{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:38Z","timestamp":1770745058088,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1920,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is unclear whether a low total 25(OH)D concentration is a cause or consequence of illnesses. To address this knowledge gap, studies measuring free and total 25(OH)D during the evolution and resolution of an inflammatory process are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Serum total and free 25(OH)D concentrations would transiently decline after cruciate surgery in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seventeen client-owned dogs with a spontaneous cranial cruciate ligament rupture (CCLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal cohort study involving the measurement of serum concentrations of total and free 25(OH)D, total calcium, creatinine, albumin, phosphate, C-reactive protein and plasma ionized calcium, at 1\u2009day before and a median time of 1 and 60\u2009days after surgical treatment of CCLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median serum concentrations of total 25(OH)D before surgery (80.3\u2009nmoL\/L [range, 43.5-137.3]) significantly declined immediately after surgery; (64.8\u2009nmoL\/L [range, 36.3-116.5] 1\u2009day after surgery, P &amp;lt;\u2009.005) before increasing to become nonsignificantly different from concentrations before surgery at day 60 after surgery (median 78.0\u2009nmoL\/L [range, 24.2-115.8], P =\u2009.14). In contrast, median free 25(OH)D concentrations before surgery (7.6\u2009pg\/mL [range, 3.8-12.2]) significantly increased immediately after surgery (9.2\u2009pg\/mL [range, 5.2-15.7], P &amp;lt;\u2009.05) before declining to become nonsignificantly different from before surgery concentrations at day 60 after surgery (median 6.2\u2009pg\/mL [range, 4.0-15.8], P =\u2009.37).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>This study reveals the difficulties of assessing vitamin D status in dogs following elective surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.15933","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T07:55:01Z","timestamp":1602662101000},"page":"2617-2621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs"],"prefix":"10.1093","volume":"34","author":[{"given":"Dylan N.","family":"Clements","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Bruce","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian G.","family":"Handel","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-9891","authenticated-orcid":false,"given":"Ioannis L.","family":"Oikonomidis","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam G.","family":"Gow","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Evans","sequence":"additional","affiliation":[{"name":"Nationwide Specialist Laboratories, Unit 2 Sawston Park , Cambridge, Cambridgeshire,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Campbell","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Hurst","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-7007","authenticated-orcid":false,"given":"Richard J.","family":"Mellanby","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals , Roslin, Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2026020922121402400_jvim15933-bib-0001","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D 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