{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:21:05Z","timestamp":1784323265703,"version":"3.55.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Royal Canin SAS"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cats with subclinical hypertrophic cardiomyopathy (sHCM) have elevated serum insulin and serum amyloid A concentrations correlating with the degree of cardiac hypertrophy. Diet might affect these and other cardiac variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate the effect of a complete, balanced diet with restricted starch and supplemented with eicosapentaenoic acid\u2009+\u2009docosahexaenoic acid (EPA\u2009+\u2009DHA) on echocardiographic variables and cardiac biomarkers in cats with sHCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-four client-owned cats with sHCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, randomized, double-blind, multicenter study enrolled cats with end-diastole interventricular septum thickness (IVSd) or left ventricular wall thickness (LVWd) \u22656\u2009mm, or both. Nonsedated, fasted cats were examined at baseline and after 6 and 12\u2009months of Test (restricted starch and EPA\u2009+\u2009DHA supplements) (n = 23) or Control (unrestricted starch without EPA\u2009+\u2009DHA supplementation) (n = 21) diet. Assessments included auscultation, body weight, body condition score, echocardiography and blood analysis. Linear and generalized mixed models analyzed diet, time and diet * time interactions (5% significance level).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No differences between diet groups were significant for any variable at any timepoint. There were significant decreases in the Test but not Control group in maximum IVSd (P = .03), maximum LVWd (P = .02) and insulin-like growth factor-1 levels (P = .04) after 12\u2009months, and in ultrasensitive cardiac troponin I (cTnI) (P = .001) after 6 months; effect sizes (95% confidence interval) were 0.53 (0.09; 0.99), 0.63 (0.18; 1.09), 0.61 (0.16; 1.07), and 0.37 (\u22120.06; 0.8), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Cats with sHCM fed Test diet had significant decreases in echocardiographic variables of sHCM and in cTnI and IGF-1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15925","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T07:03:56Z","timestamp":1603955036000},"page":"2197-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of diet with left ventricular wall thickness, troponin I and IGF-1 in cats with subclinical hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-9906","authenticated-orcid":false,"given":"Ingrid","family":"van Hoek","sequence":"first","affiliation":[{"name":"Royal Canin SAS , Aimargues,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Hodgkiss-Geere","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Science, Leahurst, University of Liverpool Department of Small Animal Clinical Science, , Neston,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth F.","family":"Bode","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Science, Leahurst, University of Liverpool Department of Small Animal Clinical Science, , Neston,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hamilton-Elliott","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Science, Leahurst, University of Liverpool Department of Small Animal Clinical Science, , Neston,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"M\u00f5tsk\u00fcla","sequence":"additional","affiliation":[{"name":"Estonian University of Life Sciences , Tartu,","place":["Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Palermo","sequence":"additional","affiliation":[{"name":"Anderson Moores Veterinary Specialists , Hampshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Martinez","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Edinburgh , Midlothian,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff J.","family":"Culshaw","sequence":"additional","affiliation":[{"name":"University of Edinburgh , Midlothian,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Laxalde","sequence":"additional","affiliation":[{"name":"Royal Canin SAS , Aimargues,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Dukes-McEwan","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Science, Leahurst, University of Liverpool Department of Small Animal Clinical Science, , Neston,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2026020922130045900_jvim15925-bib-0001","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2460\/javma.234.11.1398","article-title":"Prevalence of cardiomyopathy in apparently healthy cats","volume":"234","author":"Paige","year":"2009","journal-title":"J Am Vet Med Assoc"},{"issue":"6","key":"2026020922130045900_jvim15925-bib-0002","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1016\/j.jvc.2015.03.008","article-title":"Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)","volume":"17","author":"Payne","year":"2015","journal-title":"J Vet Cardiol"},{"key":"2026020922130045900_jvim15925-bib-0003","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jfms.2011.05.006","article-title":"Is treatment of feline hypertrophic cardiomyopathy based in science or faith? 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