights, Ohio,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Fulcher","sequence":"additional","affiliation":[{"name":"Blue Pearl Science , Tampa, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Lightfoot","sequence":"additional","affiliation":[{"name":"Blue Pearl Science , Tampa, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-1804","authenticated-orcid":false,"given":"Meredith","family":"Miller","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-7155","authenticated-orcid":false,"given":"John","family":"Loftus","sequence":"additional","affiliation":[{"name":"Cornell University College of Veterinary Medicine Department of Clinical Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Walton","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University Department of Veterinary Clinical Sciences, , Ames, Iowa,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-6916","authenticated-orcid":false,"given":"April","family":"Blong","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University Department of Veterinary Clinical Sciences, , Ames, Iowa,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Kishbaugh","sequence":"additional","affiliation":[{"name":"BodeVet , Rockville, Maryland,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne S.","family":"Hale","sequence":"additional","affiliation":[{"name":"BodeVet , Rockville, Maryland,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2026020922124454800_jvim15922-bib-0001","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1939-165X.1991.tb00566.x","article-title":"Epidemiologic survey of thrombocytopenia in dogs: a report on 987 cases","volume":"20","author":"Grindem","year":"1991","journal-title":"Vet Clin Pathol"},{"key":"2026020922124454800_jvim15922-bib-0002","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/vr.164.21.647","article-title":"Retrospective study of 871 dogs with thrombocytopenia","volume":"164","author":"Botsch","year":"2009","journal-title":"Vet Rec"},{"key":"2026020922124454800_jvim15922-bib-0003","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1476-4431.2009.00454.x","article-title":"Canine platelet transfusions","volume":"19","author":"Callan","year":"2009","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0004","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2460\/javma.235.8.960","article-title":"Underlying diseases and clinicopathologic variables of thrombocytopenic dogs with and without platelet-bound antibodies detected by use of a flow cytometric assay: 83 cases (2004-2006)","volume":"235","author":"Dircks","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922124454800_jvim15922-bib-0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/vec.12777","article-title":"Retrospective evaluation of 4 methods for outcome prediction in overt disseminated intravascular coagulation in dogs (2009-2014): 804 cases","volume":"28","author":"Goggs","year":"2018","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0006","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.2460\/javma.231.10.1540","article-title":"Diagnostic use of cytologic examination of bone marrow from dogs with thrombocytopenia: 58 cases (1994-2004)","volume":"231","author":"Miller","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922124454800_jvim15922-bib-0007","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ajh.21060","article-title":"Treatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: a retrospective review of 40 patients","volume":"83","author":"Spahr","year":"2008","journal-title":"Am J Hematol"},{"key":"2026020922124454800_jvim15922-bib-0008","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","article-title":"International consensus report on the investigation and management of primary immune thrombocytopenia","volume":"115","author":"Provan","year":"2010","journal-title":"Blood"},{"key":"2026020922124454800_jvim15922-bib-0009","first-page":"503","article-title":"Early haemorrhage control and management of trauma-induced coagulopathy: the importance of goal-directed therapy","volume":"23","author":"Stensballe","year":"2017","journal-title":"Curr Opin Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0010","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/TA.0000000000001333","article-title":"Damage control resuscitation in patients with severe traumatic hemorrhage: a practice management guideline from the eastern association for the surgery of trauma","volume":"82","author":"Cannon","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"key":"2026020922124454800_jvim15922-bib-0011","first-page":"S77","article-title":"An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients","volume":"66","author":"Perkins","year":"2009","journal-title":"J Trauma"},{"key":"2026020922124454800_jvim15922-bib-0012","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1537-2995.2009.02414.x","article-title":"Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients","volume":"50","author":"Shaz","year":"2010","journal-title":"Transfusion"},{"key":"2026020922124454800_jvim15922-bib-0013","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1182\/bloodadvances.2018017699","article-title":"Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized proppr trial","volume":"2","author":"Cardenas","year":"2018","journal-title":"Blood Adv"},{"key":"2026020922124454800_jvim15922-bib-0014","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/bjh.14423","article-title":"Guidelines for the use of platelet transfusions","volume":"176","author":"Estcourt","year":"2017","journal-title":"Br J Haematol"},{"key":"2026020922124454800_jvim15922-bib-0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13054-016-1265-x","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition","volume":"20","author":"Rossaint","year":"2016","journal-title":"Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0016","first-page":"S59","article-title":"Lyophilized platelets: challenges and opportunities","volume":"70","author":"Cap","year":"2011","journal-title":"J Trauma"},{"key":"2026020922124454800_jvim15922-bib-0017","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/10731190600974962","article-title":"Lyophilized platelets: fifty years in the making","volume":"35","author":"Bode","year":"2007","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"key":"2026020922124454800_jvim15922-bib-0018","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1111\/trf.14972","article-title":"Safety evaluation of a lyophilized platelet-derived hemostatic product","volume":"58","author":"Barroso","year":"2018","journal-title":"Transfusion"},{"key":"2026020922124454800_jvim15922-bib-0019","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0195-5616(03)00095-0","article-title":"Triggers for prophylactic use of platelet transfusions and optimal platelet dosing in thrombocytopenic dogs and cats","volume":"33","author":"Abrams-Ogg","year":"2003","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020922124454800_jvim15922-bib-0020","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1476-4431.2011.00706.x","article-title":"Platelet transfusions: treatment options for hemorrhage secondary to thrombocytopenia","volume":"22","author":"Hux","year":"2012","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0021","first-page":"55","article-title":"Manual of Veterinary Transfusion Medicine and Blood Banking","author":"Callan","year":"2016","edition":"1"},{"key":"2026020922124454800_jvim15922-bib-0022","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.2460\/ajvr.69.12.1580","article-title":"Assessment of a dimethyl sulfoxide-stabilized frozen canine platelet concentrate","volume":"69","author":"Guillaumin","year":"2008","journal-title":"Am J Vet Res"},{"key":"2026020922124454800_jvim15922-bib-0023","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1476-4431.2010.00580.x","article-title":"Analysis of a commercial dimethyl-sulfoxide-stabilized frozen canine platelet concentrate by turbidimetric aggregometry","volume":"20","author":"Guillaumin","year":"2010","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0024","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1939-1676.2008.0225.x","article-title":"Cryopreservation of canine platelets","volume":"23","author":"Appleman","year":"2009","journal-title":"J Vet Intern Med"},{"key":"2026020922124454800_jvim15922-bib-0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0011-2240(86)90023-4","article-title":"Cryopreservation of dog platelets with dimethyl sulfoxide: therapeutic effectiveness of cryopreserved platelets in the treatment of thrombocytopenic dogs, and the effect of platelet storage at \u221280 degrees c","volume":"23","author":"Valeri","year":"1986","journal-title":"Cryobiology"},{"key":"2026020922124454800_jvim15922-bib-0026","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/vec.12503","article-title":"Cryopreserved platelet concentrate transfusions in 43 dogs: a retrospective study (2007-2013)","volume":"26","author":"Ng","year":"2016","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0027","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1476-4431.2011.00710.x","article-title":"Use of fresh platelet concentrate or lyophilized platelets in thrombocytopenic dogs with clinical signs of hemorrhage: a preliminary trial in 37 dogs","volume":"22","author":"Davidow","year":"2012","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0028","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/jvim.15089","article-title":"Development and implementation of a novel immune thrombocytopenia bleeding score for dogs","volume":"32","author":"Makielski","year":"2018","journal-title":"J Vet Intern Med"},{"key":"2026020922124454800_jvim15922-bib-0029","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jvim.13823","article-title":"Update on canine and feline blood donor screening for blood-borne pathogens","volume":"30","author":"Wardrop","year":"2016","journal-title":"J Vet Intern Med"},{"key":"2026020922124454800_jvim15922-bib-0030","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/j.1537-2995.2005.00647.x","article-title":"Freezing human platelets with 6 percent dimethyl sulfoxide with removal of the supernatant solution before freezing and storage at \u221280 degrees c without postthaw processing","volume":"45","author":"Valeri","year":"2005","journal-title":"Transfusion"},{"key":"2026020922124454800_jvim15922-bib-0031","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tvjl.2011.03.015","article-title":"Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography","volume":"191","author":"Goggs","year":"2012","journal-title":"Vet J"},{"key":"2026020922124454800_jvim15922-bib-0032","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1939-165X.2005.tb00066.x","article-title":"Validation of human recombinant tissue factor-activated thromboelastography on citrated whole blood from clinically healthy dogs","volume":"34","author":"Wiinberg","year":"2005","journal-title":"Vet Clin Pathol"},{"key":"2026020922124454800_jvim15922-bib-0033","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/vec.12147","article-title":"Systematic evaluation of evidence on veterinary viscoelastic testing part 3: assay activation and test protocol","volume":"24","author":"deLaforcade","year":"2014","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/vec.12144","article-title":"Partnership on rotational viscoelastic test standardization (PROVETS): evidence-based guidelines on rotational viscoelastic assays in veterinary medicine","volume":"24","author":"Goggs","year":"2014","journal-title":"J Vet Emerg Crit Care"},{"key":"2026020922124454800_jvim15922-bib-0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1939-165X.2011.00282.x","article-title":"Monitoring unfractionated heparin therapy in dogs by measuring thrombin generation","volume":"40","author":"Allegret","year":"2011","journal-title":"Vet Clin Pathol"},{"key":"2026020922124454800_jvim15922-bib-0036","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/trf.12943","article-title":"Platelet transfusion: a systematic review of the clinical evidence","volume":"55","author":"Kumar","year":"2015","journal-title":"Transfusion"},{"key":"2026020922124454800_jvim15922-bib-0037","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tracli.2018.06.004","article-title":"Platelet transfusion: current challenges","volume":"25","author":"Humbrecht","year":"2018","journal-title":"Transfus Clin Biol"},{"key":"2026020922124454800_jvim15922-bib-0038","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/jsap.12621","article-title":"Treatment of presumptive primary immune-mediated thrombocytopenia with mycophenolate mofetil versus cyclosporine in dogs","volume":"58","author":"Cummings","year":"2017","journal-title":"J Small Anim Pract"},{"key":"2026020922124454800_jvim15922-bib-0039","first-page":"514","article-title":"Outcome based on treatment protocol in patients with primary canine immune-mediated thrombocytopenia: 46 cases (2000-2013)","volume":"57","author":"Scuderi","year":"2016","journal-title":"Can Vet J"},{"key":"2026020922124454800_jvim15922-bib-0040","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jsap.12203","article-title":"Treatment of five haemodynamically stable dogs with immune-mediated thrombocytopenia using mycophenolate mofetil as single agent","volume":"55","author":"Yau","year":"2014","journal-title":"J Small Anim Pract"},{"key":"2026020922124454800_jvim15922-bib-0041","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2460\/javma.238.3.346","article-title":"Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia","volume":"238","author":"O'Marra","year":"2011","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922124454800_jvim15922-bib-0042","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jvim.12066","article-title":"A prospective randomized clinical trial of vincristine versus human intravenous immunoglobulin for acute adjunctive management of presumptive primary immune-mediated thrombocytopenia in dogs","volume":"27","author":"Balog","year":"2013","journal-title":"J Vet Intern Med"},{"key":"2026020922124454800_jvim15922-bib-0043","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2460\/javma.2002.220.477","article-title":"Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs","volume":"220","author":"Rozanski","year":"2002","journal-title":"J Am Vet Med Assoc"},{"key":"2026020922124454800_jvim15922-bib-0044","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2141.2007.06635.x","article-title":"The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP","volume":"138","author":"Page","year":"2007","journal-title":"Br J Haematol"},{"key":"2026020922124454800_jvim15922-bib-0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1423-0410.2005.00592.x","article-title":"Survival of baboon biotin-x-n-hydroxysuccinimide and (111)in-oxine-labelled autologous fresh and lyophilized reconstituted platelets","volume":"88","author":"Valeri","year":"2005","journal-title":"Vox Sang"},{"key":"2026020922124454800_jvim15922-bib-0046","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1182\/blood-2017-08-743229","article-title":"Mechanisms of platelet clearance and translation to improve platelet storage","volume":"131","author":"Quach","year":"2018","journal-title":"Blood"},{"key":"2026020922124454800_jvim15922-bib-0047","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1073\/pnas.92.2.397","article-title":"Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion","volume":"92","author":"Read","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026020922124454800_jvim15922-bib-0048","first-page":"2483","article-title":"Stableplate rx canine promotes in vitro thrombin generation and thrombus formation under high shear","volume":"33","author":"Ishler","year":"2019","journal-title":"J Vet Intern Med"},{"key":"2026020922124454800_jvim15922-bib-0049","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7754\/Clin.Lab.2016.160910","article-title":"Evaluation of the lyophilized platelets function by thromboelastography in an in vitro platelet transfusion model","volume":"63","author":"Deng","year":"2017","journal-title":"Clin Lab"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvim.15922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvim.15922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/34\/6\/2384\/66661624\/jvim15922.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/34\/6\/2384\/66661624\/jvim15922.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:24:03Z","timestamp":1770693843000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/34\/6\/2384\/8448442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.15922","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,11,1]]},"assertion":[{"value":"2020-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}